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公开(公告)号：US20240299533A1
公开(公告)日：2024-09-12
申请号：US18574973
申请日：2022-06-30
发明人： Steffen Mueller , John Robert Coleman , Ying Wang , Chen Yang , Yutong Song
IPC分类号： A61K39/215 , A61K9/00 , A61K39/00 , A61P31/14 , C07K14/005 , C12N7/00
CPC分类号： A61K39/215 , A61K9/0043 , A61P31/14 , C07K14/005 , C12N7/00 , A61K2039/5254 , A61K2039/543 , A61K2039/545 , C12N2770/20021 , C12N2770/20022 , C12N2770/20034
摘要： Described herein are modified SARS-CoV-2 variants. These viruses have been recoded, for example, codon deoptimized or codon pair bias deoptimized and are useful for reducing the likelihood or severity of a SARS-CoV-2 variant infection, preventing a SARS-CoV-2 variant infection, eliciting and immune response, or treating a SARS-CoV-2 variant infection.
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公开(公告)号：US20230117167A1
公开(公告)日：2023-04-20
申请号：US17794862
申请日：2021-01-27
发明人： Steffen Mueller , John Robert Coleman , Ying Wang , Chen Yang
IPC分类号： C07K14/005 , A61K39/215 , A61P31/14
摘要： Described herein are modified SARS-CoV-2 coronaviruses. These viruses have been recoded, for example, codon deoptimized or codon pair bias deoptimized and are useful for reducing the likelihood or severity of a SARS-CoV-2 coronavirus infection, preventing a SARS-CoV-2 coronavirus infection, eliciting and immune response, or treating a SARS-CoV-2 coronavirus infection.
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公开(公告)号：US20230340423A1
公开(公告)日：2023-10-26
申请号：US18010740
申请日：2021-07-07
申请人： CODAGENIX INC.
发明人： John Robert Coleman , Steffen Mueller , Chen Yang , Ying Wang , Yutong Song
CPC分类号： C12N7/00 , C12Q1/70 , C12Q1/686 , C12N2770/20021 , C12N2770/24121
摘要： The present invention describes methods of generating a modified viral genome, producing infectious RNA, and generating modified viruses. The modified viral genome, infections RNA, and modified viruses comprise deoptimized nucleic acids; for example, codon-pair deoptimized or synonymous codon deoptimized. These modified viruses can be used in vaccines and methods of eliciting a protective immune response.
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4.发明申请公开(公告)号：US20210228705A1
公开(公告)日：2021-07-29
申请号：US16769102
申请日：2018-12-21
申请人： CODAGENIX INC.
发明人： John Robert Coleman , Steffen Mueller , Chen Yang , Ying Wang , Charles Stauft
IPC分类号： A61K39/13 , A61K39/145 , C12N7/00
摘要： The present invention is the use of designed recombinant viruses for the treatment of various forms of malignant tumors. The recombinant viruses of the invention are those in which one or more regions of the wild type virus was exchanged with a synthetic recoded sequence that reduces the codon pair score relative to human codon pair bias, or that increase the number for CpG di-nucleotides, or that increases the number of UpA di-nucleotides. The method of the present invention is particularly useful for the treatment of malignant tumors in various organs, such as: breast, skin, colon, bronchial passage, epithelial lining of the gastrointestinal, upper respiratory and genito-urinary tracts, liver, prostate and the brain. Astounding remissions in experimental animals have been demonstrated for the treatment of malignant glioblastoma multiforme, as well as for the treatment of breast cancer and melanoma as well.
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公开(公告)号：US20240293527A1
公开(公告)日：2024-09-05
申请号：US18572482
申请日：2022-07-07
申请人： Codagenix Inc.
发明人： John Robert Coleman , Steffen Mueller , Ying Wang , Chen Yang
IPC分类号： A61K39/12 , A61K39/00 , A61P37/04 , C07K14/005
CPC分类号： A61K39/12 , A61P37/04 , C07K14/005 , A61K2039/5254 , A61K2039/545 , A61K2039/585 , C12N2770/24122 , C12N2770/24134 , C12N2770/24162 , C12N2770/24171
摘要： The present invention relates to deoptimized Yellow Fever viruses and their uses for the treatment of various forms of malignant tumors, and as vaccines against Yellow Fever. The method of the present invention is particularly useful for the treatment of malignant tumors in various organs, such as: breast, skin, colon, bronchial passage, epithelial lining of the gastrointestinal, upper respiratory and genito-urinary tracts, liver, prostate and the brain.
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