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公开(公告)号：US20240306908A1
公开(公告)日：2024-09-19
申请号：US18577161
申请日：2022-07-08
发明人： Maya Koronyo , Yosef Koronyo , Keith L. Black , Nazanin Mirzaei , Liang Gao
摘要： The present invention describes systems and method for the detection, diagnosis and monitoring of cognitive impairment and Alzheimer's disease. In one example, an integrated system comprising a full-field Fourier domain optical coherence tomography and an image mapping spectrometry is used for generating spectrally resolved volumetric images at wavelengths that show difference in spectral signatures of normal cells compared to spectral signatures of amyloid beta and pTau deposits, and also image inner retinal layers where amyloid beta and pTau deposits may aggregate.
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公开(公告)号：US20190321494A1
公开(公告)日：2019-10-24
申请号：US16434545
申请日：2019-06-07
摘要： Nanoconjugates that include a polymalic-based molecular scaffold with one or more imaging moiety and one or more targeting modules attached to the scaffold are provided. Methods of targeting a diseased cell or a diseased tissue in a subject by administering the nanoconjugate are described. Methods of synthesizing the nanoconjugate are also provided.
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公开(公告)号：US20190076555A1
公开(公告)日：2019-03-14
申请号：US16128888
申请日：2018-09-12
摘要： Imaging nanoagents including a polymalic acid-based molecular scaffold, a chlorotoxin peptide or a variant thereof, and at least one fluorescent moiety are provided. Methods for detecting, treating and removing a cancer in a subject by administering the imaging nanoagent are described.
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公开(公告)号：US20170340659A1
公开(公告)日：2017-11-30
申请号：US15447439
申请日：2017-03-02
发明人： Satoshi Inoue , Hui Ding , Eggehard Holler , Keith L. Black , Julia Y. Ljubimova
IPC分类号： A61K31/713 , C07K16/28 , C07K16/32 , A61K39/00
CPC分类号： A61K31/713 , A61K2039/505 , C07K16/2881 , C07K16/32
摘要： Nanobiopolymeric conjugates based on biodegradable, non-toxic and non-immunogenic poly (β-L-malic acid) PMLA covalently linked to molecular modules that include morpholino antisense oligonucleotides (AONa), an siRNA or an antibody specific for an oncogenic protein in a cancer cell, and an antibody specific for a transferrin receptor protein, are provided. Methods for treating a cancer in subject with nanobiopolymeric conjugates are described.
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公开(公告)号：US20170274085A1
公开(公告)日：2017-09-28
申请号：US15450519
申请日：2017-03-06
IPC分类号： A61K31/4188 , A61K31/425 , C07K16/28 , C07K16/30
CPC分类号： A61K47/593 , A61K31/4188 , A61K31/425 , A61K47/48061 , A61K47/48215 , A61K47/48246 , A61K47/48338 , A61K47/48384 , A61K47/48561 , A61K47/48584 , A61K47/48623 , A61K47/48669 , A61K47/48692 , A61K47/545 , A61K47/60 , A61K47/64 , A61K47/65 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6865 , A61K47/6877 , A61K47/6883 , A61K47/6889 , A61K47/6898 , C07K16/2881 , C07K16/3015 , C07K16/3053 , C07K2317/24 , C07K2317/77
摘要： The present invention relates to methods of drug delivery for the treatment of a condition or disease, such as cancer. In one embodiment, the invention provides a method of preparing a multifunctional nanoconjugate of temozolomide (TMZ) by conjugating TMZ in its hydrazide form to a polymalic acid platform. In another embodiment, the polymalic acid platform is conjugated to a monoclonal antibody to transferrin receptor, a trileucine (LLL) moiety, and/or a polyethylene glycol (PEG) moiety. The present invention relates to methods of drug delivery for the treatment of a condition or disease, such as cancer. In one embodiment, the invention provides a method of preparing a multifunctional nanoconjugate of temozolomide (TMZ) by conjugating TMZ in its hydrazide form to a polymalic acid platform. In another embodiment, the polymalic acid platform is conjugated to a monoclonal antibody to transferrin receptor, a trileucine (LLL) moiety, and/or a polyethylene glycol (PEG) moiety.
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公开(公告)号：US20170173130A1
公开(公告)日：2017-06-22
申请号：US15227552
申请日：2016-08-03
发明人： John S. Yu , Gentao Liu , Keith L. Black
IPC分类号： A61K39/00 , C12N5/0784
CPC分类号： A61K39/0011 , A61K2035/124 , A61K2039/5154 , A61K2039/545 , C12N5/0639 , C12N2501/22 , C12N2501/23 , C12N2501/2304 , C12N2501/25 , C12N2501/998 , C12N2506/11
摘要： Methods and compositions for treating cancers (e.g., neural cancers) by dendritic cell vaccination are provided herein.
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公开(公告)号：US11779600B2
公开(公告)日：2023-10-10
申请号：US17338305
申请日：2021-06-03
CPC分类号： A61K35/15 , A61K31/7088 , A61K38/02 , A61K38/18 , A61K38/19 , A61P25/28 , A61K38/02 , A61K2300/00 , A61K38/19 , A61K2300/00 , A61K35/15 , A61K2300/00
摘要： The present invention describes a method of treating, preventing, reducing the likelihood of or alleviating a symptom of Alzheimer's disease and associated conditions by increasing OPN expression. The invention further provides for a method of improving cognitive function in a subject in need thereof.
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公开(公告)号：US20210113715A1
公开(公告)日：2021-04-22
申请号：US17047638
申请日：2019-04-18
发明人： J. Manuel Perez , Leland Chung , Yi Zhang , Keith L. Black
IPC分类号： A61K49/00 , A61K49/12 , A61K49/18 , A61K31/337 , A61K31/69 , A61K31/47 , A61K31/365 , A61K45/06 , A61P35/00
摘要： The present invention provides a nanoparticle, comprising: a core, wherein the core comprises at least one iron oxide; a shell surrounding the core, wherein the shell comprises at least one polymer; and at least one targeting moiety attached to the shell, wherein the nanoparticle does not comprise boron, for use in methods for detecting and treating cancer in a subject.
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公开(公告)号：US20170112897A1
公开(公告)日：2017-04-27
申请号：US15332880
申请日：2016-10-24
发明人： Konrad Talbot , Hoau-Yan Wang , Keith L. Black
摘要： The invention provides methods for treating brain insulin resistance and/or diseases associated therewith in a subject in need thereof. The methods include providing a composition comprising a dual GLP-1 receptor/GIP receptor (GLP-1R/GIPR) agonist and administering an effective amount of the composition to the subject to treat brain insulin resistance and diseases associated therewith.
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公开(公告)号：US09623041B2
公开(公告)日：2017-04-18
申请号：US13930533
申请日：2013-06-28
发明人： Satoshi Inoue , Hui Ding , Eggehard Holler , Keith L. Black , Julia Y. Ljubimova
IPC分类号： A61K31/713 , C07K16/28 , C07K16/32 , A61K39/00
CPC分类号： A61K31/713 , A61K2039/505 , C07K16/2881 , C07K16/32
摘要： Nanobiopolymeric conjugates based on biodegradable, non-toxic and non-immunogenic poly (β-L-malic acid) PMLA covalently linked to molecular modules that include morpholino antisense oligonucleotides (AONa), an siRNA or an antibody specific for an oncogenic protein in a cancer cell, and an antibody specific for a transferrin receptor protein, are provided. Methods for treating a cancer in subject with nanobiopolymeric conjugates are described.
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