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公开(公告)号：US11999954B2
公开(公告)日：2024-06-04
申请号：US17172461
申请日：2021-02-10
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N2310/141
摘要： Disclosed herein are programmable, conditionally activated small interfering RNA constructs (Cond-siRNAs) and methods of making and using the same as therapeutic agents. The Cond-siRNA comprises a sensor strand, a core strand, and a guide strand, which crossover to form a sensor duplex and a RNAi duplex attached to each other to form a single structure. Upon binding an input strand to the sensor strand, the Cond-siRNA is activated and releases RNAi targeting a desired gene.
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2.发明授权Exonuclease resistant polynucleotide and related duplex polynucleotides, constructs, compositions, methods and systems 有权外切核酸酶多核苷酸和相关的双链多核苷酸，构建体，组合物，方法和系统公开(公告)号：US09115355B2
公开(公告)日：2015-08-25
申请号：US14093387
申请日：2013-11-29
IPC分类号： C12N15/113 , C12N15/11
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/14 , C12N2310/3519 , C12N2320/32 , C12N2320/51
摘要： Provided herein are exonuclease resistant polynucleotides and related constructs, compositions, methods and systems.
摘要翻译： 本文提供了外切核酸酶抗性多核苷酸和相关构建体，组合物，方法和系统。
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3.发明授权Using a field effect device for identifying translocating charge-tagged molecules in a nanopore sequencing device 有权使用场效应装置来识别纳米孔测序装置中的易位电荷标记分子公开(公告)号：US09090936B2
公开(公告)日：2015-07-28
申请号：US13621745
申请日：2012-09-17
IPC分类号： B82Y15/00 , C12Q1/68 , G01N27/447 , G01N33/18
CPC分类号： G01N33/48721 , B82Y15/00 , C12Q1/6869 , G01N27/4145 , G01N27/44704 , G01N33/18 , G01N33/1826 , H01L51/0048 , H01L51/055 , H01L51/0558
摘要： A detector apparatus includes a field-effect transistor configured to undergo a change in amplitude of a source-to-drain current when at least a portion of a charge-tagged molecule translocates through the nanopore. In some implementations, the field-effect transistor is a carbon nanotube field effect transistor and the nanopore is located in a membrane. In other implementations, the field-effect transistor is a carbon nanotube field effect transistor and the nanopore is implemented in the form of a nano-channel in a semiconductor layer.
摘要翻译： 检测器装置包括场效应晶体管，配置为当电荷标记分子的至少一部分通过纳米孔转位时，经历源极 - 漏极电流的振幅变化。 在一些实施方案中，场效应晶体管是碳纳米管场效应晶体管，并且纳米孔位于膜中。 在其他实施方案中，场效应晶体管是碳纳米管场效应晶体管，并且纳米孔以半导体层中的纳米通道的形式实现。
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公开(公告)号：US10330678B2
公开(公告)日：2019-06-25
申请号：US15009824
申请日：2016-01-29
IPC分类号： G01N33/566 , A61K31/17 , A61K31/10 , A61K31/12 , A61K31/122 , A61K31/167 , A61K31/205 , A61K31/352 , A61K31/353 , A61K31/365 , A61K31/4375 , A61K31/4745 , A61K31/513 , A61K31/7016 , A61K31/704 , A61K47/61
摘要： Provided herein are bitter taste receptor ligands, related agents, combinations, compositions, methods and systems for modulating release of a metabolic hormone in vitro and in vivo from cells of the GI tract of an individual.
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公开(公告)号：US09488636B2
公开(公告)日：2016-11-08
申请号：US14746757
申请日：2015-06-22
IPC分类号： B82Y15/00 , G01N33/487 , H01L51/05 , H01L51/00 , G01N27/414 , C12Q1/68 , G01N27/447 , G01N33/18
CPC分类号： G01N33/48721 , B82Y15/00 , C12Q1/6869 , G01N27/4145 , G01N27/44704 , G01N33/18 , G01N33/1826 , H01L51/0048 , H01L51/055 , H01L51/0558
摘要： A detector apparatus includes a field-effect transistor configured to undergo a change in amplitude of a source-to-drain current when at least a portion of a charge-tagged molecule translocates through the nanopore. In some implementations, the field-effect transistor is a carbon nanotube field effect transistor and the nanopore is located in a membrane. In other implementations, the field-effect transistor is a carbon nanotube field effect transistor and the nanopore is implemented in the form of a nano-channel in a semiconductor layer.
