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公开(公告)号：US20230355242A1
公开(公告)日：2023-11-09
申请号：US18096256
申请日：2023-01-12
发明人： Max KUDISCH , Jeong Hoon KO , Chiara DARAIO , Mikhail G. SHAPIRO , Di WU , Gunho KIM , Robert H. GRUBBS , Michael R. HARRISON , Sunghoon KIM
IPC分类号： A61B17/12
CPC分类号： A61B17/12136 , A61B17/1204 , A61B17/12031
摘要： Aspects disclosed herein include an implantable, detachable, and removable medical device comprising: a therapeutic balloon configured to perform a therapeutic activity inside a living subject; and a focused-ultrasound activatable actuator operably connected to the therapeutic balloon; wherein the actuator is capable of being activated between a closed state and an open state remotely via a focused ultrasound beam; wherein the device is configured to be in an implantation state to facilitate implantation of the device in the living subject, in a therapeutic state to facilitate performance of the therapeutic activity, and subsequently in an expulsion state to facilitate expulsion of the medical device from the living subject; and wherein the implantation state, therapeutic state, and expulsion state are different from each other
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2.发明公开公开(公告)号：US20230173071A1
公开(公告)日：2023-06-08
申请号：US18082812
申请日：2022-12-16
申请人： California Institute of Technology , The Regents Of the University of California , U.S. Government represented by the Development of Veterans Affairs
发明人： John B. JARMAN , Dennis A. DOUGHERTY , Robert H. GRUBBS , Christopher B. MAROTTA , Daniel M. SCHWARTZ
CPC分类号： A61K41/0057 , A61P27/02
摘要： This current disclosure is directed to compositions based on certain heptamethine dyes useful for generating singlet oxygen using NIR radiation, optionally comprising additives and solvents that enhance the performance of these dyes, and procedures using these compositions to modify treat myopia and other ocular conditions. In some cases, the methods use near-infrared irradiation to improve the mechanical strength of the sclera.
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公开(公告)号：US20160289392A1
公开(公告)日：2016-10-06
申请号：US15065291
申请日：2016-03-09
IPC分类号： C08G81/00
CPC分类号： H01M10/0565 , C08G61/02 , C08G61/08 , C08G81/00 , C08G2261/126 , C08G2261/1426 , C08G2261/143 , C08G2261/148 , C08G2261/149 , C08G2261/3324 , C08G2261/3325 , C08G2261/418 , C08G2261/516 , C08G2261/792 , C08L65/00 , C08L87/005 , H01M10/0525 , H01M14/005 , H01M2008/1095 , H01M2300/0082
摘要： Provided herein is a class of copolymers, including triblock brush copolymers having specific block configurations, for example, ABC triblock brush copolymers and ABA triblock brush copolymers. In an embodiment, for example, copolymers of the invention incorporate various polymer side chain groups which contribute beneficial physical, chemical, or electronic properties such as increased mechanical or elastic strength, improved ionic or electric conductivity. In some embodiments, the provided copolymers exhibit advantageous steric properties allowing for rapid self-assembly into a variety of morphologies that are substantially different than non-brush, block copolymers.
摘要翻译： 本文提供了一类共聚物，包括具有特定嵌段构型的三嵌段共聚物，例如ABC三嵌段共聚物和ABA三嵌段共聚物。 在一个实施方案中，例如，本发明的共聚物包含各种有助于物理，化学或电子性质的聚合物侧链基团，例如增加的机械或弹性强度，改进的离子或导电性。 在一些实施方案中，所提供的共聚物表现出有利的空间特性，允许快速自组装成与非刷嵌段共聚物基本上不同的各种形态。
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公开(公告)号：US20160185684A1
公开(公告)日：2016-06-30
申请号：US14789848
申请日：2015-07-01
IPC分类号： C07B37/02 , C07F15/00 , C07C67/293 , C07D207/46 , C07C6/04 , C07D211/94 , C07D471/04 , C07D317/12 , C07C29/44 , C07C67/347 , B01J31/22 , C07F7/18
CPC分类号： C07B37/02 , B01J31/2208 , B01J31/2278 , B01J2231/54 , B01J2231/543 , B01J2531/821 , C07B2200/09 , C07C6/04 , C07C29/32 , C07C67/293 , C07C67/343 , C07C67/475 , C07C2531/22 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D207/46 , C07D211/94 , C07D317/12 , C07D471/04 , C07F7/1892 , C07F15/0046 , C07C69/145 , C07C69/63 , C07C69/78 , C07C33/025 , C07C69/593 , C07C69/608 , C07C15/50
摘要： This invention relates generally to C—H activated ruthenium olefin metathesis catalyst compounds which are stereogenic at the ruthenium center, to their preparation, and the use of such catalysts in the metathesis of olefins and olefin compounds. In particular, the invention relates to the use of C—H activated ruthenium olefin metathesis catalyst compounds in Z-selective olefin metathesis reactions, enantio-selective olefin metathesis reactions, and enantio-Z-selective olefin metathesis reactions. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and industrial and fine chemicals chemistry.
