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1.发明申请公开(公告)号：US20180312886A1
公开(公告)日：2018-11-01
申请号：US16030262
申请日：2018-07-09
申请人： CARGILL INCORPORATED
IPC分类号： C12P7/64 , C12N15/70 , C07C53/126 , C12P13/14 , C12N9/02 , C12P7/52 , C12P7/42 , C12P7/22 , C12P7/00 , C12N9/10 , C12P7/62
摘要： Metabolically engineered microorganism strains are disclosed, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product. Such chemical products include polyketides, 3-hydroxypropionic acid, and various other chemical products described herein. Methods of production also may be applied to further downstream products, such as consumer products. In various embodiments, modifications to a microorganism and/or culture system divert, at least transiently, usage of malonyl-coA from the fatty acid biosynthesis pathway and thereby provides for usage of the malonyl-coA for a chemical product other than a fatty acid. In various embodiments, the fatty acid biosynthesis pathway is modulated to produce specific fatty acids or combinations of fatty acids.
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公开(公告)号：US09944959B2
公开(公告)日：2018-04-17
申请号：US14843525
申请日：2015-09-02
发明人： Katrin Grammann , Jan Wolter , Liv Reinecke , Steffen Schaffer , Eileen C. Spindler , Wendy K. Ribble , Brittany L. Prather , Catherine B. Poor , Tanya Warnecke Lipscomb , Hans H. Liao , Dave A. Hogsett , Ronald J. Evans
CPC分类号： C12P7/6436 , C12N9/1029 , C12Y203/01041 , C12Y203/01075
摘要： A microbial cell is used for producing at least one fatty acid ester, wherein the cell is genetically modified to contain (i) at least one first genetic mutation that enables the cell to produce at least one fatty acid and/or acyl coenzyme A (CoA) thereof by increased enzymatic activity in the cell relative to the wild type cell of malonyl-CoA dependent and malonyl-ACP independent fatty acyl-CoA metabolic pathway, wherein the fatty acid contains at least 5 carbon atoms; and (ii) a second genetic mutation that increases the activity of at least one wax ester synthase in the cell relative to the wild type cell and the wax ester synthase has sequence identity of at least 50% to a polypeptide of SEQ ID NO: 1-8 and combinations thereof or to a functional fragment of any of the polypeptides for catalyzing the conversion of fatty acid and/or acyl coenzyme A thereof to the fatty acid ester.
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3.发明申请公开(公告)号：US20180312887A1
公开(公告)日：2018-11-01
申请号：US16030300
申请日：2018-07-09
申请人： CARGILL INCORPORATED
IPC分类号： C12P7/64 , C12N15/70 , C07C53/126 , C12P13/14 , C12N9/02 , C12P7/52 , C12P7/42 , C12P7/22 , C12P7/00 , C12N9/10 , C12P7/62
摘要： Metabolically engineered microorganism strains are disclosed, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product. Such chemical products include polyketides, 3-hydroxypropionic acid, and various other chemical products described herein. Methods of production also may be applied to further downstream products, such as consumer products. In various embodiments, modifications to a microorganism and/or culture system divert, at least transiently, usage of malonyl-coA from the fatty acid biosynthesis pathway and thereby provides for usage of the malonyl-coA for a chemical product other than a fatty acid. In various embodiments, the fatty acid biosynthesis pathway is modulated to produce specific fatty acids or combinations of fatty acids.
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