公开(公告)号：US20160263545A1

公开(公告)日：2016-09-15

申请号：US14871287

申请日：2015-09-30

申请人： CARDINAL HEALTH 414, LLC

发明人： DENNIS ESHIMA ,  MEHMET HUSNU ,  JIM STONE ,  DERRICK ALCAIDE ,  JOSEPH E. ZAMBANINI ,  THOMAS A. KLAUSING ,  CHAD E. BOUTON ,  HENRY PADGETT ,  BRIAN C. KELLEY ,  SCOTT N. DANHOF ,  DAVID A. HOLLEY ,  JEFFREY T. STROUP ,  JAMES B. GLEESON ,  ERIC HASSENPFLUG ,  JAMES A. PRESCOTT ,  HERMAN BENECKE ,  DANIEL B. GARBARK

IPC分类号： B01J19/00

CPC分类号： B01J19/0006 ,  A61J3/002 ,  A61K51/0491 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00049 ,  B01J2219/00351 ,  B01J2219/00355 ,  B01J2219/00585 ,  B01J2219/00693 ,  B01J2219/00702 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00759 ,  B65B1/00 ,  B65B3/003 ,  G21G1/10 ,  G21G2001/0015

摘要： Systems, methods, and devices for generating radionuclides for use in production of radiopharmaceuticals; synthesizing the radionuclides generated and removing any unwanted products; measuring the quantity and activity level of the synthesized radionuclides; distributively delivering the radionuclides in appropriate quantities to modular cassette synthesis units in a modular cassette subsystem for contemporaneous/parallel production of radiopharmaceutical output and that allow reuse and/or quick, safe, and disposable replacement of portions of the subsystem; delivering non-radionuclide components to the modular cassette synthesis units as part of production of radiopharmaceutical output; measuring the quantity and activity level of each stream of radiopharmaceutical output; purifying the radiopharmaceutical output; dispensing individual doses in sterile vial(s); automatically producing labeling and dose related information; performing automated quality control on extracted samples of produced radiopharmaceutical output; and providing software and hardware controls for overall and sub-portion operation for optional remote data collection, communication, and/or control.

摘要翻译： 用于产生用于放射性药物生产的放射性核素的系统，方法和装置; 合成生成的放射性核素并除去任何不需要的产物; 测量合成放射性核素的数量和活度水平; 将放射性核素分配递送到模块化盒式系统中的模块化盒式合成单元，用于同时/并行生产放射性药物输出，并允许重复使用和/或快速，安全和一次性更换子系统的一部分; 将非放射性核素组分作为放射性药物输出生产的一部分提供给模块化盒式合成单元; 测量每个放射性药物输出流量的数量和活动水平; 净化放射性药物输出; 在无菌小瓶中分配单个剂量; 自动生成标签和剂量相关信息; 对提取的放射性药物输出样品进行自动化质量控制; 并为可选的远程数据收集，通信和/或控制提供用于整体和子部分操作的软件和硬件控制。

公开(公告)号：US20160001246A1

公开(公告)日：2016-01-07

申请号：US14635343

申请日：2015-03-02

申请人： CARDINAL HEALTH 414, LLC

发明人： THOMAS A. KLAUSING ,  BRIAN C. KELLEY ,  JOSEPH E. ZAMBANINI ,  DAVID A. HOLLEY ,  JEFFREY T. STROUP

IPC分类号： B01J19/00 ,  G05B15/02

CPC分类号： B01J19/004 ,  B01J19/0093 ,  B01J2219/00006 ,  B01J2219/0002 ,  G05B15/02

摘要： Compact modular cassette systems and methods for the synthesis of radiopharmaceutical products are provided, the compact modular cassette system including a modular unit having valve plates, a reaction cassette, a reagent pack, and other seal and connector plates to ensure that reagents can be mixed together inside one or more chambers of the reaction cassette in a timely and efficient manner. When a new chamber for each new reaction or process should be used, a valveless modular system having removable reaction cassettes and the reagent packs may be used. In such a system, the reagent container, the reaction cassette, or both, can be removed from the modular cassette system and discarded after a desired reaction or process has taken place.