公开(公告)号：US3888873A

公开(公告)日：1975-06-10

申请号：US39195073

申请日：1973-08-27

Applicant: COLGATE PALMOLIVE CO

Inventor： FREEDMAN JULES

IPC: C07D495/04 ,  C07D85/22

CPC classification number: C07D495/04

Abstract: The compounds are 4H(1)benzothiopyrano(3,4-d)isoxazoles useful as pharmaceutical agents, especially sedatives or central nervous system depressants. A compound disclosed is N-methyl4H(1)benzothiopyrano(3,4-d)isoxazole-3-carboxamide-5,5-dioxide.

公开(公告)号：US3651142A

公开(公告)日：1972-03-21

申请号：US3651142D

申请日：1969-02-06

Applicant: COLGATE PALMOLIVE CO

Inventor： FREEDMAN JULES

IPC: A61K31/13 ,  A61K31/135 ,  A61P25/24 ,  A61P25/26 ,  B01J23/00 ,  C07B61/00 ,  C07C67/00 ,  C07C213/00 ,  C07C215/44 ,  C07C91/00

CPC classification number: A61K31/135 ,  C07C215/44

Abstract: THE COMPOUNDS ARE 3-AMINO-2(3,4-DISUBSTITUTED)BICYCLO(2.2.2)LOCTAN-2-OLS WHICH ARE USEFUL IN THE TREATMENT OF DEPRESSION. REPRESENTATIVE COMPOUNDS DISCLOSED IN THE APPLICATION ARE N-METHYL-2-(3,4-DICHLOROPHENYL)-3-AMINOBICYCLO(2.2.2)OCTAN - 2-OL HYDROCHLORIDE, N-ISOPROPY-2(3,4-DICHLOROPHENYL)-3-AMINOBICYCLO(2.2.2)OCTAN - 2 - OL, AND N,N-DIMETHYL - 2 - (3,4-DICHLOROPHENYL)-3-AMINOBICYCLO(2.2.2)OCTAN-2-OL HYDROCHLORIDE.

公开(公告)号：US3899512A

公开(公告)日：1975-08-12

申请号：US46260474

申请日：1974-04-22

Applicant: COLGATE PALMOLIVE CO

Inventor： FREEDMAN JULES

IPC: C07D313/08 ,  C07D313/10

CPC classification number: C07D313/10 ,  C07D313/08

Abstract: The compounds are benzoxepinones which are central nervous system depressants. A compound disclosed is 8,9,10,11-tetrahydro3-hydroxydibenz(b,d)oxepin-6(7H)one.

Abstract translation: 这些化合物是作为中枢神经系统抑制剂的苯并酮。 所公开的化合物是8,9,10,11-四氢-3-羟基二苯并[b，d]氧杂七环素-6（7H）酮。

公开(公告)号：US3692796A

公开(公告)日：1972-09-19

申请号：US3692796D

申请日：1970-08-27

Applicant: COLGATE PALMOLIVE CO

Inventor： FREEDMAN JULES

IPC: C07D311/22 ,  C07D85/22

CPC classification number: C07D311/22

Abstract: 4H(1)benzopyrano(3,4-d)isoxazole derivatives substituted in the 3-position which are useful as pharmaceutical agents, especially anti-inflammatory agents. They are also useful in preparing structurally related pharmaceutical compounds of known utility. In addition, they are useful as intermediates in the preparation of wood preservatives, mothproofing agents and pickling inhibitors. Representative of the compounds disclosed are 4H(1)benzopyrano (3,4-d)isoxazole-3-carboxamide, ethyl 4H(1)benzopyrano(3,4-d)isoxazole-3-carboxylate and N-methyl4H(1)benzopyrano(3,4-d)isoxazole-3-thiocarboxamide.

Abstract translation: 4H [1]苯并吡喃并[3,4-d]异恶唑衍生物，它们可用作药剂，特别是抗炎剂。 它们也可用于制备已知效用的结构相关的药物化合物。 此外，它们可用作制备木材防腐剂，防蛀剂和酸洗抑制剂的中间体。 所公开的化合物的代表是4H [1]苯并吡喃并[3,4-d]异恶唑-3-甲酰胺，4H [1]苯并吡喃并[3,4-d]异恶唑-3-甲酸乙酯和N-甲基-4H- [1 ]苯并吡喃并[3,4-d]异恶唑-3-硫代甲酰胺。