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公开(公告)号：US09234882B2
公开(公告)日：2016-01-12
申请号：US14576148
申请日：2014-12-18
IPC分类号： G01N33/48 , G01N33/487 , H01L51/05 , H01L51/00 , G01N27/414 , B82Y15/00 , C12Q1/68 , G01N27/447 , G01N33/18
CPC分类号： G01N33/48721 , B82Y15/00 , C12Q1/6869 , G01N27/4145 , G01N27/44704 , G01N33/18 , G01N33/1826 , H01L51/0048 , H01L51/055 , H01L51/0558
摘要： By driving molecules electrophoretically through a nanopore, single molecule detection can be achieved. To enhance translocational control, functionalized and non-functionalized electrodes are strategically placed around or above a nanopore. Changes in transmission spectra and input voltage detected by electrodes allow accurate identification of single molecules as they pass through a nanopore.
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7.发明申请公开(公告)号：US20200072832A1
公开(公告)日：2020-03-05
申请号：US16450342
申请日：2019-06-24
IPC分类号： G01N33/566 , A61K31/12 , A61K31/122 , A61K31/167 , A61K31/205 , A61K31/352 , A61K31/353 , A61K31/365 , A61K31/4375 , A61K31/4745 , A61K31/513 , A61K31/7016 , A61K47/61 , A61K31/10 , A61K31/17 , A61K31/704
摘要： Provided herein are bitter taste receptor ligands, related agents, combinations, compositions, methods and systems for modulating release of a metabolic hormone in vitro or in vivo from cells of the GI tract of an individual.
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8.发明申请Methods for providing bond activation catalysts and related catalysts, systems, and methods 有权提供键活化催化剂和相关催化剂，体系和方法的方法公开(公告)号：US20140243545A1
公开(公告)日：2014-08-28
申请号：US14192856
申请日：2014-02-27
发明人： William A. Goddard, III , Mu-Jeng Cheng , Ross Fu
IPC分类号： B01J27/198 , B01J27/19 , C07C253/26
CPC分类号： B01J27/198 , B01J23/002 , B01J23/6482 , B01J23/6525 , B01J27/02 , B01J27/0576 , B01J27/19 , B01J2523/00 , C07C253/24 , Y02P20/52 , C07C255/08 , B01J2523/51 , B01J2523/55 , B01J2523/56 , B01J2523/64 , B01J2523/68
摘要： Described herein are catalysts for activation of an R—H bond in a R—H substrate and related catalytic matrices, compositions, methods and systems.
摘要翻译： 本文描述了用于活化R-H底物中的R-H键和相关催化基质，组合物，方法和体系的催化剂。
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9.发明授权公开(公告)号：US10532330B2
公开(公告)日：2020-01-14
申请号：US15497174
申请日：2017-04-25
摘要： Filtration membrane comprising polymeric nanofibers and/or microfibers attaching dendrimer component presenting reactive sites selective for chemicals to be filtered, and related nanofibers and microfibers, composite materials, compositions, methods and system.
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公开(公告)号：US09725715B2
公开(公告)日：2017-08-08
申请号：US14641261
申请日：2015-03-06
IPC分类号： C12N15/113 , C12N15/11
CPC分类号： C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/531 , C12N2320/10 , C12N2320/32 , C12N2320/50
摘要： Provided herein are signal activatable molecular constructs for delivery of molecules and related components, compositions, methods, and systems, having a 17 to 30 bp targeting domain duplex RNA, at least one protection strand having a protection segment and linker segment and a sensor strand having a displacement segment and a toehold segment, in which in an inactive conformation the protection segment and the displacement segment form a sensor domain duplex polynucleotide covalently attached to the targeting domain and presenting the toehold segment for binding to a signal molecule. In an active conformation the sensor strand is bound to the signal molecule and is detached from the at least one protection strand and from the targeting domain; and the targeting domain attaches the at least one protection strand in a configuration allowing processing by Dicer and/or an Argonaute enzyme.
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