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公开(公告)号：US20230085485A1
公开(公告)日：2023-03-16
申请号：US17660603
申请日：2022-04-25
发明人： John C. Williams , Cindy Zer , Kendra N. Avery , Ulrich Rodeck , Joshua M. Donaldson , Csaba Kari
摘要： In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a masked monoclonal antibody (mAb) is provided, which includes a therapeutic mAb and a mask, the mask comprising protein A and protein L attached by a protease cleavable linker.
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公开(公告)号：US11311622B2
公开(公告)日：2022-04-26
申请号：US16460957
申请日：2019-07-02
发明人： John C. Williams , Cindy Zer , Kendra N. Avery , Ulrich Rodeck , Joshua M. Donaldson , Csaba Kari
摘要： In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a masked monoclonal antibody (mAb) is provided, which includes a therapeutic mAb and a mask, the mask comprising protein A and protein L attached by a protease cleavable linker.
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公开(公告)号：US10357571B2
公开(公告)日：2019-07-23
申请号：US14949648
申请日：2015-11-23
发明人： John C. Williams , Cindy Zer , Kendra N. Avery , Ulrich Rodeck , Joshua M. Donaldson , Csaba Kari
摘要： In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a masked monoclonal antibody (mAb) is provided, which includes a therapeutic mAb and a mask, the mask comprising protein A and protein L attached by a protease cleavable linker.
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公开(公告)号：US20200164077A1
公开(公告)日：2020-05-28
申请号：US16460957
申请日：2019-07-02
申请人： CITY OF HOPE
发明人： John C. Williams , Cindy Zer , Kendra N. Avery , Ulrich Rodeck , Joshua M. Donaldson , Csaba Kari
摘要： In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a masked monoclonal antibody (mAb) is provided, which includes a therapeutic mAb and a mask, the mask comprising protein A and protein L attached by a protease cleavable linker.
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公开(公告)号：US09669108B2
公开(公告)日：2017-06-06
申请号：US14453586
申请日：2014-08-06
申请人： City of Hope
发明人： John C. Williams , David A. Horne , Yuelong Ma , Heng Wei Chang , Joshua M. Donaldson , Cindy Zer , Krzysztof Bzymek , Kendra N. Avery , Jun Xie
IPC分类号： C07K16/18 , C07K7/00 , A61K47/48 , A61K38/00 , A61K39/00 , A61K51/10 , C07K16/28 , C07K16/32 , B82Y5/00
CPC分类号： A61K47/6811 , A61K47/66 , A61K47/6813 , A61K47/6851 , A61K47/6877 , A61K47/6897 , A61K51/1087 , B82Y5/00 , C07K16/18 , C07K16/2863 , C07K16/32 , C07K2299/00 , C07K2317/34 , C07K2317/40 , C07K2317/55 , C07K2317/567 , C07K2317/622 , C07K2317/92
摘要： Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.
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