公开(公告)号：US3553229A

公开(公告)日：1971-01-05

申请号：US3553229D

申请日：1967-09-26

Applicant: COLGATE PALMOLIVE CO

Inventor： FREEDMAN JULES

IPC: C07D498/04 ,  C07D85/22

CPC classification number: C07D498/04

Abstract: THE COMPOUNDS ARE DERIVATIVES OF 3-ALKANOL-4H(1)BENZOPYRANO(3,4-D)ISOXAZOLES USEFUL IN THE PREPARATION OF WOOD PRESERVATIVES, MOTH PROOFING AGENTS, PICKLING INHIBITORS AND PHARAMACEUTICAL AGENTS. TWO OF THE COMPOUNDS DISCLOSED ARE 4H(1)BENZOPYRANO(3,4-D)ISOXAZOLE3-METHANOL AND 4H(1)BENZOPYRANO(3,4 - D)ISOXAZOLE-3METHANOL CARBAMATE.

公开(公告)号：US3707476A

公开(公告)日：1972-12-26

申请号：US3707476D

申请日：1970-10-30

Applicant: COLGATE PALMOLIVE CO

Inventor： FREEDMAN JULES

IPC: B65G53/30 ,  C07D498/04 ,  C07D85/22

CPC classification number: C07D498/04 ,  B65G53/30

Abstract: THE COMPOUNDS ARE DERIVATIVES OF 3-ALKANOL-4-H(1) BENZOPYRANO (3,4-D) ISOXAZOLES USEFUL IN THE PREPARATION OF WOOD PRESERVATIVES, MOTHPROOFING AGENTS, PICKLING INHIBITORS AND PHARMACEUTICAL AGENTS, REPRESENTATIVE OF THE COMPOUNDS DISCLOSED IN 4H(1) BENZOPYRANO (3,4 - D) ISOXAZOL-3-METHANOL.

公开(公告)号：US3637747A

公开(公告)日：1972-01-25

申请号：US3637747D

申请日：1969-04-30

Applicant: COLGATE PALMOLIVE CO

Inventor： FREEDMAN JULES ,  JUDD CLAUDE I

IPC: C07D209/04 ,  C07D209/10 ,  C07D209/14

CPC classification number: C07D209/04 ,  C07D209/10 ,  C07D209/14

Abstract: THE COMPOUNDS ARE 3-(2-AMINOPHENYL) INDOLES WHICH ARE USEFUL AS ANTICONVULSANT AGENT AND CENTRAL NERVOUS SYSTEM DEPRESSNTS. THE COMPOUNDS MAY ALSO BE USED AS INTERMEDIATES IN THE PREPARATION OF PICKLING AGENTS, MOTHPROOFING AGENTS AND WOOD PRESERVATIVES. REPRESENTATIVE OF THE COMPOUNDS DISCLOSED IS 3-(2-ACETAMIDO-5-CHLORO)PHENYLINDOLE.

公开(公告)号：US3553230A

公开(公告)日：1971-01-05

申请号：US3553230D

申请日：1967-09-26

Applicant: COLGATE PALMOLIVE CO

Inventor： FREEDMAN JULES

IPC: C07D311/22 ,  C07D85/22

CPC classification number: C07D311/22

Abstract: THE COMPOUNDS ARE 3-AMINALKYL AND 3-AMINO DERIVATIVES OF 4H(1)BENZOPYRANO(3,4-D)ISOXAZOLES USEFUL IN THE PREPARATION OF WOOD PRESERAVITIVES, MOTH PROOFING AGENTS, PICKLING INHIBITORS AND PHARMACEUTICAL AGENTS. A SPECIES DISCLOSED IS 3 - AMINOMETHYL - 4H(1)BENZOPYRANO(3,4-D) ISOXAZOLE.

公开(公告)号：US3553228A

公开(公告)日：1971-01-05

申请号：US3553228D

申请日：1967-09-26

Applicant: COLGATE PALMOLIVE CO

Inventor： FREEDMAN JULES

IPC: C07D498/04 ,  C07D85/22

CPC classification number: C07D498/04

Abstract: THE COMPOUNDS ARE 4H(1)BENZOPYRANO(3,4-D)ISOXAZOLES SUBSTITUTED IN THE 3 POSITION WHICH ARE USEFUL IN THE PREPARATION OF WOOD PRESERAVITIVES, MOTH PROOFING AGENTS, PICKLING INHIBITORS AND SKELETAL MUSCLE RELAXANTS. TWO SPECIDCES DISCLOSED ARE 4H(1)BENZOPYRANO(3,4-D)ISOXAZOLE3 - CARBOXYLIC ACID AND 4H(1)BENZOPYRANO(3,4-D)ISOXAZOLE-3-CARBOXAMIDE.