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公开(公告)号：US20250058059A1
公开(公告)日：2025-02-20
申请号：US18720321
申请日：2022-11-30
Applicant: STAMFORD DEVICES LIMITED
Inventor： Joseph GREHAN , Aidan DUFFY , Anthony REDMOND
IPC: A61M11/00
Abstract: A nebulizer (1, 102) has a liquid reservoir (3, 112) for supply of liquid to be aerosolized to a first surface of a vibratable aperture plate (41) with apertures having a size in the range of 1 pm to 10 pm. A drive has a piezoelectric annular element on an aperture plate support to cause the aperture plate to vibrate at a drive frequency of 128 kHz to cause droplets to separate from a side of the aperture plate opposed to the reservoir. An outlet conduit (6, 114) is for flow of droplets from the aperture plate. A sensor is arranged with an acoustic transducer in contact with the conduit outer surface to pick up an acoustic signal which is representative of a droplet plume in the conduit, and a processor analyses the signal to provide an output representative of a plume. The monitored acoustic signal frequency band is centred around half of the drive frequency because it takes on average more than one aperture plate cycle to separate a droplet.
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公开(公告)号：US20240344226A1
公开(公告)日：2024-10-17
申请号：US18411467
申请日：2024-01-12
Applicant: Stamford Devices Limited
Inventor： Hong XU
IPC: C25D7/00 , A61M11/00 , B05B17/00 , B41J2/16 , C25D1/00 , C25D3/38 , C25D3/46 , C25D3/48 , C25D3/54 , C25D5/00 , C25D5/02 , C25D5/10 , C25D5/34 , C25D5/48 , C25D5/54
CPC classification number: C25D7/00 , A61M11/005 , B05B17/0646 , B41J2/162 , B41J2/1625 , B41J2/1629 , B41J2/1631 , C25D1/003 , C25D3/38 , C25D3/46 , C25D3/48 , C25D3/54 , C25D5/022 , C25D5/10 , C25D5/34 , C25D5/48 , C25D5/54 , C25D5/611
Abstract: In one embodiment, a method for manufacturing an aperture plate includes depositing a releasable seed layer above a substrate, applying a first patterned photolithography mask above the releasable seed layer, the first patterned photolithography mask having a negative pattern to a desired aperture pattern, electroplating a first material above the exposed portions of the releasable seed layer and defined by the first mask, applying a second photolithography mask above the first material, the second photolithography mask having a negative pattern to a first cavity, electroplating a second material above the exposed portions of the first material and defined by the second mask, removing both masks, and etching the releasable seed layer to release the first material and the second material. The first and second material form an aperture plate for use in aerosolizing a liquid. Other aperture plates and methods of producing aperture plates are described according to other embodiments.
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公开(公告)号：US20240001048A1
公开(公告)日：2024-01-04
申请号：US18314637
申请日：2023-05-09
Applicant: Stamford Devices Limited
Inventor： Brendan HOGAN
CPC classification number: A61M11/003 , C25D1/08 , A61M11/005 , C25D7/00 , C25D3/567
Abstract: A photo-resist (21) is applied in a pattern or vertical columns having the dimensions of holes or pores of the aperture plate to be produced. This mask pattern provides the apertures which define the aerosol particle size, having up to 2500 holes per square mm. There is electro-deposition of metal (22) into the spaces around the columns (21). There is further application of a second photo-resist mask (25) of much larger (wider and taller) columns, encompassing the area of a number of first columns (21). The hole diameter in the second plating layer is chosen according to a desired flow rate.
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公开(公告)号：US20230285704A1
公开(公告)日：2023-09-14
申请号：US18040163
申请日：2021-08-20
Applicant: STAMFORD DEVICES LIMITED
Inventor： John POWER , Aidan DUFFY , Micheal CASEY
CPC classification number: A61M16/0677 , A61M16/0622 , A61M16/16 , A61M16/0096 , A61M16/1075 , A61M16/1005 , A61M16/022 , A61M16/1055 , A61M16/0093 , A61M16/20 , A61M2016/0027 , A61M2205/3334 , A61M2205/3337
Abstract: A patient interface (1) is for aerosol treatment, having a base (2) to surround the patients mouth and nose and engage the skin with a resilient seal, and with a strap (8) to attach to a patients head. There is a support (3) on and across the base for supporting an aerosol delivery head with prongs (4, 5). An enclosed volume is formed in the interface by attachment of a shell (10), which has an extraction port (11) for attachment of an extraction system (20) to extract gas from this volume. An HFNT system includes a patient interface surrounding the nose and mouth and an aerosol delivery apparatus (4, 6), an extraction apparatus (20), and a controller (100) to control delivery of aerosol and/or gas to the interface and to extract gases from a volume enclosed by the interface. Because of the fully sealed volume within the interface there are a wide range of control scenarios possible, using pressure sensing in the volume, bypass valves (201), dynamically-controllable nebulizer (203).
