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公开(公告)号：US20240306908A1
公开(公告)日：2024-09-19
申请号：US18577161
申请日：2022-07-08
发明人： Maya Koronyo , Yosef Koronyo , Keith L. Black , Nazanin Mirzaei , Liang Gao
摘要： The present invention describes systems and method for the detection, diagnosis and monitoring of cognitive impairment and Alzheimer's disease. In one example, an integrated system comprising a full-field Fourier domain optical coherence tomography and an image mapping spectrometry is used for generating spectrally resolved volumetric images at wavelengths that show difference in spectral signatures of normal cells compared to spectral signatures of amyloid beta and pTau deposits, and also image inner retinal layers where amyloid beta and pTau deposits may aggregate.
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公开(公告)号：US11058720B2
公开(公告)日：2021-07-13
申请号：US16303053
申请日：2017-05-22
摘要： The present invention describes a method of treating, preventing, reducing the likelihood of or alleviating a symptom of Alzheimer's disease and associated conditions by increasing OPN expression. The invention further provides for a method of improving cognitive function in a subject in need thereof.
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公开(公告)号：US10512699B2
公开(公告)日：2019-12-24
申请号：US15798612
申请日：2017-10-31
发明人： Yosef Koronyo , Maya Koronyo , Keith Black , Michal Schwartz , Daniel L. Farkas
IPC分类号： A61B5/00 , A61B3/00 , A61B6/00 , A61K49/00 , A61K31/404 , A61K31/4965 , A61K31/5377 , A61K31/496 , A61K31/437 , G01N33/50 , A61B3/10 , A61B3/14 , A61B6/03 , C07D401/14
摘要： The present subject matter relates to a non-invasive optical imaging method for monitoring early pathological events specific to Alzheimer's disease (AD), such as the development, amount and location of amyloid plaques. The ability to monitor such events provides a basis for, among other things, AD diagnosis, prognosis and assessment of potential therapies. In addition, the present subject matter introduces novel methods for treating AD and retinal ailments associated with AD. Aβ-plaque detection in living brains is extremely limited, especially at high resolution; therefore the present invention is based on studies focusing on the eyes as an alternative to brain-derived tissue that can be imaged directly, repetitively and non-invasively.
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公开(公告)号：US11779600B2
公开(公告)日：2023-10-10
申请号：US17338305
申请日：2021-06-03
CPC分类号： A61K35/15 , A61K31/7088 , A61K38/02 , A61K38/18 , A61K38/19 , A61P25/28 , A61K38/02 , A61K2300/00 , A61K38/19 , A61K2300/00 , A61K35/15 , A61K2300/00
摘要： The present invention describes a method of treating, preventing, reducing the likelihood of or alleviating a symptom of Alzheimer's disease and associated conditions by increasing OPN expression. The invention further provides for a method of improving cognitive function in a subject in need thereof.
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公开(公告)号：US11425889B2
公开(公告)日：2022-08-30
申请号：US16301585
申请日：2017-06-02
发明人： Maya Koronyo , Yosef Koronyo , Keith L. Black
摘要： Disclosed herein is a rodent and human behavioral test for evaluating visual dysfunctions associated with the retinal changes in Alzheimer disease progression. In one example, the inventors developed a maze that tests rodent's ability to identify (1) specific contrasts, (2) specific colors, (3) certain items in the visual field, and (4) other ‘non-typical’ peripheral and night vision functions associated with AD. For instance, the inventors developed a maze the tests the rodents ability to avoid certain colors or contrasts gradients. The maze may include certain rooms with specific visual markers (e.g., colors, contrasts, objects or other visual features) that also contain shock plates.
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