公开(公告)号：US20240216507A1

公开(公告)日：2024-07-04

申请号：US17907180

申请日：2021-03-22

申请人： CHILDREN'S NATIONAL MEDICAL CENTER

发明人： Catherine BOLLARD ,  Michael KELLER ,  Chris LAZARSKI ,  Allistair ABRAHAM ,  Patrick HANLEY ,  Conrad Russell Y. CRUZ

IPC分类号： A61K39/00 ,  C12N5/0783

CPC分类号： A61K39/4611 ,  A61K39/464838 ,  C12N5/0636 ,  C12N2501/2304 ,  C12N2501/2307

摘要： The invention pertains to a method for preventing or treating SARS-CoV-2 infection by administering SARS-CoV-2 specific T cells which recognize particular peptide epitopes in SARS-CoV-2 spike (S), nucleocapsid (N), membrane, and envelope proteins.

公开(公告)号：US20220160767A1

公开(公告)日：2022-05-26

申请号：US17537816

申请日：2021-11-30

申请人： CHILDREN'S NATIONAL MEDICAL CENTER

发明人： Patrick HANLEY ,  Christopher LAZARSKI ,  Michael KELLER ,  Catherine BOLLARD

IPC分类号： A61K35/17 ,  A61K39/00 ,  A61K39/12 ,  C07K14/005 ,  C07K14/54 ,  A61P31/14

摘要： The disclosure relates to methods of culturing and expanding CD4+ and/or CD8+ T cells in culture. In some embodiments, the methods include expanding, proliferating and storing lymphocytes in tissue culture by exposing the lymphocytes to a combination of cytokines and/or nucleic acids expressing cytokines or functional fragments or variants thereof. The disclosure further relates to methods of generating and manufacturing CD4+ and/or CD8+ T cells that are specific to one or a plurality of viral antigens.

公开(公告)号：US20210380943A1

公开(公告)日：2021-12-09

申请号：US17404105

申请日：2021-08-17

申请人： CHILDREN'S NATIONAL MEDICAL CENTER

发明人： Catherine BOLLARD ,  Conrad CRUZ ,  Patrick HANLEY

IPC分类号： C12N5/0783 ,  A61K39/295 ,  C07K14/535 ,  C07K14/075 ,  C07K14/54 ,  C07K14/55 ,  A61K39/00 ,  A61K35/17

摘要： Safe, rapid, and efficient methods for producing antigen-specific T cells recognizing human papilloma virus (HPV antigens); HPV-specific T cells, and methods for treating HPV infections and HPV-related malignancies by adoptive transfer of HPV-specific T cells.

公开(公告)号：US20210277355A1

公开(公告)日：2021-09-09

申请号：US17331296

申请日：2021-05-26

申请人： CHILDREN'S NATIONAL MEDICAL CENTER

发明人： Catherine BOLLARD ,  Conrad CRUZ ,  Patrick HANLEY

IPC分类号： C12N5/0783 ,  A61K39/295 ,  C07K14/535 ,  C07K14/075 ,  C07K14/54 ,  C07K14/55 ,  A61K39/00 ,  A61K35/17

摘要： Safe, rapid and efficient methods for producing virus-specific or other antigen-specific T-cells from cord blood and other samples containing naive immune cells.

公开(公告)号：US20180072990A1

公开(公告)日：2018-03-15

申请号：US15563854

申请日：2016-03-21

申请人： CHILDREN'S NATIONAL MEDICAL CENTER

发明人： Catherine BOLLARD ,  Conrad CRUZ ,  Patrick HANLEY

IPC分类号： C12N5/0783 ,  C07K14/075 ,  C07K14/535 ,  C07K14/54 ,  C07K14/55 ,  A61K39/295 ,  A61K35/17

CPC分类号： C12N5/0636 ,  A61K35/17 ,  A61K39/00 ,  A61K39/295 ,  A61K2039/5158 ,  C07K14/075 ,  C07K14/535 ,  C07K14/5406 ,  C07K14/55 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2501/51 ,  C12N2501/59 ,  C12N2502/1121 ,  Y02A50/39 ,  Y02A50/396 ,  Y02A50/467

摘要： Safe, rapid and efficient methods for producing virus-specific or other antigen-specific T-cells from cord blood and other samples containing naive immune cells.