公开(公告)号：US20170173053A1

公开(公告)日：2017-06-22

申请号：US15237548

申请日：2016-08-15

Applicant: CENTRAL ADELAIDE LOCAL HEALTH NETWORK INC.

Inventor： Joanna Woodcock ,  Stuart Pitson ,  Angel Lopez

IPC: A61K31/661 ,  A61K31/133 ,  C12Q1/48 ,  A61K31/16 ,  A61K31/201 ,  A61K31/132 ,  A61K31/14

CPC classification number: A61K31/661 ,  A61K31/132 ,  A61K31/133 ,  A61K31/14 ,  A61K31/16 ,  A61K31/201 ,  C12Q1/485 ,  G01N2500/02 ,  G01N2500/20

Abstract: The present invention relates to a method of modulating cellular activity. More particularly, the present invention provides a method of modulating apoptosis by modulating protein 14-3-3 phosphorylation and, thereby, its functionality. The present invention still further extends to methods for identifying agents capable of modulating protein 14-3-3 phosphorylation. The method and molecules of the present invention are useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by unwanted cellular activity, such as unwanted cell survival.