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公开(公告)号：US20230166284A1
公开(公告)日：2023-06-01
申请号：US18161462
申请日：2023-01-30
Applicant: STAMFORD DEVICES LIMITED
Inventor： Michael AHERNE , Colga COYE , Philip SCANLON
IPC: B05B17/00
CPC classification number: B05B17/0646
Abstract: An aperture plate (1) is attached at its rim (203) to a support washer (3) by adhesive. Anchor grooves (204) having a zig-zag pattern in plan are machined in the lower surface of the rim (203 of the aperture plate before application of the adhesive. The grooves (204) extend out to the edge of the aperture plate (1). The anchor grooves have a depth in the range of 10 μm to 40 μm, and a width in the range of 20 μm to 150 μm, and an angular pitch in the range of 2.5° to 12.5°. Excellent bonding strength is achieved for long term reliable attachment in an environment of high frequency vibration and moisture and chemical corrosion.
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Patent Agency Ranking
公开(公告)号：US20230133932A1
公开(公告)日：2023-05-04
申请号：US18061564
申请日：2022-12-05
Applicant: STAMFORD DEVICES LIMITED
Inventor： Ronan MACLOUGHLIN , Shaun PORTER , Conor DUFFY , John POWER
Abstract: A gas therapy system (1) has a flow line (3, 2), a coupler (6) to a gas source, and an aerosol generator (4) for aerosol delivery, and a patient interface such as a nasal interface (2). A controller (10) is configured to modulate gas flow and aerosol delivery in real time. The controller changes gas flow rate and dynamically reduces aerosol delivery during upper gas flow rates such as 60 LPM, and activates aerosol delivery during lower gas flow rates of for example 10 LPM. The control may also include sensors to detect breathing, so that there is a bias towards increased aerosol delivery during inhalation in addition to during lower level gas flow.
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公开(公告)号：US11534570B2
公开(公告)日：2022-12-27
申请号：US16621560
申请日：2018-07-03
Applicant: STAMFORD DEVICES LIMITED
Inventor： Ronan MacLoughlin , Shaun Porter , Conor Duffy , John Power
Abstract: A gas therapy system (1) has a flow line (3, 2), a coupler (6) to a gas source, and an aerosol generator (4) for aerosol delivery, and a patient interface such as a nasal interface (2). A controller (10) is configured to modulate gas flow and aerosol delivery in real time. The controller changes gas flow rate and dynamically reduces aerosol delivery during upper gas flow rates such as 60 LPM, and activates aerosol delivery during lower gas flow rates of for example 10 LPM. The control may also include sensors to detect breathing, so that there is a bias towards increased aerosol delivery during inhalation in addition to during lower level gas flow.
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公开(公告)号：US11433189B2
公开(公告)日：2022-09-06
申请号：US16853039
申请日：2020-04-20
Applicant: Stamford Devices Limited
Inventor： Patrick Power
Abstract: An aerosol delivery system has a nebulizer and a humidifier providing a gas flow to the nebulizer. A controller varies humidity level of the gas flow to the nebulizer so that if the nebulizer is not operating it has about 100% humidity and it is operating the value is less to allow for the humidification effect of the nebulizer. The control may be achieved by dynamically varying proportions of flow through a dry branch and a humidification branch.
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公开(公告)号：US20220016365A1
公开(公告)日：2022-01-20
申请号：US17371412
申请日：2021-07-09
Applicant: Stamford Devices Limited
Inventor： John POWER , Ronan MacLOUGHLIN , Michael CASEY , Conor DUFFY , Aidan DUFFY
IPC: A61M15/00
Abstract: A dispensing apparatus is for use by users to take a chamber, fill the chamber with an aerosolized vaccine or other medicament, and dispose of used chambers. A display provides instructions to encourage prompt inhalation by the user from a dispensed and filled chamber. The apparatus allows very fast administration of vaccines to large numbers of people. The aerosol dispenser apparatus detects the chamber is in correct position and delivers a pre-determined dose of aerosol. Once the dose is delivered a visual and/or audible indicator informs the user that the chamber is filled and that they can take the inhalation. The single dose aerosol chamber is optimized for efficient administration of an aerosol.
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公开(公告)号：US20220008672A1
公开(公告)日：2022-01-13
申请号：US17293203
申请日：2018-12-06
Applicant: STAMFORD DEVICES LIMITED
Inventor： Stefan KERN
Abstract: A coupling part with integrated aerosol generator for use in a breathing circuit, comprising a housing (10) enclosing a cavity (V), having a first opening at a first end prepared for direct or indirect connection to a ventilator, a second opening at a second end, which is suitable for direct or indirect connection to a patient line or an endotracheal tube, wherein an aerosol generator (20) is integrated in one side of the housing and is suitable for delivering an aerosolised liquid, in particular a medicament.
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