公开(公告)号：US20160263545A1

公开(公告)日：2016-09-15

申请号：US14871287

申请日：2015-09-30

申请人： CARDINAL HEALTH 414, LLC

发明人： DENNIS ESHIMA ,  MEHMET HUSNU ,  JIM STONE ,  DERRICK ALCAIDE ,  JOSEPH E. ZAMBANINI ,  THOMAS A. KLAUSING ,  CHAD E. BOUTON ,  HENRY PADGETT ,  BRIAN C. KELLEY ,  SCOTT N. DANHOF ,  DAVID A. HOLLEY ,  JEFFREY T. STROUP ,  JAMES B. GLEESON ,  ERIC HASSENPFLUG ,  JAMES A. PRESCOTT ,  HERMAN BENECKE ,  DANIEL B. GARBARK

IPC分类号： B01J19/00

CPC分类号： B01J19/0006 ,  A61J3/002 ,  A61K51/0491 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00049 ,  B01J2219/00351 ,  B01J2219/00355 ,  B01J2219/00585 ,  B01J2219/00693 ,  B01J2219/00702 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00759 ,  B65B1/00 ,  B65B3/003 ,  G21G1/10 ,  G21G2001/0015

摘要： Systems, methods, and devices for generating radionuclides for use in production of radiopharmaceuticals; synthesizing the radionuclides generated and removing any unwanted products; measuring the quantity and activity level of the synthesized radionuclides; distributively delivering the radionuclides in appropriate quantities to modular cassette synthesis units in a modular cassette subsystem for contemporaneous/parallel production of radiopharmaceutical output and that allow reuse and/or quick, safe, and disposable replacement of portions of the subsystem; delivering non-radionuclide components to the modular cassette synthesis units as part of production of radiopharmaceutical output; measuring the quantity and activity level of each stream of radiopharmaceutical output; purifying the radiopharmaceutical output; dispensing individual doses in sterile vial(s); automatically producing labeling and dose related information; performing automated quality control on extracted samples of produced radiopharmaceutical output; and providing software and hardware controls for overall and sub-portion operation for optional remote data collection, communication, and/or control.

摘要翻译： 用于产生用于放射性药物生产的放射性核素的系统，方法和装置; 合成生成的放射性核素并除去任何不需要的产物; 测量合成放射性核素的数量和活度水平; 将放射性核素分配递送到模块化盒式系统中的模块化盒式合成单元，用于同时/并行生产放射性药物输出，并允许重复使用和/或快速，安全和一次性更换子系统的一部分; 将非放射性核素组分作为放射性药物输出生产的一部分提供给模块化盒式合成单元; 测量每个放射性药物输出流量的数量和活动水平; 净化放射性药物输出; 在无菌小瓶中分配单个剂量; 自动生成标签和剂量相关信息; 对提取的放射性药物输出样品进行自动化质量控制; 并为可选的远程数据收集，通信和/或控制提供用于整体和子部分操作的软件和硬件控制。

公开(公告)号：US09287015B2

公开(公告)日：2016-03-15

申请号：US13576446

申请日：2011-01-26

申请人： Arnd Baurichter ,  Oliver Heid ,  Timothy Hughes

发明人： Arnd Baurichter ,  Oliver Heid ,  Timothy Hughes

IPC分类号： G21G1/00 ,  G21G1/10 ,  H05H6/00

CPC分类号： G21G1/10 ,  G21G2001/0015 ,  G21G2001/0036 ,  G21G2001/0042 ,  H05H6/00

摘要： A method is provided for producing first and second radioactive isotopes using an accelerated particle beam that is directed to a first material and the first radioactive isotope is produced by a first nuclear reaction based on the interaction of the particle beam with the first material, said particle beam is also slowed down and subsequently directed to a second material, and the second radioactive isotope is produced by a second nuclear reaction based on the interaction of the particle beam with the second material. The effective cross-section for the induction of the first nuclear reaction at a first peak for a first particle energy is higher than an effective cross-section for the induction of the second nuclear reaction at a second peak for a second particle energy. A corresponding device includes an acceleration unit, a first exposure target having the first material and a second exposure target having the second material.

摘要翻译： 提供了一种使用引导到第一材料的加速粒子束来产生第一和第二放射性同位素的方法，并且基于粒子束与第一材料的相互作用，通过第一核反应产生第一放射性同位素，所述粒子 梁也被放慢并且随后被引导到第二材料，并且第二放射性同位素是通过基于粒子束与第二材料的相互作用的第二核反应产生的。 用于第一粒子能量的第一个峰值处的第一次核反应的有效截面高于用于第二个粒子能量的第二个峰值处的第二次核反应的有效截面。 对应的装置包括加速单元，具有第一材料的第一曝光目标和具有第二材料的第二曝光对象。

公开(公告)号：US09269466B2

公开(公告)日：2016-02-23

申请号：US14458671

申请日：2014-08-13

申请人： GENERAL ELECTRIC COMPANY

发明人： Jonas Norling ,  Tomas Eriksson

IPC分类号： G21G1/00 ,  G21G1/10 ,  H05H6/00

CPC分类号： G21G1/0005 ,  G21G1/10 ,  G21G2001/0015 ,  H05H6/00

摘要： Isotope production system including a particle accelerator configured to produce a particle beam. The isotope production system also includes a target apparatus having a window configured to receive a particle beam and also separate production and condensing chambers. The production chamber is configured to contain a starting liquid and located so that the particle beam is incident upon the starting liquid thereby generating radioisotopes and transforming a portion of the starting liquid into vapor. The target apparatus also includes a fluid channel that extends between and fluidly couples the production and condensing chambers. The fluid channel is configured to allow the vapor to flow from the production chamber into the condensing chamber. The condensing chamber is configured to transform the vapor in the condensing chamber into a condensed liquid.

