公开(公告)号：US20160326147A1

公开(公告)日：2016-11-10

申请号：US15148225

申请日：2016-05-06

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Elisabetta ARMANI ,  Gabriele AMARI ,  Wesley BLACKABY ,  Herve VAN DE POEL ,  Charles BAKER-GLENN ,  Naimisha TRIVEDI

IPC: C07D409/12 ,  C07D409/14 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/4545 ,  C07D453/02 ,  A61K31/439

CPC classification number: C07D409/12 ,  A61K31/439 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/4545 ,  C07D409/14 ,  C07D453/02 ,  C07D471/08

Abstract: Compounds of formula (I) are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction.

Abstract translation: 式（I）化合物既是磷酸二酯酶4（PDE4）酶抑制剂和毒蕈碱M3受体拮抗剂，也可用于预防和/或治疗以气道阻塞为特征的呼吸道疾病。

公开(公告)号：US20150352091A1

公开(公告)日：2015-12-10

申请号：US14723964

申请日：2015-05-28

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Elisabetta ARMANI ,  Gabriele AMARI ,  Carmelida CAPALDI ,  Wesley BLACKABY ,  Ian LINNEY ,  Hervé VAN DE POËL ,  Charles BAKER-GLENN ,  Naimisha TRIVEDI

IPC: A61K31/444 ,  A61K31/4436 ,  C07D409/12 ,  A61K31/4545 ,  C07D453/02 ,  C07D409/14

CPC classification number: A61K31/444 ,  A61K31/4436 ,  A61K31/4545 ,  C07D409/12 ,  C07D409/14 ,  C07D453/02

Abstract: Compounds of formula (I), defined herein, are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of a disease of the respiratory tract.

Abstract translation: 式（I）化合物（本文定义）均为磷酸二酯酶4（PDE4）酶抑制剂和毒蕈碱M3受体拮抗剂，可用于预防和/或治疗呼吸道疾病。

公开(公告)号：US20170152256A1

公开(公告)日：2017-06-01

申请号：US15316401

申请日：2014-06-04

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Gabriele AMARI ,  Elisabetta ARMANI ,  Mauro RICCABONI ,  Andrea RIZZI ,  Charles BAKER-GLENN ,  Wesley BLACKABY ,  Herve VAN DE POEL ,  Ben WHITTAKER

IPC: C07D453/02

CPC classification number: C07D453/02 ,  C07D453/00

Abstract: The invention relates to novel 3,5-dichloro,4-(3,4-(cyclo-) alkoxyphenyl)-2-carbonyloxy)ethyl)pyridine compounds which are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.