公开(公告)号：US20170157069A1

公开(公告)日：2017-06-08

申请号：US15440738

申请日：2017-02-23

Applicant: CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

Inventor： Mi-La CHO ,  Seon-Yeong LEE ,  Min-Jung PARK ,  Jae-Seon LEE ,  Eun-Ji YANG ,  Eun-Kyung KIM ,  Jun-Geol RYU ,  Hye-Jin SON

IPC: A61K31/155

CPC classification number: A61K31/155

Abstract: The present invention relates to a composition for preventing or treating immune diseases through the suppression of B cell activity induced by metformin. More particularly, the present invention relates to a composition comprising a metformin compound or a pharmaceutically acceptable salt thereof as an active ingredient for preventing or treating immune diseases, wherein the composition is characterized by suppression or reduction of B cell activity which is a cause of disease. The present invention can be valuable in the use thereof for various autoimmune diseases as an immunosuppressant which can prevent or treat immune diseases by suppressing or reducing B cell activity and Th17 cell activity, which are causes of disease, or by promoting or increasing regulatory T cell activity.

公开(公告)号：US20150297676A1

公开(公告)日：2015-10-22

申请号：US14426324

申请日：2013-09-02

Applicant: Catholic University Industry Academic Cooperation Foundation

Inventor： Mi-La CHO ,  Joo-Yeon Jhun ,  Seon-Yeong Lee ,  Yeong-Mi Mun ,  Jun-Geol Ryu ,  Jae-Kyeong Byun ,  Hye-Jin Son ,  Eun-Kyung Kim ,  Eun-Ji Yang ,  Jeong-Hee Jeong

IPC: A61K38/17 ,  G01N33/68 ,  C07K14/47

CPC classification number: A61K38/1709 ,  A61K38/1761 ,  C07K14/47 ,  G01N33/6872 ,  G01N33/6893 ,  G01N2333/4704 ,  G01N2500/04 ,  G01N2500/10 ,  G01N2800/044

Abstract: The present invention relates to a composition comprising GRIM-19 protein as an active ingredient for preventing or treating obesity or lipid-related metabolic diseases. More particularly, the present invention relates to a composition for preventing or treating obesity or lipid-related metabolic diseases wherein the composition comprises GRIM-19 protein as an active ingredient for preventing or treating metabolic diseases caused by immune response disorders or interactions between genetic, metabolic, or environmental complex factors. The GRIM-19 protein according to the present invention exhibits excellent effectiveness not only in reducing lipocytes and total cholesterol content in the body, but also in suppressing the differentiation of cytotoxic Th17 cells that produce and secrete inflammatory cytokines. Also, GRIM-19 has been found to have excellent effectiveness in regulating a STAT3 mediated inflammatory response in an inflammatory environment related to obesity. Thus, the present invention can be used for preparing a treatment agent and a functional food that can effectively treat obesity or lipid-related metabolic diseases.

Abstract translation: 本发明涉及包含GRIM-19蛋白作为预防或治疗肥胖症或与脂质有关的代谢疾病的活性成分的组合物。 更具体地说，本发明涉及用于预防或治疗肥胖症或与脂质有关的代谢性疾病的组合物，其中组合物包含GRIM-19蛋白作为预防或治疗由免疫应答障碍引起的代谢疾病或遗传代谢之间的相互作用的活性成分 ，或环境复杂因素。 根据本发明的GRIM-19蛋白质不仅在体内减少脂肪细胞和总胆固醇含量方面表现出优异的效果，而且在抑制产生和分泌炎性细胞因子的细胞毒性Th17细胞的分化方面表现出优异的效果。 此外，已经发现GRIM-19在与肥胖相关的炎症环境中调节STAT3介导的炎症反应具有优异的有效性。 因此，本发明可用于制备能够有效治疗肥胖症或与脂质有关的代谢疾病的治疗剂和功能性食品。