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公开(公告)号：US20220127272A1
公开(公告)日：2022-04-28
申请号：US17331750
申请日：2021-05-27
申请人： CHEMOCENTRYX, INC.
发明人： Junfa FAN , Antoni KRASINSKI , Christopher W. LANGE , Rebecca M. LUI , Jeffrey P. McMAHON , Jay P. POWERS , Yibin ZENG , Penglie ZHANG
IPC分类号： C07D487/04 , A61K51/04 , G01N33/574
摘要： Compounds having formula I, or pharmaceutically acceptable salts, hydrates or N-oxides thereof are provided and are useful for binding to CXCR7, and treating diseases that are dependent, at least in part, on CXCR7 activity. Accordingly, the present invention provides in further aspects, compositions containing one or more of the above-noted compounds in admixture with a pharmaceutically acceptable excipient.
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公开(公告)号：US20200095251A1
公开(公告)日：2020-03-26
申请号：US16379599
申请日：2019-04-09
申请人： CHEMOCENTRYX, INC.
发明人： Junfa FAN , Antoni KRASINSKI , Christopher W. LANGE , Rebecca M. LUI , Jeffrey P. McMAHON , Jay P. POWERS , Yibin ZENG , Penglie ZHANG
IPC分类号： C07D487/04 , G01N33/574 , A61K51/04
摘要： Compounds having formula I, or pharmaceutically acceptable salts, hydrates or N-oxides thereof are provided and are useful for binding to CXCR7, and treating diseases that are dependent, at least in part, on CXCR7 activity. Accordingly, the present invention provides in further aspects, compositions containing one or more of the above-noted compounds in admixture with a pharmaceutically acceptable excipient.
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公开(公告)号：US20220194929A1
公开(公告)日：2022-06-23
申请号：US17470464
申请日：2021-09-09
申请人： CHEMOCENTRYX, INC.
发明人： Trevor T. CHARVAT , Junfa FAN , Christopher W. LANGE , Manmohan Reddy LELETI , Yandong LI , Venkat Reddy MALI , Jeffrey P. McMAHON , Jay POWERS , Sreenivas PUNNA , Ju YANG
IPC分类号： C07D413/06 , C07D401/04 , C07D403/06 , C07D405/06 , C07D417/04 , C07D211/56 , C07D295/135 , C07D211/62 , C07D401/06 , C07D211/26 , C07D211/70 , C07D241/04 , C07D207/16 , C07D211/34 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/495 , A61K31/496 , A61K31/5377
摘要： Aniline compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.
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公开(公告)号：US20220153733A1
公开(公告)日：2022-05-19
申请号：US17357427
申请日：2021-06-24
申请人： CHEMOCENTRYX, INC.
发明人： Junfa FAN , Jaroslaw KALISIAK , Rebecca M. LUI , Venkat Reddy MALI , Jeffrey P. McMAHON , Jay P. POWERS , Hiroko TANAKA , Yibin ZENG , Penglie ZHANG
IPC分类号： C07D471/04 , A61K31/4545 , C07D405/04 , A61K31/453 , A61K31/496 , C07D413/14 , A61K31/536 , C07D405/14 , A61K31/4725 , A61P37/00 , A61P35/00 , A61K45/06 , A61K31/538 , A61K31/551 , A61K31/553
摘要： Compounds are provided that are modulators of the CCR2 receptor. The compounds have the general formula (Ia1′): and are useful in pharmaceutical compositions, methods or the treatment of diseases and disorders involving the pathologic activation of CCR2 receptors.
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公开(公告)号：US20180086756A1
公开(公告)日：2018-03-29
申请号：US15692811
申请日：2017-08-31
申请人： CHEMOCENTRYX, INC.
发明人： Junfa FAN , Jaroslaw KALISIAK , Rebecca M. LUI , Venkat Reddy MALI , Jeffrey P. McMAHON , Jay P. POWERS , Hiroko TANAKA , Yibin ZENG , Penglie ZHANG
IPC分类号： C07D471/04 , A61K31/4725 , C07D405/14 , A61K31/536 , C07D413/14 , A61K31/453 , C07D405/04 , A61K31/4545 , A61K31/496
CPC分类号： C07D471/04 , A61K31/453 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/536 , A61K45/06 , A61P35/00 , A61P37/00 , C07D405/04 , C07D405/14 , C07D413/14
摘要： Compounds are provided that are modulators of the CCR2 receptor. The compounds have the general formula (I): and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of CCR2 receptors.
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公开(公告)号：US20150073017A1
公开(公告)日：2015-03-12
申请号：US14541637
申请日：2014-11-14
申请人： ChemoCentryx, Inc.