摘要翻译： 本发明一般涉及在钌中心立体定向的C-H活化的钌烯烃复分解催化剂化合物及其制备方法，以及这些催化剂在烯烃和烯烃化合物的复分解中的用途。 特别地，本发明涉及C-H活化的钌烯烃复分解催化剂化合物在Z选择性烯烃复分解反应，对映选择性烯烃复分解反应和对映体Z选择性烯烃复分解反应中的用途。 本发明在催化，有机合成，聚合物化学，工业和精细化学品化学领域具有实用价值。
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5.发明申请LATENT, HIGH-ACTIVITY OLEFIN METATHESIS CATALYSTS CONTAINING AN N-HETEROCYCLIC CARBENE LIGAND 有权专利，高活性烯烃催化剂含有N-杂环碳酸盐配体公开(公告)号：US20150141603A1
公开(公告)日：2015-05-21
申请号：US14497387
申请日：2014-09-26
发明人： Thay UNG , Yann SCHRODI , Mark S. TRIMMER , Andrew HEJL , Daniel SANDERS , Robert H. GRUBBS
IPC分类号： C08G61/02 , C07D493/10
CPC分类号： C08G61/02 , C07C67/333 , C07D493/10 , C07F15/0046 , C08F132/08 , C08G61/06 , C08G2261/11 , C08G2261/3325 , C08G2261/418
摘要： The invention provides novel organometallic complexes useful as olefin metathesis catalysts. The complexes have an N-heterocyclic carbene ligand and a chelating carbene ligand associated with a Group 8 transition metal center. The molecular structure of the complexes can be altered so as to provide a substantial latency period. The complexes are particularly useful in catalyzing ring closing metathesis of acyclic olefins and ring opening metathesis polymerization of cyclic olefins.
摘要翻译： 本发明提供了用作烯烃复分解催化剂的新型有机金属络合物。 络合物具有与8族过渡金属中心相关的N-杂环卡宾配体和螯合卡宾配体。 可以改变配合物的分子结构，以便提供大量潜伏期。 该络合物特别可用于催化环烯烃的闭环复分解和环烯烃的开环易位聚合。
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6.发明申请PHOTONIC STRUCTURES FROM SELF ASSEMBLY OF BRUSH BLOCK COPOLYMERS AND POLYMER BLENDS 有权BRUSH嵌段共聚物和聚合物共混自组装的光电结构公开(公告)号：US20140011958A1
公开(公告)日：2014-01-09
申请号：US13930400
申请日：2013-06-28
IPC分类号： G02B1/00
CPC分类号： G02B1/005 , C08F222/04 , C08F222/40 , C08F293/00 , C08F299/00 , C08G81/00 , C08L87/005 , G02F1/0054 , G02F2202/32
摘要： The invention provides a class of block copolymers having a plurality of chemically different blocks, at least a portion of which incorporating polymer side chain groups having a helical secondary structure. The invention also provides structures generated by self-assembly of polymer blends including at least one block copolymer component, such as a brush block polymer or wedge-type block polymer. The invention provides, for example, periodic nanostructures and microstructures generated by self-assembly of block copolymers and polymer blends comprising a mixture of at least one block copolymer component, such as a brush block copolymer, and at least a second component.
