公开(公告)号：US20210130347A1

公开(公告)日：2021-05-06

申请号：US17071056

申请日：2020-10-15

申请人： CHEMOCENTRYX, INC.

发明人： Pingchen FAN ,  Christopher W. LANGE ,  Rebecca M. LUI ,  Darren J. McMURTRIE ,  Ryan J. SCAMP ,  Ju YANG ,  Yibin ZENG ,  Penglie ZHANG

IPC分类号： C07D471/04

摘要： Compounds are provided that are useful as immunomodulators. The compounds have the Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R2a, R2b, R3, R3a, R4, R6, R7, R8, A, Z, X1 and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US20210130325A1

公开(公告)日：2021-05-06

申请号：US17071077

申请日：2020-10-15

申请人： CHEMOCENTRYX, INC.

发明人： Pingchen FAN ,  Christopher W. LANGE ,  Rebecca M. LUI ,  Darren J. McMURTRIE ,  Ryan J. SCAMP ,  Ju YANG ,  Yibin ZENG ,  Penglie ZHANG

IPC分类号： C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D401/12 ,  C07D487/10

摘要： Compounds are provided that are useful as immunomodulators. The compounds have the Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R2a, R2b, R3, R3a, R4, R6, R7, R8, A, Z, X1 and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US20230151002A1

公开(公告)日：2023-05-18

申请号：US17735283

申请日：2022-05-03

申请人： CHEMOCENTRYX, INC.

发明人： Pingchen FAN ,  Christopher W. LANGE ,  Rebecca M. LUI ,  Viengkham MALATHONG ,  Venkat Reddy MALI ,  Sreenivas PUNNA ,  Rajinder SINGH ,  Hiroko TANAKA ,  Yibin ZENG ,  Penglie ZHANG

IPC分类号： C07D471/04 ,  A61P37/02 ,  C07D519/00

CPC分类号： C07D471/04 ,  A61P37/02 ,  C07D519/00

摘要： The present disclosure provides, inter alia, Compounds of Formula (I)





or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.

公开(公告)号：US20230115912A1

公开(公告)日：2023-04-13

申请号：US17931801

申请日：2022-09-13

申请人： CHEMOCENTRYX, INC.

发明人： Pingchen FAN ,  Christopher W. LANGE ,  Viengkham MALATHONG ,  Venkat Reddy MALI ,  Sreenivas PUNNA ,  Hiroko TANAKA ,  Yibin ZENG ,  Penglie ZHANG

IPC分类号： A61K31/437 ,  A61P37/00 ,  A61P35/00 ,  A61P9/00

摘要： The present disclosure provides, inter alia, Compounds of Formula (I) or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.

公开(公告)号：US20220127272A1

公开(公告)日：2022-04-28

申请号：US17331750

申请日：2021-05-27

申请人： CHEMOCENTRYX, INC.

发明人： Junfa FAN ,  Antoni KRASINSKI ,  Christopher W. LANGE ,  Rebecca M. LUI ,  Jeffrey P. McMAHON ,  Jay P. POWERS ,  Yibin ZENG ,  Penglie ZHANG

IPC分类号： C07D487/04 ,  A61K51/04 ,  G01N33/574

摘要： Compounds having formula I, or pharmaceutically acceptable salts, hydrates or N-oxides thereof are provided and are useful for binding to CXCR7, and treating diseases that are dependent, at least in part, on CXCR7 activity. Accordingly, the present invention provides in further aspects, compositions containing one or more of the above-noted compounds in admixture with a pharmaceutically acceptable excipient.

公开(公告)号：US20210009594A1

公开(公告)日：2021-01-14

申请号：US16865648

申请日：2020-05-04

申请人： CHEMOCENTRYX, INC.

发明人： Pingchen FAN ,  Christopher W. LANGE ,  Rebecca M. LUI ,  Viengkham MALATHONG ,  Venkat Reddy MALI ,  Sreenivas PUNNA ,  Yibin ZENG ,  Penglie ZHANG

IPC分类号： C07D487/04 ,  A61P37/02

摘要： The present disclosure provides, inter alia, Compounds of Formula (I) or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.

公开(公告)号：US20200095251A1

公开(公告)日：2020-03-26

申请号：US16379599

申请日：2019-04-09

申请人： CHEMOCENTRYX, INC.

发明人： Junfa FAN ,  Antoni KRASINSKI ,  Christopher W. LANGE ,  Rebecca M. LUI ,  Jeffrey P. McMAHON ,  Jay P. POWERS ,  Yibin ZENG ,  Penglie ZHANG

IPC分类号： C07D487/04 ,  G01N33/574 ,  A61K51/04

摘要： Compounds having formula I, or pharmaceutically acceptable salts, hydrates or N-oxides thereof are provided and are useful for binding to CXCR7, and treating diseases that are dependent, at least in part, on CXCR7 activity. Accordingly, the present invention provides in further aspects, compositions containing one or more of the above-noted compounds in admixture with a pharmaceutically acceptable excipient.

公开(公告)号：US20190194208A1

公开(公告)日：2019-06-27

申请号：US16226898

申请日：2018-12-20

申请人： CHEMOCENTRYX, INC.

发明人： Pingchen FAN ,  Christopher W. LANGE ,  Rebecca M. LUI ,  Viengkham MALATHONG ,  Venkat Reddy MALI ,  Sreenivas PUNNA ,  Rajinder SINGH ,  Yibin ZENG ,  Penglie ZHANG

IPC分类号： C07D487/04 ,  A61K9/00 ,  A61K45/06 ,  A61K31/4162 ,  A61P7/00 ,  A61P19/02 ,  A61P11/00 ,  A61P25/28 ,  A61P37/06 ,  A61P35/00

摘要： The present disclosure provides, inter alia, Compounds of Formula (I) or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.

公开(公告)号：US20190192491A1

公开(公告)日：2019-06-27

申请号：US16226865

申请日：2018-12-20

申请人： CHEMOCENTRYX, INC.

发明人： Pingchen FAN ,  Christopher W. LANGE ,  Viengkham MALATHONG ,  Venkat Reddy MALI ,  Sreenivas PUNNA ,  Hiroko TANAKA ,  Yibin ZENG ,  Penglie ZHANG

IPC分类号： A61K31/437 ,  A61P37/00 ,  A61P9/00 ,  A61P35/00

摘要： The present disclosure provides, inter alia, Compounds of Formula (I) or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.

公开(公告)号：US20230133406A1

公开(公告)日：2023-05-04

申请号：US17820271

申请日：2022-08-17

申请人： CHEMOCENTRYX, INC.

发明人： Penglie ZHANG ,  Daniel R. MARSHALL ,  Howard S. ROTH ,  Aubrie HARLAND ,  Ju YANG ,  Christopher W. LANGE ,  Rebecca M. LUI ,  Antoni KRASINSKI

IPC分类号： C07D401/14 ,  C07D413/14 ,  C07D471/04 ,  C07D417/14 ,  C07D491/107 ,  C07D487/10 ,  C07D401/12 ,  C07D491/20

摘要： Compounds of formula (A) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6: