-
公开(公告)号：US09994627B2
公开(公告)日：2018-06-12
申请号：US14352734
申请日：2012-09-28
发明人： Yeo-Wook Koh , Sang-Yong Lee , Cook-Hee Kim , Seung-Hui Lee , Ha-Na Kim , Su-Yon Kim , Jin-Hyun Seong , Yong-Hyun Cho
IPC分类号： C07K14/505 , C07K1/14 , C07K1/16 , C12N5/00 , C12N15/00
CPC分类号： C07K14/505 , C07K1/14 , C07K1/16 , C12N5/00 , C12N15/00
摘要： The present invention relates to a method for purifying an erythropoietin analog having a low isoelectric point below 4 by adding an N-linked sugar chain with high purity. In accordance with the present invention, the erythropoietin analog having an isoelectric point below 4, which is an isoform having more sialic acid residues, can be effectively purified via three-step chromatographic processes in short time at lower cost.
-
2.发明申请METHODS FOR PURIFYING ERYTHROPOIETIN ANALOGS HAVING LOWER ISOELECTRIC POINT 有权用于纯化具有较低电压点的红细胞膜蛋白模拟物的方法公开(公告)号：US20140243510A1
公开(公告)日：2014-08-28
申请号：US14352734
申请日：2012-09-28
发明人： Yeo-Wook Koh , Sang-Yong Lee , Cook-Hee Kim , Seung-Hui Lee , Ha-Na Kim , Su-Yon Kim , Jin-Hyun Seong , Yong-Hyun Cho
IPC分类号： C07K14/505
CPC分类号： C07K14/505 , C07K1/14 , C07K1/16 , C12N5/00 , C12N15/00
摘要： The present invention relates to a method for purifying an erythropoietin analog having a low isoelectric point below 4 by adding an N-linked sugar chain with high purity. In accordance with the present invention, the erythropoietin analog having an isoelectric point below 4, which is an isoform having more sialic acid residues, can be effectively purified via three-step chromatographic processes in short time at lower cost.
摘要翻译： 本发明涉及通过添加高纯度的N-连接糖链来纯化低等电点低于4的促红细胞生成素类似物的方法。 根据本发明，具有较低唾液酸残基的等电点低于4的促红细胞生成素类似物可以通过三步色谱法在短时间内以较低成本有效地纯化。
-
搜索结果
2 条记录 (耗时 0.017 秒)
