公开(公告)号：US20170312249A1

公开(公告)日：2017-11-02

申请号：US15517755

申请日：2015-10-08

Applicant: University of South Australia ,  Central Adelaide Local Health Network Inc.

Inventor： Joanna Woodcock ,  Angel Lopez ,  Stuart Maxwell Pitson ,  Michael Susithiran Samuel ,  Carl Coolen

IPC: A61K31/395 ,  A61K45/06 ,  A61K31/452 ,  A61K31/40 ,  A61K9/06 ,  A61K47/10 ,  A61K9/00

Abstract: The present disclosure relates to modulators of 14-3-3 functionality and their use in methods and compositions for preventing and/or treating various diseases, conditions and states, such as cancer and healing of wounds. Certain embodiments of the present disclosure provide a method of preventing and/or treating a disease, condition or state in a subject associated with altered 14-3-3 protein functionality and/or which would benefit from altering 14-3-3 functionality, the method comprising administering to the subject an effective amount of an agent which inhibits dimerization of the 14-3-3 protein, thereby preventing and/or treating the disease, condition or state in the subject.

公开(公告)号：US20170173053A1

公开(公告)日：2017-06-22

申请号：US15237548

申请日：2016-08-15

Applicant: CENTRAL ADELAIDE LOCAL HEALTH NETWORK INC.

Inventor： Joanna Woodcock ,  Stuart Pitson ,  Angel Lopez

IPC: A61K31/661 ,  A61K31/133 ,  C12Q1/48 ,  A61K31/16 ,  A61K31/201 ,  A61K31/132 ,  A61K31/14

CPC classification number: A61K31/661 ,  A61K31/132 ,  A61K31/133 ,  A61K31/14 ,  A61K31/16 ,  A61K31/201 ,  C12Q1/485 ,  G01N2500/02 ,  G01N2500/20

Abstract: The present invention relates to a method of modulating cellular activity. More particularly, the present invention provides a method of modulating apoptosis by modulating protein 14-3-3 phosphorylation and, thereby, its functionality. The present invention still further extends to methods for identifying agents capable of modulating protein 14-3-3 phosphorylation. The method and molecules of the present invention are useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by unwanted cellular activity, such as unwanted cell survival.

公开(公告)号：US10583115B2

公开(公告)日：2020-03-10

申请号：US15517755

申请日：2015-10-08

Applicant: University of South Australia ,  Central Adelaide Local Health Network Inc.

Inventor： Joanna Woodcock ,  Angel Lopez ,  Stuart Maxwell Pitson ,  Michael Susithiran Samuel ,  Carl Coolen

IPC: A61K31/395 ,  A61K45/06 ,  A61K31/40 ,  A61K31/452 ,  A61K9/00 ,  A61K47/10 ,  A61K9/06

Abstract: The present disclosure relates to modulators of 14-3-3 functionality and their use in methods and compositions for preventing and/or treating various diseases, conditions and states, such as cancer and healing of wounds. Certain embodiments of the present disclosure provide a method of preventing and/or treating a disease, condition or state in a subject associated with altered 14-3-3 protein functionality and/or which would benefit from altering 14-3-3 functionality, the method comprising administering to the subject an effective amount of an agent which inhibits dimerization of the 14-3-3 protein, thereby preventing and/or treating the disease, condition or state in the subject.