摘要翻译： 包括构造成产生粒子束的粒子加速器的同位素生产系统。 同位素生产系统还包括具有构造成接收粒子束并且还分离生产和冷凝室的窗口的目标装置。 生产室被配置为容纳起始液体并且定位成使得粒子束入射到起始液体上，从而产生放射性同位素并将起始液体的一部分转化为蒸气。 目标装置还包括在生产和冷凝室之间延伸并流体连接生产和冷凝室的流体通道。 流体通道构造成允许蒸气从制备室流入冷凝室。 冷凝室被配置成将冷凝室中的蒸汽转化为冷凝液体。

公开(公告)号：US20140362964A1

公开(公告)日：2014-12-11

申请号：US14458671

申请日：2014-08-13

申请人： GENERAL ELECTRIC COMPANY

发明人： JONAS NORLING ,  TOMAS ERIKSSON

IPC分类号： G21G1/00

CPC分类号： G21G1/0005 ,  G21G1/10 ,  G21G2001/0015 ,  H05H6/00

摘要： Isotope production system including a particle accelerator configured to produce a particle beam. The isotope production system also includes a target apparatus having a window configured to receive a particle beam and also separate production and condensing chambers. The production chamber is configured to contain a starting liquid and located so that the particle beam is incident upon the starting liquid thereby generating radioisotopes and transforming a portion of the starting liquid into vapor. The target apparatus also includes a fluid channel that extends between and fluidly couples the production and condensing chambers. The fluid channel is configured to allow the vapor to flow from the production chamber into the condensing chamber. The condensing chamber is configured to transform the vapor in the condensing chamber into a condensed liquid.

摘要翻译： 包括构造成产生粒子束的粒子加速器的同位素生产系统。 同位素生产系统还包括具有构造成接收粒子束并且还分离生产和冷凝室的窗口的目标装置。 生产室被配置为容纳起始液体并且定位成使得粒子束入射到起始液体上，从而产生放射性同位素并将起始液体的一部分转化为蒸气。 目标装置还包括在生产和冷凝室之间延伸并流体连接生产和冷凝室的流体通道。 流体通道构造成允许蒸气从制备室流入冷凝室。 冷凝室被配置成将冷凝室中的蒸汽转化为冷凝液体。

公开(公告)号：US20120145557A1

公开(公告)日：2012-06-14

申请号：US13377881

申请日：2010-07-12

申请人： Marko Baller ,  Victor Samper ,  Christian Rensch ,  Christoph Boeld

发明人： Marko Baller ,  Victor Samper ,  Christian Rensch ,  Christoph Boeld

IPC分类号： C25B15/00 ,  B29C45/00 ,  C25B11/12 ,  C25B9/06 ,  H01B1/24 ,  C01B31/00

CPC分类号： G21G1/001 ,  G21G2001/0015

摘要： Devices and methods for electrochemical phase transfer utilize at least one electrode formed from either glassy carbon or a carbon and polymer composite. The device includes a device housing defining an inlet port (42), an outlet port (44) and an elongate fluid passageway (36) extending therebetween. A capture electrode (12) and a counter electrode are positioned within said housing such that the fluid passageway extends between the capture and counter electrodes.

摘要翻译： 用于电化学相转移的装置和方法利用由玻璃碳或碳和聚合物复合材料形成的至少一个电极。 该装置包括限定入口端口（42），出口端口（44）和在其间延伸的细长流体通道（36）的装置壳体。 捕获电极（12）和对电极位于所述壳体内，使得流体通道在捕获电极和对电极之间延伸。

公开(公告)号：US07831009B2

公开(公告)日：2010-11-09

申请号：US10671086

申请日：2003-09-25

申请人： Charles W. Alvord ,  Andy Williamson

发明人： Charles W. Alvord ,  Andy Williamson

IPC分类号： G21G1/10

CPC分类号： H05H6/00 ,  G21G1/10 ,  G21G2001/0015

摘要： An apparatus for containing and cooling enriched water for the production of activated fluorine (18F). A target assembly includes internal cooling channels in which developed flow of a coolant removes the heat from the target liquid in the target chamber. In one embodiment, the target assembly is fabricated of tantalum.

