公开(公告)号：US20220378678A1

公开(公告)日：2022-12-01

申请号：US17825372

申请日：2022-05-26

Applicant: Colgate-Palmolive Company

Inventor： Murilo Nogueira NAKAJIMA ,  Saide TANG ,  Enzo UTIMA ,  Guofeng XU ,  Paloma PIMENTA

IPC: A61K8/43 ,  A61K8/73 ,  A61Q11/00

Abstract: This application provides, among other things, oral care compositions where the addition of a stabilizing amount of a nonionic gelling and thickening agent, (e.g., hydroxyethyl cellulose (HEC)) and an effective amount of a zwitterionic surfactant (e.g., a betaine zwitterionic surfactant) (e.g., cocamidopropyl betaine), to formulations comprising a bisbiguanide (e.g., chlorhexidine (CHX)) agent, and optionally an effective amount of abrasive silica, allows for proper structure and consistency to the formulation and to allow it to be used as a gel or a toothpaste to facility delivery of chlorhexidine, among other actives, to the teeth or gums with acceptable stability and foaming.

公开(公告)号：US20220387279A1

公开(公告)日：2022-12-08

申请号：US17825365

申请日：2022-05-26

Applicant: Colgate-Palmolive Company

Inventor： Murilo Nogueira NAKAJIMA ,  Saide TANG ,  Betty WON ,  Enzo UTIMA ,  Guofeng XU ,  Paloma PIMENTA ,  Sarita Vera MELLO ,  Melissa MUIR

IPC: A61K8/43 ,  A61Q11/00 ,  A61K8/73 ,  A61K8/49 ,  A61K8/04

Abstract: This application provides, among other things, oral care compositions where the addition of a stabilizing amount of a nonionic gelling and thickening agent, (e.g., hydroxyethyl cellulose (HEC)), to formulations comprising a bisbiguanide (e.g., chlorhexidine (CHX)) agent allows for proper structure and consistency to the formulation and to allow it to be used as a gel or a toothpaste to facility delivery of chlorhexidine, among other actives, to the teeth or gums.

公开(公告)号：US20210000709A1

公开(公告)日：2021-01-07

申请号：US16840857

申请日：2020-04-06

Applicant: Colgate-Palmolive Company

Inventor： Shaoyi ZHANG ,  Saide TANG ,  Carl MYERS ,  Guofeng XU

IPC: A61K8/21 ,  A61K8/20 ,  A61K8/19 ,  A61K8/27 ,  A61K8/41 ,  A61K8/55 ,  A61Q11/00

Abstract: This application relates to novel aqueous oral care compositions useful for combining and delivering incompatible stannous fluoride or stannous chloride and potassium salts in a high-water composition, for example, to provide effective caries prevention, protection against dental erosion, and relief from dental hypersensitivity. The compositions comprise stannous fluoride or stannous chloride, nitric acid or a water-soluble nitrate salt, a water-soluble alkali metal polyphosphate and more than 10% water, by weight of the composition.

公开(公告)号：US20240050332A1

公开(公告)日：2024-02-15

申请号：US18258248

申请日：2021-12-20

Applicant: Colgate-Palmolive Company

Inventor： Carl MYERS ,  Guofeng XU ,  Shaoyi ZHANG ,  Saide TANG

IPC: A61K8/21 ,  A61Q11/00 ,  A61K8/24 ,  A61K8/55

CPC classification number: A61K8/21 ,  A61Q11/00 ,  A61K8/24 ,  A61K8/55

Abstract: This application relates to novel aqueous oral care compositions useful for combining and delivering incompatible stannous fluoride, and/or stannous chloride, and/or stannous pyrophosphate and potassium salts, with a polyphosphate source, wherein the polyphosphate source comprises three or more phosphate moieties or units, in a high-water composition, for example, to provide effective caries prevention, protection against dental erosion, relief from dental hypersensitivity, and to treat or reduce malodor.

公开(公告)号：US20190053992A1

公开(公告)日：2019-02-21

申请号：US15680391

申请日：2017-08-18

Applicant: Colgate-Palmolive Company

Inventor： Saide TANG ,  Lin FEI ,  Suman CHOPRA

IPC: A61K8/25 ,  A61Q11/00 ,  A61K8/34 ,  A61K8/19 ,  A61K8/27 ,  A61K8/11 ,  B01J13/02 ,  B01J13/22

CPC classification number: A61K8/25 ,  A61K8/11 ,  A61K8/19 ,  A61K8/27 ,  A61K8/345 ,  A61K2800/621 ,  A61K2800/651 ,  A61Q11/00 ,  B01J13/02 ,  B01J13/20 ,  B01J13/22

Abstract: Methods for preparing high loading core shell silica (CSS) particles, or CSS particles having a relatively greater amount of surface active silicate groups than CSS particles prepared according to conventional methods is provided. The method may include contacting silica particles with a base having a first metal ion to produce core shell silica particles. Each of the core shell silica particles may include a silica core and a silicate of the first metal ion etched on a surface of the silica core. The method may also include contacting each of the core shell silica particles having the silicate of the first metal ion with an acidic aqueous solution including a metal salt having a second metal ion to produce core shell silica particles including the silica core and a silicate of the second metal ion on the surface of the silica core.

公开(公告)号：US20210401705A1

公开(公告)日：2021-12-30

申请号：US17359026

申请日：2021-06-25

Applicant: Colgate-Palmolive Company

Inventor： Ningwei LI ,  Hongwei SHEN ,  Saide TANG ,  Betty WON ,  Viktor DUBOVOY ,  Long PAN

IPC: A61K8/43 ,  A61Q11/00 ,  A61K8/24

Abstract: This application provides, among other things, novel aqueous oral care compositions useful for combining and delivering poorly compatible ingredients, in particular, chlorhexidine and polyphosphate salts, by formulating the composition with a surfactant.

公开(公告)号：US20200206125A1

公开(公告)日：2020-07-02

申请号：US16232964

申请日：2018-12-26

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： Saide TANG ,  Lin FEI ,  Suman CHOPRA ,  Abhishek AGRAWAL

IPC: A61K8/9789 ,  A61K8/25 ,  A61Q11/00

Abstract: An oral care composition and methods for whitening teeth are disclosed herein. The whitening composition may include an orally acceptable vehicle and one or more abrasives. The one or more abrasives may include at least one plant-based abrasive. The method for whitening teeth may include contacting the oral care composition with surfaces of the teeth at least twice a day for at least nine days.