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公开(公告)号：US20230092892A1
公开(公告)日：2023-03-23
申请号：US17615056
申请日：2020-05-28
发明人： Paolo BRUNO , Matteo BIAGETTI , Claudio FIORELLI , Daniela PIZZIRANI , Daniele PALA , Paolo RONCHI , Charles BAKER-GLENN , Hervè VAN DE POËL , Kim Louise HIRST
IPC分类号： C07D403/12 , C07D401/12 , C07D487/04 , C07D417/14 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/12 , C07D413/12 , C07D239/94 , C07D409/14 , C07D409/12
摘要： The present invention relates to compounds of formula I inhibiting P2X purinoceptor 3; particularly the invention relates to compounds that are amino quinazoline derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of many disorders associated with P2X3 receptors mechanisms, such as respiratory diseases including cough, asthma, idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).
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公开(公告)号：US20220235060A1
公开(公告)日：2022-07-28
申请号：US17615012
申请日：2020-05-28
发明人： Paolo BRUNO , Matteo BIAGETTI , Claudio FIORELLI , Charles BAKER-GLENN , Hervè VAN DE POËL , Stephen David PENROSE , Roberta LANARO
IPC分类号： C07D487/04 , C07D471/04
摘要： The present invention relates to compounds of formula I inhibiting P2X purinoceptor 3 (hereinafter P2X3 inhibitors); particularly the invention relates to compounds that are pyridopyrimidines derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of many disorders associated with P2X3 receptors mechanisms, such as respiratory diseases including cough, asthma, idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).
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公开(公告)号：US20150352091A1
公开(公告)日：2015-12-10
申请号：US14723964
申请日：2015-05-28
发明人： Elisabetta ARMANI , Gabriele AMARI , Carmelida CAPALDI , Wesley BLACKABY , Ian LINNEY , Hervé VAN DE POËL , Charles BAKER-GLENN , Naimisha TRIVEDI
IPC分类号： A61K31/444 , A61K31/4436 , C07D409/12 , A61K31/4545 , C07D453/02 , C07D409/14
CPC分类号： A61K31/444 , A61K31/4436 , A61K31/4545 , C07D409/12 , C07D409/14 , C07D453/02
摘要： Compounds of formula (I), defined herein, are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of a disease of the respiratory tract.
摘要翻译： 式（I）化合物（本文定义）均为磷酸二酯酶4（PDE4）酶抑制剂和毒蕈碱M3受体拮抗剂，可用于预防和/或治疗呼吸道疾病。
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公开(公告)号：US20240025880A1
公开(公告)日：2024-01-25
申请号：US18038744
申请日：2021-11-26
发明人： Claudio FIORELLI , Paolo BRUNO , Matteo BIAGETTI , Daniela PIZZIRANI , Daniele PALA , Paolo RONCHI , Sara GUARIENTO , Charles BAKER-GLENN , Hervé VAN DE POËL , Kim Louise HIRST
IPC分类号： C07D403/12 , C07D401/14 , C07D419/00 , C07D403/14 , C07D417/12 , C07D413/14 , C07D413/12 , C07D405/14
CPC分类号： C07D403/12 , C07D401/14 , C07D419/00 , C07D403/14 , C07D417/12 , C07D413/14 , C07D413/12 , C07D405/14
摘要： The present invention relates to compounds of formula I inhibiting P2X purinoceptor 3; particularly the invention relates to compounds that are amino quinazoline derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of many disorders associated with P2X3 receptors mechanisms, such as respiratory diseases including cough, asthma, idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).
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公开(公告)号：US20230212169A9
公开(公告)日：2023-07-06
申请号：US17615012
申请日：2020-05-28
发明人： Paolo BRUNO , Matteo BIAGETTI , Claudio FIORELLI , Charles BAKER-GLENN , Hervè VAN DE POËL , Stephen David PENROSE , Roberta LANARO
IPC分类号： C07D487/04 , C07D471/04
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention relates to compounds of formula I inhibiting P2X purinoceptor 3 (hereinafter P2X3 inhibitors); particularly the invention relates to compounds that are pyridopyrimidines derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of many disorders associated with P2X3 receptors mechanisms, such as respiratory diseases including cough, asthma, idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).
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公开(公告)号：US20170145004A1
公开(公告)日：2017-05-25
申请号：US15316312
申请日：2014-06-04
IPC分类号： C07D453/02 , A61K9/00 , A61K31/444
CPC分类号： C07D453/02 , A61K9/0073 , A61K31/444 , C07D453/00
摘要： The invention relates to novel 3,5-dichloro,4-(3,4-(cyclo-) alkoxyphenyl)-2-carbonyloxy)ethyl)pyridine compounds which are both inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.
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7.发明申请公开(公告)号：US20170152256A1
公开(公告)日：2017-06-01
申请号：US15316401
申请日：2014-06-04
发明人： Gabriele AMARI , Elisabetta ARMANI , Mauro RICCABONI , Andrea RIZZI , Charles BAKER-GLENN , Wesley BLACKABY , Herve VAN DE POEL , Ben WHITTAKER
IPC分类号： C07D453/02
CPC分类号： C07D453/02 , C07D453/00
摘要： The invention relates to novel 3,5-dichloro,4-(3,4-(cyclo-) alkoxyphenyl)-2-carbonyloxy)ethyl)pyridine compounds which are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.
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公开(公告)号：US20160346260A1
公开(公告)日：2016-12-01
申请号：US15168438
申请日：2016-05-31
发明人： Gabriele AMARI , Elisabetta ARMANI , Herve VAN DE POEOL , Charles BAKER-GLENN , Naimisha TRIVEDI
IPC分类号： A61K31/444 , A61K31/452 , C07D453/02 , C07D401/12
CPC分类号： A61K31/444 , A61K31/452 , C07D401/12 , C07D453/02
摘要： Compounds of formula (I) defined herein are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for treating diseases of the respiratory tract.
摘要翻译： 本文定义的式（I）化合物均为磷酸二酯酶4（PDE4）酶抑制剂和毒蕈碱M3受体拮抗剂，可用于治疗呼吸道疾病。
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公开(公告)号：US20150158858A1
公开(公告)日：2015-06-11
申请号：US14560140
申请日：2014-12-04
发明人： Gabriele AMARI , Elisabetta ARMANI , Eleonora GHIDINI , Charles BAKER-GLENN , Hervé VAN DE POËL , Ben WHITTAKER
IPC分类号： C07D453/02 , C07D409/14 , A61M15/00 , A61K31/4545 , A61K31/4436 , A61M16/14 , A61K31/444 , A61K31/4439
CPC分类号： C07D453/02 , A61K31/44 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61M15/0065 , A61M16/14 , A61M2202/064 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Compounds of formula (I) described herein are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction.
摘要翻译： 本文所述的式（I）化合物既是磷酸二酯酶4（PDE4）酶抑制剂和毒蕈碱M3受体拮抗剂，并且可用于预防和/或治疗以气道阻塞为特征的呼吸道疾病。
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公开(公告)号：US20240002371A1
公开(公告)日：2024-01-04
申请号：US18038802
申请日：2021-11-26
IPC分类号： C07D405/14 , C07D237/34 , C07D403/12 , C07D417/14
CPC分类号： C07D405/14 , C07D237/34 , C07D403/12 , C07D417/14
摘要： The present invention relates to compounds of formula (I) inhibiting P2X purinoceptor 3; particularly the invention relates to compounds that are phthalazine derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of many disorders associated with P2X3 receptors mechanisms, such as respiratory diseases including cough, asthma, idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).
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