公开(公告)号：US11186642B2

公开(公告)日：2021-11-30

申请号：US15439823

申请日：2017-02-22

申请人： City of Hope ,  Thomas Jefferson University

发明人： John C. Williams ,  Ulrich Rodeck ,  Joshua M. Donaldson ,  Csaba Kari

IPC分类号： C07K16/28 ,  C07K16/30 ,  C07K16/32

摘要： In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a cross-masked mAb heterodimer complex is provided, comprising a first masked mAb, comprising a first signal sequence, a first masking epitope sequence, a first linker that is cleavable by a protease specific to a target tissue, and a first antibody or fragment thereof; and a second masked mAb, comprising a second signal sequence, a second masking epitope sequence, a second linker that is cleavable by a protease specific to a target tissue, and a second antibody or fragment thereof.

公开(公告)号：US20230085485A1

公开(公告)日：2023-03-16

申请号：US17660603

申请日：2022-04-25

申请人： CITY OF HOPE ,  THOMAS JEFFERSON UNIVERSITY

发明人： John C. Williams ,  Cindy Zer ,  Kendra N. Avery ,  Ulrich Rodeck ,  Joshua M. Donaldson ,  Csaba Kari

IPC分类号： A61K47/55 ,  C07K16/28 ,  C07K16/30

摘要： In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a masked monoclonal antibody (mAb) is provided, which includes a therapeutic mAb and a mask, the mask comprising protein A and protein L attached by a protease cleavable linker.

公开(公告)号：US11311622B2

公开(公告)日：2022-04-26

申请号：US16460957

申请日：2019-07-02

申请人： CITY OF HOPE ,  Thomas Jefferson University

发明人： John C. Williams ,  Cindy Zer ,  Kendra N. Avery ,  Ulrich Rodeck ,  Joshua M. Donaldson ,  Csaba Kari

IPC分类号： A61K47/55 ,  C07K16/28 ,  C07K16/30 ,  C07K16/22

摘要： In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a masked monoclonal antibody (mAb) is provided, which includes a therapeutic mAb and a mask, the mask comprising protein A and protein L attached by a protease cleavable linker.

公开(公告)号：US10357571B2

公开(公告)日：2019-07-23

申请号：US14949648

申请日：2015-11-23

申请人： City of Hope ,  Thomas Jefferson University

发明人： John C. Williams ,  Cindy Zer ,  Kendra N. Avery ,  Ulrich Rodeck ,  Joshua M. Donaldson ,  Csaba Kari

IPC分类号： C07K16/28 ,  C07K16/30 ,  A61K47/48 ,  A61K47/55

摘要： In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a masked monoclonal antibody (mAb) is provided, which includes a therapeutic mAb and a mask, the mask comprising protein A and protein L attached by a protease cleavable linker.

公开(公告)号：US20200164077A1

公开(公告)日：2020-05-28

申请号：US16460957

申请日：2019-07-02

申请人： CITY OF HOPE

发明人： John C. Williams ,  Cindy Zer ,  Kendra N. Avery ,  Ulrich Rodeck ,  Joshua M. Donaldson ,  Csaba Kari

IPC分类号： A61K47/55 ,  C07K16/30 ,  C07K16/28

摘要： In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a masked monoclonal antibody (mAb) is provided, which includes a therapeutic mAb and a mask, the mask comprising protein A and protein L attached by a protease cleavable linker.