Patent search ap:("CEVEC Pharmaceuticals GmbH") AND inv:"Nikola Strempel" Page 1

1.

发明授权
Use of constitutively active variants of growth factor receptors as selection markers for the generation of stable producer cell lines 有权

公开(公告)号：US12060561B2

公开(公告)日：2024-08-13

申请号：US16636622

申请日：2018-08-01

Applicant: CEVEC Pharmaceuticals GmbH

Inventor： Nicole Faust , Silke Wissing , Nikola Strempel

IPC: C07K14/705 , C07K14/71 , C07K19/00 , C12N5/07 , C12N5/071 , C12N5/10 , C12N5/16 , C12N15/09 , C12N15/113 , C12N15/62 , C12N15/63 , C12N15/85

CPC classification number: C12N15/62 , C07K14/70517 , C07K14/71 , C07K19/00 , C12N5/06 , C12N5/0625 , C12N5/10 , C12N5/16 , C12N15/09 , C12N15/1138 , C12N15/63 , C12N15/85 , C07K2319/00 , C12N2501/105

Abstract: The present invention relates to methods for the selection of a stable producer cell line expressing one or more protein(s) of interest (POIs), comprising the stable transfection of cells with a gene encoding a constitutively active variant of a growth factor receptor, respective methods for the expression of one or more POIs in such stable producer cell lines, and uses of a constitutively active variant of a growth factor receptor as selection marker in the cultivation of cells.

2.

发明申请
Use of constitutively active variants of growth factor receptors as selection markers for the generation of stable producer cell lines 审中-公开

公开(公告)号：US20200377895A1

公开(公告)日：2020-12-03

申请号：US16636622

申请日：2018-08-01

Applicant: CEVEC Pharmaceuticals GmbH

Inventor： Nicole Faust , Silke Wissing , Nikola Strempel

IPC: C12N15/62 , C12N15/85 , C07K14/71

Abstract: The present invention relates to methods for the selection of a stable producer cell line expressing one or more protein(s) of interest (POIs), comprising the stable transfection of cells with a gene encoding a constitutively active variant of a growth factor receptor, respective methods for the expression of one or more POIs in such stable producer cell lines, and uses of a constitutively active variant of a growth factor receptor as selection marker in the cultivation of cells.

3.

发明申请
Use of constitutively active variants of growth factor receptors as selection markers for the generation of stable producer cell lines 有权

公开(公告)号：US20250002923A1

公开(公告)日：2025-01-02

申请号：US18769083

申请日：2024-07-10

Applicant: CEVEC Pharmaceuticals GmbH

Inventor： Nicole Faust , Silke Wissing , Nikola Strempel

IPC: C12N15/62 , C07K14/705 , C07K14/71 , C07K19/00 , C12N5/07 , C12N5/071 , C12N5/10 , C12N5/16 , C12N15/09 , C12N15/113 , C12N15/63 , C12N15/85

Abstract: The present invention relates to methods for the selection of a stable producer cell line expressing one or more protein(s) of interest (POIs), comprising the stable transfection of cells with a gene encoding a constitutively active variant of a growth factor receptor, respective methods for the expression of one or more POIs in such stable producer cell lines, and uses of a constitutively active variant of a growth factor receptor as selection marker in the cultivation of cells.

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