公开(公告)号：US20250082869A1

公开(公告)日：2025-03-13

申请号：US18726062

申请日：2022-11-07

Applicant: CANSINO BIOLOGICS INC. ,  STAMFORD DEVICES LIMITED

Inventor： Weixue SI ,  Xiaolong ZHAO ,  Yueran WANG ,  Yueying JIANG ,  Liping WANG ,  Xuefeng YU ,  Shoubai CHAO ,  Tao ZHU

IPC: A61M11/00

Abstract: Disclosed are a nebulization cup and application in nebulized inhalation administration thereof, and especially application in nebulized inhalation administration of a preventive and/or therapeutic drug for a respiratory disease (such as SARS-CoV-2 vaccine). After adding an antistatic agent, the nebulization cup can effectively maintain the stability of drug mist within a certain period of time, with stable particle size, less drug residue in the cup, thus ensuring effective inhalable amount, and the administration operation is simple and convenient, thus the nebulization cup can significantly improve the inoculation efficiency and can be used for large-scale inoculation.

公开(公告)号：US20200255862A1

公开(公告)日：2020-08-13

申请号：US16806013

申请日：2020-03-02

Applicant: CANSINO BIOLOGICS INC.

Inventor： Tao ZHU ,  Haiyan CUI ,  Weiwei CHEN ,  Lei DUAN ,  Junqiang LI ,  Jin MA ,  Chunlin XIN ,  Zhongqi SHAO ,  Xuefeng YU ,  Huihua MAO

IPC: C12N15/86 ,  A61K39/235

Abstract: Provided are a cell strain HEK293.CS for reducing the production of a replication competent adenovirus, and a construction method and the use thereof. HEK293.CS is a safe adenovirus-producing cell line constructed by knocking out a gene fragment homologous to the Ad5 adenovirus E1 gene in HEK293 and providing a template plasmid to replace said gene fragment with a non-homologous sequence that stabilizes the expression of the E1 gene. Compared with the unmodified HEK293 cell strain, HEK293.CS shows no decrease in growth ability and virus production ability, but does not produce a detectable RCA. HEK293.CS can be used for the mass culture of a recombinant human type 5 adenovirus, and reducing the probability of RCA production in the manufacture process of drugs such as vaccines and antibodies.

公开(公告)号：US20180296660A1

公开(公告)日：2018-10-18

申请号：US15582400

申请日：2017-04-28

Applicant: CANSINO BIOLOGICS INC.

Inventor： Tao ZHU ,  Lei DUAN ,  Mingming YANG ,  Zhongqi SHAO ,  Xuefeng YU ,  Helen Huihua MAO ,  Dongxu QIU

IPC: A61K39/09 ,  A61K39/116 ,  A61P31/04

CPC classification number: A61K39/092 ,  A61K39/001164 ,  A61K39/116 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/55588 ,  A61P31/04

Abstract: The invention provides an immunogenic composition for preventing pneumococcal diseases, comprising PspA-MRXI, PspA-EF5668, PspA-EF3296 and PlyL460D, wherein the amount of each component is 10-100 μg/ml; the immunogenic composition is prepared by adding to aluminum adjuvant the corresponding dosages of the four stock solutions PspA-mRXI, PspA-EF5668, PspA-EF3296 and PlyL460D, and mixing them homogeneously; the immunogenic composition can prevent infection and invasion by Streptococcus pneumonia, covering more than 95% of the strains in clinic. The immunogenic composition has a wide application in the prevention of pneumonia, and is suitable for large-scale production in industry for its simple preparation method, low production cost, and short production cycle.

公开(公告)号：US20180214541A1

公开(公告)日：2018-08-02

申请号：US15940871

申请日：2018-03-29

Applicant: CANSINO BIOLOGICS INC.

Inventor： Junqiang LI ,  Danqing MIAO ,  Mingming YANG ,  Zhongqi SHAO ,  Tao ZHU ,  Xuefeng YU

IPC: A61K39/385 ,  A61K39/102 ,  A61K47/64

Abstract: Provided are a fusion protein and a construction method thereof. The fusion method consists of: a Haemophilus influenzae protein D and a Hin47 (Htra) protein. The fusion protein can serve as a protein vehicle for a Haemophilus influenzae polysaccharide-protein conjugate vaccine, thereby increasing immunogenicity of a polysaccharide antigen.