摘要翻译： 本发明提供了一类具有多个化学上不同的嵌段的嵌段共聚物，其至少一部分结合了具有螺旋二级结构的聚合物侧链基团。 本发明还提供通过包括至少一种嵌段共聚物组分如刷嵌聚合物或楔形嵌段聚合物的聚合物共混物的自组装产生的结构。 本发明提供了例如通过嵌段共聚物和包含至少一种嵌段共聚物组分如刷嵌段共聚物和至少第二组分的混合物的聚合物共混物自组装产生的周期性纳米结构和微结构。
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公开(公告)号：US20230219282A1
公开(公告)日：2023-07-13
申请号：US18096251
申请日：2023-01-12
发明人： Max KUDISCH , Jeong Hoon KO , Chiara DARAIO , Mikhail G. SHAPIRO , Di WU , Gunho KIM , Robert H. GRUBBS , Ki-Young YOON
CPC分类号： B29C61/06 , A61L31/14 , A61L31/128 , A61L2400/16 , B29K2995/0012 , B29K2509/02
摘要： Aspects disclosed herein include a composite material comprising: one or more shape memory polymers; and a first additive provided in the shape memory polymer(s); wherein: the first additive increases one or more ultrasound-absorption characteristics of the composite material compared to that of the same shape memory polymer(s) free of said first additive; the composite material is characterized by a composite transition temperature (Tcm,trans); and the composite material or one or more portions thereof undergo a shape change from a temporary shape to a permanent shape when the composite material or said one or more portions thereof are heated to within 35° C. of Tcm,trans or a temperature approximately equal to or greater than Tcm,trans.
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公开(公告)号：US20210053043A1
公开(公告)日：2021-02-25
申请号：US17094004
申请日：2020-11-10
发明人： Adam M. JOHNS , T. Patrick MONTGOMERY , Tonia S. AHMED , Robert H. GRUBBS , Richard L. PEDERSON
摘要： This invention relates generally to metathesis catalysts and the use of such catalysts in the metathesis of olefins and olefin compounds, more particularly, in the use of such catalysts in Z and E selective olefin metathesis reactions. The invention has utility in the fields of organometallics and organic synthesis.
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公开(公告)号：US20200373622A1
公开(公告)日：2020-11-26
申请号：US16897771
申请日：2020-06-10
发明人： Simon C. JONES , Victoria K. DAVIS , Christopher M. BATES , Nebojsa MOMCILOVIC , Brett M. SAVOIE , Michael A. WEBB , Thomas F. MILLER, III , Robert H. GRUBBS , Christopher BROOKS , Kaoru OMICHI
IPC分类号： H01M10/0568 , H01M10/0525 , H01M10/0569 , H01M10/054 , C07C209/68
摘要： Electrolyte solutions including at least one anhydrous fluoride salt and at least one non-aqueous solvent are presented. The fluoride salt includes an organic cation having a charge center (e.g., N, P, S, or O) that does not possess a carbon in the β-position or does not possess a carbon in the β-position having a bound hydrogen. This salt structure facilitates its ability to be made anhydrous without decomposition. Example anhydrous fluoride salts include (2,2-dimethylpropyl)trimethylammonium fluoride and bis(2,2-dimethylpropyl)dimethylammonium fluoride. Combining these fluoride salts with at least one fluorine-containing non-aqueous solvent (e.g., bis(2,2,2-trifluoroethyl)ether; (BTFE)) promotes solubility of the salt within the non-aqueous solvents. The solvent may be a mixture of at least one non-aqueous, fluorine-containing solvent and at least one other non-aqueous, fluorine or non-fluorine containing solvent (e.g., BTFE and propionitrile or dimethoxyethane). The electrolyte solutions may be employed in electrochemical cells, such as batteries, fuel cells, electrolysis systems, and capacitors.
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公开(公告)号：US20200330970A1
公开(公告)日：2020-10-22
申请号：US16919704
申请日：2020-07-02
发明人： Adam M. Johns , Jessica R. HERRON , Richard L. PEDERSON , Bryan A. FIAMENGO , Jennifer A. BEERMAN , Tzu-Pin LIN , Crystal K. CHU , Robert H. GRUBBS
摘要： This invention relates generally to olefin metathesis catalyst compounds, to the preparation of such compounds, compositions comprising such compounds, methods of using such compounds, articles of manufacture comprising such compounds, and the use of such compounds in the metathesis of olefins and olefin compounds. The invention has utility in the fields of catalysts, organic synthesis, polymer chemistry, and industrial and fine chemicals industry.
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