公开(公告)号：US20220409600A1

公开(公告)日：2022-12-29

申请号：US17752683

申请日：2022-05-24

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Jonathan Bard ,  Matthew R. Lee ,  Longbin Liu ,  Michael Edward Prime ,  Samuel Coe

IPC: A61K31/454 ,  A61K47/54 ,  A61K31/165 ,  A61K31/427

Abstract: The present disclosure relates generally to compounds that simultaneously bind both mutant huntingtin protein (mHTT) and an ubiquitin E3 ligase and their use as therapeutic agents, for example, in treating diseases, such as neurodegenerative disorders caused by aggregation of mHTT.

公开(公告)号：US20200276176A1

公开(公告)日：2020-09-03

申请号：US16799651

申请日：2020-02-24

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Jonathan Bard ,  Matthew R. Lee ,  Longbin Liu ,  Michael Edward Prime ,  Samuel Coe

IPC: A61K31/454 ,  A61K31/427 ,  A61K31/165 ,  A61K47/54

Abstract: The present disclosure relates generally to compounds that simultaneously bind both mutant huntingtin protein (mHTT) and an ubiquitin E3 ligase and their use as therapeutic agents, for example, in treating diseases, such as neurodegenerative disorders caused by aggregation of mHTT.

公开(公告)号：US12083108B2

公开(公告)日：2024-09-10

申请号：US17752683

申请日：2022-05-24

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Jonathan Bard ,  Matthew R. Lee ,  Longbin Liu ,  Michael Edward Prime ,  Samuel Coe

IPC: A61K31/454 ,  A61K31/165 ,  A61K31/427 ,  A61K47/54

CPC classification number: A61K31/454 ,  A61K31/165 ,  A61K31/427 ,  A61K47/555

Abstract: The present disclosure relates generally to compounds that simultaneously bind both mutant huntingtin protein (mHTT) and an ubiquitin E3 ligase and their use as therapeutic agents, for example, in treating diseases, such as neurodegenerative disorders caused by aggregation of mHTT.

公开(公告)号：US20220388998A1

公开(公告)日：2022-12-08

申请号：US17621567

申请日：2020-06-26

Applicant: CHDI Foundation, Inc

Inventor： Michel C. Maillard ,  Matthew R. Lee ,  Celia Dominguez ,  Michael Barnes ,  Alan F. Haughan ,  Tammy Ladduwahetty ,  Christopher A. Luckhurst ,  Andrew J. Stott ,  Jason Tierney

IPC: C07D413/14 ,  C07D401/04 ,  C07D405/14 ,  C07D471/04 ,  C07D213/75 ,  C07D487/04 ,  C07D487/08

Abstract: Provided herein are certain inhibitors of ROCK (rho-kinases or rho-associated kinases), which are useful as medicament, for the treatment Huntington's disease in particular.