专利检索 ap:("CEDARS-SINAI MEDICAL CENTER" OR "THE REGENTS OF THE UNIVERSITY OF CALIFORNIA") AND inv:"Barry R. Stripp" 第 1 页

1.

发明公开
ORGAN INFECTION MODELS 审中-公开

公开(公告)号：US20230174946A1

公开(公告)日：2023-06-08

申请号：US17922162

申请日：2021-04-30

申请人： CEDARS-SINAI MEDICAL CENTER , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Barry R. Stripp , Apoorva Mulay , Bindu Konda , Arun Sharma , Clive Svendsen , Vaithilingaraja Arumugaswami , Dhruv Sareen , Hanan Shaharuddin , Victoria Wang , Roberta S. Santos

IPC分类号： C12N5/071 , C12N5/077 , C12M3/06

CPC分类号： C12N5/0676 , C12M23/16 , C12N5/0657 , C12N5/0688 , C12N2503/02 , C12N2506/45

摘要： Described herein are particular infection model systems, methods of studying infection, and method of screening compounds in various model systems. Particularly, SARS-CoV-2 is studied in these organ and infection models.

2.

发明公开
ISOLATION AND FUNCTIONAL ANALYSIS OF EPITHELIAL PROGENITOR CELLS FROM THE HUMAN LUNG 审中-公开

公开(公告)号：US20230167413A1

公开(公告)日：2023-06-01

申请号：US17921174

申请日：2021-04-30

申请人： CEDARS-SINAI MEDICAL CENTER

发明人： Barry R. Stripp , Bindu Konda , Apoorva Mulay

IPC分类号： C12N5/071 , G01N33/50 , G01N1/30 , G01N33/569

CPC分类号： C12N5/0689 , G01N33/5044 , G01N1/30 , G01N33/56966 , C12N2513/00 , C12N2509/10 , C12N2501/727 , C12N2501/15

摘要： The in vitro organoid model is a major technological breakthrough and an essential tool to study the basic biology of an organ system and for the development of various clinical applications for disease intervention. Organoids can self-renew and exhibit similarities in function as of their tissue of origin. Here, a step-by-step protocol is described to isolate region-specific progenitors from the human lung and generate 3D organoid cultures as an experimental and validation tool.