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公开(公告)号：US11590074B2
公开(公告)日：2023-02-28
申请号：US17019740
申请日：2020-09-14
IPC分类号： A61K9/00 , A61K31/167 , A61K31/40 , A61K31/573 , A61K45/06 , A61P11/00 , A61K47/06 , A61K47/10 , B65B31/06 , B65B31/10
摘要： Stable aerosol solution formulations comprising glycopyrronium bromide are useful for administration to patients with COPD and other respiratory conditions.
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公开(公告)号：US10806701B2
公开(公告)日：2020-10-20
申请号：US14791553
申请日：2015-07-06
IPC分类号： A61K9/00 , A61K31/167 , A61K31/40 , A61K45/06 , A61K47/06 , A61K31/573 , A61K47/10 , B65B31/06 , B65B31/10
摘要： Stable aerosol solution formulations comprising glycopyrronium bromide are useful for administration to patients with COPD and other respiratory conditions.
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3.发明授权公开(公告)号：US10596149B2
公开(公告)日：2020-03-24
申请号：US15379924
申请日：2016-12-15
发明人： Sauro Bonelli , Diego Copelli , Massimiliano Dagli Alberi , Francesca Usberti , Enrico Zambelli
IPC分类号： A61K31/40 , A61K9/12 , A61K9/00 , A61K31/167 , A61K47/10 , A61K31/573 , A61K47/06 , A61M15/00 , B65D83/14 , A61K47/02 , B65D83/54 , A61K31/58 , A61K45/06 , A61M39/22 , A61K47/08
摘要： Aerosol solution compositions intended for use with a pressurized metered dose inhaler, comprising glycopyrronium bromide and formoterol, or a salt thereof, optionally in combination with one or more additional active ingredients, and stabilized by a selected amount of a mineral acid, exhibit improved stability when contained in an aerosol can provided with a metering valve having at least a butyl rubber gasket.
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4.发明授权公开(公告)号：US10596113B2
公开(公告)日：2020-03-24
申请号：US14585533
申请日：2014-12-30
发明人： Sauro Bonelli , Diego Copelli , Massimiliano Dagli Alberi , Francesca Usberti , Enrico Zambelli
IPC分类号： A61K31/40 , A61K9/12 , A61K9/00 , A61K31/167 , A61K47/10 , A61M15/00 , A61K31/573 , A61K31/58 , A61K45/06 , A61M39/22
摘要： Aerosol solution compositions intended for use with a pressurized metered dose inhaler, comprising glycopyrronium bromide and formoterol, or a salt thereof or a solvate of said salt, optionally in combination with one or more additional active ingredients, and stabilized by a selected amount of a mineral acid, exhibit improved stability when contained in a can internally coated by a resin comprising a fluorinated ethylene propylene (FEP) polymer.
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公开(公告)号：US20210000738A1
公开(公告)日：2021-01-07
申请号：US17019740
申请日：2020-09-14
IPC分类号： A61K9/00 , A61K31/40 , A61K45/06 , A61K31/167 , A61K31/573 , A61K47/06 , A61K47/10 , B65B31/06 , B65B31/10
摘要： Stable aerosol solution formulations comprising glycopyrronium bromide are useful for administration to patients with COPD and other respiratory conditions.
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公开(公告)号：US10159645B2
公开(公告)日：2018-12-25
申请号：US14812190
申请日：2015-07-29
IPC分类号： A61K9/00 , A61K31/573 , A61K31/16 , A61K9/12 , A61K31/40 , A61K45/06 , B65B31/00 , B65B7/28 , B65B3/04 , A61K31/167
摘要： Aerosol formulations comprising glycopyrronium bromide in combination with formoterol are useful for the prevention or treatment of chronic obstructive pulmonary disease. The formulation further comprises a HFA propellant, a co-solvent, and an amount of inorganic acid sufficient to stabilize both the glycopyrronium bromide and the formoterol components. Optionally the formulation may further comprise beclometasone dipropionate.
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公开(公告)号：US20180021301A1
公开(公告)日：2018-01-25
申请号：US15697791
申请日：2017-09-07
摘要： The stable aerosol solution formulations comprising glycopyrronium chloride are useful for administration to patients with COPD and other respiratory conditions.
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