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公开(公告)号：US20210236663A1
公开(公告)日：2021-08-05
申请号：US17125905
申请日：2020-12-17
Applicant: CHDI Foundation, Inc.
Inventor： Longbin Liu , Matthew Lee , Celia Dominguez , Peter David Johnson , Christopher John Brown , Sarah Hayes , Adrian Kotey , Matthew Robert Mills , Michael Edward Prime
IPC: A61K51/04 , C07D401/14 , C07D401/06 , C07D471/04 , C07D401/12 , C07D491/107 , C07D487/04 , C07D413/14 , C07B59/00
Abstract: Provided herein are certain compounds and imaging agents useful for detecting a condition or disorder associated with protein aggregation, compositions thereof, and methods of their use.
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公开(公告)号：US11059836B2
公开(公告)日：2021-07-13
申请号：US16530594
申请日：2019-08-02
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , Samuel Coe , Peter David Johnson , Michael Edward Prime , Christopher John Brown , Sébastien René Gabriel Galan , Paul Richard Giles , Jonathan Bard , Elise Luciennen Paulette Gadouleau , Thomas Martin Krülle , Daniel Clark-Frew , John Wityak , Alex Kiselyov , Sarah Hayes
IPC: C07D513/04 , C07D413/14 , C07D417/04 , A61K51/04 , C07D413/12 , C07D263/57 , C07D498/04 , C07D405/14 , C07D413/04 , C07D471/04
Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
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公开(公告)号：US20210060187A1
公开(公告)日：2021-03-04
申请号：US16987277
申请日：2020-08-06
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , John Wityak , Jonathan Bard , Christopher John Brown , Michael Edward Prime , Peter David Johnson , Thomas Martin Krulle , Daniel Clark-Frew , Duane Higgins , Matthew Robert Mills , Richard Waldron Marston , Samuel Coe , Samantha Brown , Sarah Hayes
IPC: A61K51/04 , C07D513/04 , C07D487/04 , C07D513/14 , C07B59/00
Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
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公开(公告)号：US12083108B2
公开(公告)日：2024-09-10
申请号：US17752683
申请日：2022-05-24
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , Jonathan Bard , Matthew R. Lee , Longbin Liu , Michael Edward Prime , Samuel Coe
IPC: A61K31/454 , A61K31/165 , A61K31/427 , A61K47/54
CPC classification number: A61K31/454 , A61K31/165 , A61K31/427 , A61K47/555
Abstract: The present disclosure relates generally to compounds that simultaneously bind both mutant huntingtin protein (mHTT) and an ubiquitin E3 ligase and their use as therapeutic agents, for example, in treating diseases, such as neurodegenerative disorders caused by aggregation of mHTT.
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公开(公告)号：US11344637B2
公开(公告)日：2022-05-31
申请号：US16987277
申请日：2020-08-06
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , John Wityak , Jonathan Bard , Christopher John Brown , Michael Edward Prime , Peter David Johnson , Thomas Martin Krulle , Daniel Clark-Frew , Duane Higgins , Matthew Robert Mills , Richard Waldron Marston , Samuel Coe , Samantha Brown , Sarah Hayes
IPC: A61K51/04 , C07D513/04 , C07D487/04 , C07D513/14 , C07B59/00
Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
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Patent Agency Ranking
公开(公告)号：US20170283436A1
公开(公告)日：2017-10-05
申请号：US15507208
申请日：2015-08-28
Applicant: Celia DOMINGUEZ , John WITYAK , Jonathan BARD , Alex KISELYOV , Christopher John BROWN , Sebastien Rene Gabriel GALAN , Michael Edward PRIME , Paul Richard GILES , Elise Luciennen Paulette GADOULEAU , Thomas Martin KRÜLLE , Daniel CLARKFREW , Peter David JOHNSON , Sabinc SCHAERTI , Steffen Kaspar GRIMM , Jan Dirk KAHMANN , Christoph SCHEICH , Samuel COE , Sarah HAYES , CHDI Foundation, Inc.
Inventor： Celia Dominguez , John Wityak , Jonathan Bard , Alex Kiselyov , Christopher John Brown , Sébastien René Gabriel Galan , Michael Edward Prime , Paul Richard Giles , Elise Luciennen Paulette Gadouleau , Thomas Martin Krülle , Daniel Clark-Frew , Peter David Johnson , Samuel Coe , Sarah Hayes
IPC: C07D513/04 , C07D413/04 , C07D413/14 , A61K51/04 , C07D498/04 , C07D405/14 , C07D471/04 , C07D263/57 , C07D413/12
CPC classification number: C07D513/04 , A61K51/0455 , A61K51/0459 , A61K51/0463 , C07D263/57 , C07D405/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D471/04 , C07D498/04
Abstract: Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use.
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公开(公告)号：US12258355B2
公开(公告)日：2025-03-25
申请号：US17881895
申请日：2022-08-05
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , Samuel Coe , Peter David Johnson , Michael Edward Prime , Christopher John Brown , Sébastien René Gabriel Galan , Paul Richard Giles , Jonathan Bard , Elise Lucienne Paulette Gadouleau , Thomas Martin Krülle , Daniel Clark-Frew , John Wityak , Alex Kiselyov , Sarah Hayes
IPC: C07D513/04 , A61B5/00 , A61B6/03 , A61K51/04 , C07D263/57 , C07D405/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D471/04 , C07D498/04
Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
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公开(公告)号：US20220409600A1
公开(公告)日：2022-12-29
申请号：US17752683
申请日：2022-05-24
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , Jonathan Bard , Matthew R. Lee , Longbin Liu , Michael Edward Prime , Samuel Coe
IPC: A61K31/454 , A61K47/54 , A61K31/165 , A61K31/427
Abstract: The present disclosure relates generally to compounds that simultaneously bind both mutant huntingtin protein (mHTT) and an ubiquitin E3 ligase and their use as therapeutic agents, for example, in treating diseases, such as neurodegenerative disorders caused by aggregation of mHTT.
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公开(公告)号：US10907197B2
公开(公告)日：2021-02-02
申请号：US15507217
申请日：2015-08-28
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , John Wityak , Jonathan Bard , Christopher John Brown , Michael Edward Prime , Derek Alexander Weddell , Daryl Simon Walter , Paul Richard Giles , Ian James Wigginton , Malcolm George Taylor , Sébastien René Gabriel Galan , Peter David Johnson , Thomas Martin Krülle , Inaki Morao , Daniel Clark-Frew
IPC: C07D253/08 , C07D401/04 , C07D473/00 , C12Q1/6823 , A61K51/04
Abstract: Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use.
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公开(公告)号：US10479802B2
公开(公告)日：2019-11-19
申请号：US15507208
申请日：2015-08-28
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , Samuel Coe , Jonathan Bard , Peter David Johnson , Michael Edward Prime , Christopher John Brown , Sébastien René Gabriel Galan , Paul Richard Giles , Elise Luciennen Paulette Gadouleau , Thomas Martin Krülle , Daniel Clark-Frew , John Wityak , Alex Kiselyov , Sarah Hayes
IPC: C07D513/04 , C07D413/14 , C07D471/04 , A61K51/04 , C07D413/12 , C07D263/57 , C07D498/04 , C07D405/14 , C07D413/04
Abstract: Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use.
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