发明人： Xi CHEN , Junfa FAN , Pingchen FAN , Antoni KRASINSKI , Lianfa LI , Rebecca M. LUI , Jeffrey P. McMAHON , Jay P. POWERS , Yibin ZENG , Penglie ZHANG
IPC分类号： A61K31/4709
CPC分类号： A61K31/4709 , A61K31/415 , A61K31/4725 , A61K31/502 , A61K31/517 , A61K31/5377 , A61K45/06 , C07D231/42 , C07D401/04 , C07D401/06 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/14
摘要： Compounds are provided that act as potent antagonists of the CCR(9) receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR(9). The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR(9)-mediated diseases, and as controls in assays for the identification of CCR(9) antagonists.
摘要翻译： 提供了作为CCR（9）受体的有效拮抗剂的化合物。 动物实验表明，这些化合物可用于治疗炎症，CCR的标志性疾病（9）。 化合物通常为芳基磺酰胺衍生物，并且可用于药物组合物，用于治疗CCR（9）介导的疾病的方法，以及用于鉴定CCR（9）拮抗剂的测定中的对照。
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公开(公告)号：US20130225580A1
公开(公告)日：2013-08-29
申请号：US13781412
申请日：2013-02-28
申请人： ChemoCentryx, Inc.
发明人： Xi CHEN , Junfa FAN , Pingchen FAN , Antoni KRASINSKI , Lianfa LI , Rebecca M. LUI , Jeffrey P. McMAHON , Jay P. POWERS , Yibin ZENG , Penglie ZHANG
IPC分类号： C07D405/14 , A61K31/4709 , A61K45/06 , C07D403/10 , A61K31/4725 , C07D231/42 , A61K31/415 , A61K31/502 , A61K31/5377 , C07D401/04 , C07D401/10 , A61K31/517
CPC分类号： A61K31/4709 , A61K31/415 , A61K31/4725 , A61K31/502 , A61K31/517 , A61K31/5377 , A61K45/06 , C07D231/42 , C07D401/04 , C07D401/06 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/14
摘要： Compounds are provided that act as potent antagonists of the CCR(9) receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR(9). The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR(9)-mediated diseases, and as controls in assays for the identification of CCR(9) antagonists.
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公开(公告)号：US20190060304A1
公开(公告)日：2019-02-28
申请号：US16170752
申请日：2018-10-25
申请人： ChemoCentryx, Inc.
发明人： Xi CHEN , Junfa FAN , Pingchen FAN , Antoni KRASINSKI , Lianfa LI , Rebecca M. LUI , Jeffrey P. McMAHON , Jay P. POWERS , Yibin ZENG , Penglie ZHANG
IPC分类号： A61K31/4709 , C07D401/04 , C07D231/42 , A61K31/5377 , A61K31/502 , C07D405/14 , C07D403/04 , A61K31/415 , A61K31/517 , C07D401/10 , C07D403/10 , A61K45/06 , C07D401/06 , A61K31/4725
摘要： Compounds are provided that act as potent antagonists of the CCR(9) receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR(9). The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR(9)-mediated diseases, and as controls in assays for the identification of CCR(9) antagonists.
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公开(公告)号：US20180162846A1
公开(公告)日：2018-06-14
申请号：US15674230
申请日：2017-08-10
申请人： CHEMOCENTRYX, INC.
发明人： Trevor T. CHARVAT , Junfa FAN , Christopher W. LANGE , Manmohan Reddy LELETI , Yandong LI , Venkat Reddy MALI , Jeffrey P. McMAHON , Jay POWERS , Sreenivas PUNNA , Ju YANG
IPC分类号： C07D413/06 , A61K31/5377 , C07D401/04 , A61K31/495 , A61K31/4545 , A61K31/454 , A61K31/451 , C07D211/34 , C07D207/16 , C07D241/04 , C07D211/70 , C07D211/26 , C07D211/62 , C07D295/135 , C07D211/56 , C07D417/04 , C07D405/06 , C07D403/06 , C07D401/06 , A61K31/496
CPC分类号： C07D413/06 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/495 , A61K31/496 , A61K31/5377 , C07D207/16 , C07D211/26 , C07D211/34 , C07D211/56 , C07D211/62 , C07D211/70 , C07D241/04 , C07D295/135 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/06 , C07D417/04
摘要： Aniline compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.
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公开(公告)号：US20180086766A1
公开(公告)日：2018-03-29
申请号：US15692739
申请日：2017-08-31
申请人： CHEMOCENTRYX, INC.
发明人： Junfa FAN , Antoni KRASINSKI , Christopher W. LANGE , Rebecca M. LUI , Jeffrey P. McMAHON , Jay P. POWERS , Yibin ZENG , Penglie ZHANG
IPC分类号： C07D487/04 , G01N33/574 , A61K51/04
CPC分类号： C07D487/04 , A61K51/0459 , G01N33/57492 , G01N2333/7158
摘要： Compounds having formula I, or pharmaceutically acceptable salts, hydrates or N-oxides thereof are provided and are useful for binding to CXCR7, and treating diseases that are dependent, at least in part, on CXCR7 activity. Accordingly, the present invention provides in further aspects, compositions containing one or more of the above-noted compounds in admixture with a pharmaceutically acceptable excipient.
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