摘要翻译： 用于容纳和冷却用于生产活性氟（18F）的富集水的装置。 目标组件包括内部冷却通道，其中冷却剂的流出物从目标室中的目标液体中除去热量。 在一个实施例中，靶组件由钽制成。

公开(公告)号：US20180025801A1

公开(公告)日：2018-01-25

申请号：US15521207

申请日：2015-10-22

申请人： The University of Hull

发明人： Stephen James Archibald ,  Ping He ,  Stephen John Haswell ,  Nicole Pamme ,  Nathan Joel Brown ,  Mark Duncan Tarn ,  Richard Alexander

IPC分类号： G21G1/00 ,  A61K51/04 ,  B01D57/02

CPC分类号： G21G1/001 ,  A61K51/0491 ,  B01D57/02 ,  G21G2001/0015

摘要： The present invention relates to a method and an apparatus for separating and recovering a radioisotope from a solution. More particularly, certain embodiments of the invention relate to a method for recovering a radioisotope from a solution by electro-trapping and release using a microfluidic cell (10). The radioisotope may subsequently be used in the preparation of radiopharmaceuticals.

公开(公告)号：US20170213614A1

公开(公告)日：2017-07-27

申请号：US15325014

申请日：2015-07-09

申请人： NANOMARKER SPRL

发明人： Milo Conard

IPC分类号： G21K5/08 ,  H05H13/00 ,  C25D1/00 ,  G21G1/10

CPC分类号： G21K5/08 ,  C25D1/003 ,  G21G1/10 ,  G21G2001/0015 ,  H05H6/00 ,  H05H13/005

摘要： The invention relates to a container (100, 901, 902, 903, 904, 905, 906, 907, 908, 909, 910) for the production of radioisotopes by irradation of a precursor material formed by a one-piece metal casing, the wall of said casing including one thin portion (130) having a thickness of between 5 and 100 μm, the remainder having a thickness greater than 100 μm. The invention also relates to a method for obtaining the container and to a target assembly using same.

公开(公告)号：US20170200520A1

公开(公告)日：2017-07-13

申请号：US15470513

申请日：2017-03-27

申请人： Taylor Ramon WILSON

发明人： Taylor Ramon WILSON

IPC分类号： G21G1/00 ,  H05H1/46 ,  G21G1/02

CPC分类号： G21G1/001 ,  G21F3/00 ,  G21G1/02 ,  G21G1/04 ,  G21G1/10 ,  G21G2001/0015 ,  H01J37/08 ,  H01J2237/164 ,  H05H1/46

摘要： A dense plasma focus (DPF) to produce positron emitters is provided, where a pulsed device has an anode and a cathode arranged in a vacuum chamber, the anode and cathode being subjected to a high voltage. When the vacuum chamber is filled with a reaction gas and a high voltage generated is applied, a plasma sheath is created and a reaction between the electrodes take place to produce plasmoids resulting in an ion beam that interacts with a reactive gas to produce radio-isotopes.

公开(公告)号：US09414479B2

公开(公告)日：2016-08-09

申请号：US13701294

申请日：2011-05-31

申请人： Bernard Lambert ,  Jean-Michel Geets ,  Jozef J. Comor ,  Djuro Jovanovic

发明人： Bernard Lambert ,  Jean-Michel Geets ,  Jozef J. Comor ,  Djuro Jovanovic

IPC分类号： G21G1/00 ,  H05H6/00 ,  G21K5/00 ,  G21G1/10

CPC分类号： H05H6/00 ,  G21G1/10 ,  G21G2001/0015 ,  G21G2001/0063 ,  G21K5/00 ,  Y10T29/4973

摘要： The present invention relates to an apparatus for producing a radioisotope by irradiating a target fluid comprising a precursor of said radioisotope with a particle beam produced by a particle accelerator, the apparatus comprising: —a housing comprising a target cavity for receiving said target fluid, said housing having an opening for allowing the passage of the said particle beam into the said cavity; —a dual foil flange for closing said opening of the target cavity, said dual foil flange comprising: —a standoff comprising a central hole; —a first and a second foil able to allow the passage of the said particle beam and located respectively on a first side and a second side of the said standoff, covering the said central hole and forming a cooling cavity; —a first flange and a second flange for sealing respectively the said first and second foil on said standoff; —at least an inlet channel and at least an outlet channel, for flowing a cooling fluid through the cavity of the dual foil flange; —guiding means for positioning said dual foil flange in an in-line position in which a said foil is facing said opening of said housing.

摘要翻译： 本发明涉及一种通过用粒子加速器产生的粒子束照射包括所述放射性同位素的前体的靶流体来生产放射性同位素的装置，所述装置包括： - 包括用于接收所述目标流体的目标腔的壳体， 壳体具有用于允许所述粒子束通过所述空腔的开口; - 用于封闭所述目标腔的所述开口的双箔凸缘，所述双箔凸缘包括： - 包括中心孔的支座; - 第一和第二箔，其能够允许所述粒子束通过并分别位于所述支座的第一侧和第二侧上，覆盖所述中心孔并形成冷却腔; - 第一凸缘和第二凸缘，用于在所述支座上分别密封所述第一和第二箔; - 至少一个入口通道和至少一个出口通道，用于使冷却流体流过双箔凸缘的空腔; 用于将所述双箔法兰定位在其中所述箔面对所述壳体的所述开口的在线位置的引导装置。