公开(公告)号：US20210332011A1

公开(公告)日：2021-10-28

申请号：US17055970

申请日：2019-05-14

Applicant: California Institute of Technology

Inventor： Jiaming LI ,  Xu CHEN ,  Tonia S. AHMED ,  Brian STOLTZ ,  Robert H. GRUBBS

IPC: C07C405/00 ,  B01J23/46

Abstract: This invention relates generally to the synthesis of Δ12-Prostaglandin J product using stereoretentive ruthenium olefin metathesis catalysts supported by dithiolate ligands. Δ12-Prostaglandin J products were generated with excellent selectivity (>99% Z) and in moderate to high/good yields (47% to 80% yield; 58% to 80% yield).

公开(公告)号：US20210355099A1

公开(公告)日：2021-11-18

申请号：US17336756

申请日：2021-06-02

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Tonia S. AHMED ,  Robert H. GRUBBS

IPC: C07D313/00 ,  B01J31/22

Abstract: A highly efficient, Z-selective ring-closing metathesis system for the formation of macrocycles using a stereoretentive, ruthenium-based catalyst supported by a dithiolate ligand is reported. This catalyst is demonstrated to be remarkably active as observed in initiation experiments showing complete catalyst initiation at −20° C. within 10 min. Using easily accessible diene starting materials bearing a Z-olefin moiety, macrocyclization reactions generated products with significantly higher Z-selectivity in appreciably shorter reaction times, in higher yield, and with much lower catalyst loadings than in previously reported systems. Macrocyclic lactones ranging in size from twelve-membered to seventeen-membered rings are synthesized in moderate to high yields (68-79% yield) with excellent Z-selectivity (95%-99% Z).

公开(公告)号：US20170022231A1

公开(公告)日：2017-01-26

申请号：US15074545

申请日：2016-03-18

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Choon Woo LEE ,  Robert H. GRUBBS ,  Pablo E. GUZMAN ,  Tonia S. AHMED ,  T. Patrick MONTGOMERY

IPC: C07F15/00 ,  B01J31/12 ,  C07C67/475 ,  C08F12/08 ,  C07C67/30 ,  C07D313/00

CPC classification number: C07F15/0046 ,  B01J31/122 ,  B01J31/28 ,  B01J2231/543 ,  B01J2531/821 ,  C07B2200/09 ,  C07C67/293 ,  C07C67/30 ,  C07C67/333 ,  C07C67/475 ,  C07C2601/10 ,  C07D313/00 ,  C08F2500/25 ,  C08G61/08 ,  C08G2261/3322 ,  C08G2261/418 ,  C07C69/74 ,  C07C69/16 ,  C07C69/78 ,  C07C69/76

Abstract: This invention relates generally to olefin metathesis catalyst compounds, to the preparation of such compounds, and the use of such catalysts in the metathesis of olefins and olefin compounds, more particularly, in the use of such catalysts in (E)-selective olefin metathesis reactions. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and industrial and fine chemicals chemistry.

Abstract translation: 本发明一般涉及烯烃复分解催化剂化合物，这些化合物的制备，以及这些催化剂在烯烃和烯烃化合物的复分解中的用途，更具体地说，在（E）选择性烯烃复分解反应中使用这种催化剂 。 本发明在催化，有机合成，聚合物化学，工业和精细化学品化学领域具有实用价值。

公开(公告)号：US20210053043A1

公开(公告)日：2021-02-25

申请号：US17094004

申请日：2020-11-10

Applicant: Umicore AG & Co. KG ,  California Institute of Technology

Inventor： Adam M. JOHNS ,  T. Patrick MONTGOMERY ,  Tonia S. AHMED ,  Robert H. GRUBBS ,  Richard L. PEDERSON

IPC: B01J31/22 ,  C07C6/06 ,  C07C6/04

Abstract: This invention relates generally to metathesis catalysts and the use of such catalysts in the metathesis of olefins and olefin compounds, more particularly, in the use of such catalysts in Z and E selective olefin metathesis reactions. The invention has utility in the fields of organometallics and organic synthesis.

公开(公告)号：US20180361371A1

公开(公告)日：2018-12-20

申请号：US16060466

申请日：2016-12-09

Applicant: Umicore AG & Co. KG ,  California Institute of Technology

Inventor： Adam M. JOHNS ,  T. Patric MONTGOMERY ,  Tonia S. AHMED ,  Robert H. GRUBBS ,  Richard L. PEDERSON

IPC: B01J31/22 ,  C07C6/04

Abstract: This invention relates generally to metathesis catalysts and the use of such catalysts in the metathesis of olefins and olefin compounds, more particularly, in the use of such catalysts in Z and E selective olefin metathesis reactions. The invention has utility in the fields of organometallics and organic synthesis.