-
公开(公告)号:US11059836B2
公开(公告)日:2021-07-13
申请号:US16530594
申请日:2019-08-02
发明人: Celia Dominguez , Samuel Coe , Peter David Johnson , Michael Edward Prime , Christopher John Brown , Sébastien René Gabriel Galan , Paul Richard Giles , Jonathan Bard , Elise Luciennen Paulette Gadouleau , Thomas Martin Krülle , Daniel Clark-Frew , John Wityak , Alex Kiselyov , Sarah Hayes
IPC分类号: C07D513/04 , C07D413/14 , C07D417/04 , A61K51/04 , C07D413/12 , C07D263/57 , C07D498/04 , C07D405/14 , C07D413/04 , C07D471/04
摘要: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
-
公开(公告)号:US20210060187A1
公开(公告)日:2021-03-04
申请号:US16987277
申请日:2020-08-06
发明人: Celia Dominguez , John Wityak , Jonathan Bard , Christopher John Brown , Michael Edward Prime , Peter David Johnson , Thomas Martin Krulle , Daniel Clark-Frew , Duane Higgins , Matthew Robert Mills , Richard Waldron Marston , Samuel Coe , Samantha Brown , Sarah Hayes
IPC分类号: A61K51/04 , C07D513/04 , C07D487/04 , C07D513/14 , C07B59/00
摘要: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
-
公开(公告)号:US11344637B2
公开(公告)日:2022-05-31
申请号:US16987277
申请日:2020-08-06
发明人: Celia Dominguez , John Wityak , Jonathan Bard , Christopher John Brown , Michael Edward Prime , Peter David Johnson , Thomas Martin Krulle , Daniel Clark-Frew , Duane Higgins , Matthew Robert Mills , Richard Waldron Marston , Samuel Coe , Samantha Brown , Sarah Hayes
IPC分类号: A61K51/04 , C07D513/04 , C07D487/04 , C07D513/14 , C07B59/00
摘要: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
-
公开(公告)号:US20170283436A1
公开(公告)日:2017-10-05
申请号:US15507208
申请日:2015-08-28
申请人: Celia DOMINGUEZ , John WITYAK , Jonathan BARD , Alex KISELYOV , Christopher John BROWN , Sebastien Rene Gabriel GALAN , Michael Edward PRIME , Paul Richard GILES , Elise Luciennen Paulette GADOULEAU , Thomas Martin KRÜLLE , Daniel CLARKFREW , Peter David JOHNSON , Sabinc SCHAERTI , Steffen Kaspar GRIMM , Jan Dirk KAHMANN , Christoph SCHEICH , Samuel COE , Sarah HAYES , CHDI Foundation, Inc.
发明人: Celia Dominguez , John Wityak , Jonathan Bard , Alex Kiselyov , Christopher John Brown , Sébastien René Gabriel Galan , Michael Edward Prime , Paul Richard Giles , Elise Luciennen Paulette Gadouleau , Thomas Martin Krülle , Daniel Clark-Frew , Peter David Johnson , Samuel Coe , Sarah Hayes
IPC分类号: C07D513/04 , C07D413/04 , C07D413/14 , A61K51/04 , C07D498/04 , C07D405/14 , C07D471/04 , C07D263/57 , C07D413/12
CPC分类号: C07D513/04 , A61K51/0455 , A61K51/0459 , A61K51/0463 , C07D263/57 , C07D405/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D471/04 , C07D498/04
摘要: Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use.
-
公开(公告)号:US20220409600A1
公开(公告)日:2022-12-29
申请号:US17752683
申请日:2022-05-24
发明人: Celia Dominguez , Jonathan Bard , Matthew R. Lee , Longbin Liu , Michael Edward Prime , Samuel Coe
IPC分类号: A61K31/454 , A61K47/54 , A61K31/165 , A61K31/427
摘要: The present disclosure relates generally to compounds that simultaneously bind both mutant huntingtin protein (mHTT) and an ubiquitin E3 ligase and their use as therapeutic agents, for example, in treating diseases, such as neurodegenerative disorders caused by aggregation of mHTT.
-
公开(公告)号:US20220339302A1
公开(公告)日:2022-10-27
申请号:US17715661
申请日:2022-04-07
发明人: Longbin Liu , Celia Dominguez , Jonathan Bard , Christopher John Brown , Xuemei Chen , Daniel Clark-Frew , Matthew Robert Mills , Peter David Johnson , Elise Gadouleau
IPC分类号: A61K51/04 , A61P25/28 , C07D401/14
摘要: Provided herein are certain isoindolinone compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, compositions thereof, and methods of their use.
-
公开(公告)号:US11071793B2
公开(公告)日:2021-07-27
申请号:US15507214
申请日:2015-08-28
发明人: Celia Dominguez , John Wityak , Jonathan Bard , Christopher John Brown , Thomas Martin Krülle , Daniel Clark-Frew , Sarah Hayes
IPC分类号: A61K51/00 , A61M36/14 , A61K51/04 , C07D401/14 , C07D403/04 , C07D401/04 , C07D487/04 , C07D513/04 , C07D513/14
摘要: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
-
公开(公告)号:US10907197B2
公开(公告)日:2021-02-02
申请号:US15507217
申请日:2015-08-28
发明人: Celia Dominguez , John Wityak , Jonathan Bard , Christopher John Brown , Michael Edward Prime , Derek Alexander Weddell , Daryl Simon Walter , Paul Richard Giles , Ian James Wigginton , Malcolm George Taylor , Sébastien René Gabriel Galan , Peter David Johnson , Thomas Martin Krülle , Inaki Morao , Daniel Clark-Frew
IPC分类号: C07D253/08 , C07D401/04 , C07D473/00 , C12Q1/6823 , A61K51/04
摘要: Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use.
-
公开(公告)号:US10479802B2
公开(公告)日:2019-11-19
申请号:US15507208
申请日:2015-08-28
发明人: Celia Dominguez , Samuel Coe , Jonathan Bard , Peter David Johnson , Michael Edward Prime , Christopher John Brown , Sébastien René Gabriel Galan , Paul Richard Giles , Elise Luciennen Paulette Gadouleau , Thomas Martin Krülle , Daniel Clark-Frew , John Wityak , Alex Kiselyov , Sarah Hayes
IPC分类号: C07D513/04 , C07D413/14 , C07D471/04 , A61K51/04 , C07D413/12 , C07D263/57 , C07D498/04 , C07D405/14 , C07D413/04
摘要: Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use.
-
公开(公告)号:US20170283439A1
公开(公告)日:2017-10-05
申请号:US15507203
申请日:2015-08-28
发明人: Celia Dominguez , John Wityak , Jonathan Bard , Alex Kiselyov , Christopher John Brown , Michael Edward Prime , Peter David Johnson , Daniel CLark-Frew
IPC分类号: C07D519/00 , A61K51/04 , C07D471/04
CPC分类号: C07D519/00 , A61K51/0455 , A61K51/0459 , C07D471/04
摘要: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
-
-
-
-
-
-
-
-
-