公开(公告)号：US20220387279A1

公开(公告)日：2022-12-08

申请号：US17825365

申请日：2022-05-26

Applicant: Colgate-Palmolive Company

Inventor： Murilo Nogueira NAKAJIMA ,  Saide TANG ,  Betty WON ,  Enzo UTIMA ,  Guofeng XU ,  Paloma PIMENTA ,  Sarita Vera MELLO ,  Melissa MUIR

IPC: A61K8/43 ,  A61Q11/00 ,  A61K8/73 ,  A61K8/49 ,  A61K8/04

Abstract: This application provides, among other things, oral care compositions where the addition of a stabilizing amount of a nonionic gelling and thickening agent, (e.g., hydroxyethyl cellulose (HEC)), to formulations comprising a bisbiguanide (e.g., chlorhexidine (CHX)) agent allows for proper structure and consistency to the formulation and to allow it to be used as a gel or a toothpaste to facility delivery of chlorhexidine, among other actives, to the teeth or gums.

公开(公告)号：US20220142887A1

公开(公告)日：2022-05-12

申请号：US17580224

申请日：2022-01-20

Applicant: Colgate-Palmolive Company

Inventor： Enzo UTIMA ,  Abraham CAZES ,  Erico PRAT

IPC: A61K8/44 ,  A61K8/21 ,  A61K8/34 ,  A61Q11/00

Abstract: This invention relates to high-water oral care compositions comprising a basic amino acid or salt thereof, together with a precipitated calcium carbonate, glycerol, and to methods of using and of making these compositions.

公开(公告)号：US20200009030A1

公开(公告)日：2020-01-09

申请号：US16487224

申请日：2018-02-21

Applicant: Colgate-Palmolive Company

Inventor： Enzo UTIMA ,  Tatiana CINQUETTI ,  Fernanda CORREA ,  Paulo FOCASSIO ,  Debora PEDROSO

IPC: A61K8/19 ,  A61K8/34 ,  A61K8/365 ,  A61Q11/00

Abstract: Disclosed herein are improved oral care formulations comprising precipitated calcium carbonate (PCC) and preservative combinations selected from the group consisting of i) phenethyl alcohol and caprylyl glycol, and ii) benzyl alcohol and caprylyl glycol. Methods of making and using the compositions are also provided.

公开(公告)号：US20220378678A1

公开(公告)日：2022-12-01

申请号：US17825372

申请日：2022-05-26

Applicant: Colgate-Palmolive Company

Inventor： Murilo Nogueira NAKAJIMA ,  Saide TANG ,  Enzo UTIMA ,  Guofeng XU ,  Paloma PIMENTA

IPC: A61K8/43 ,  A61K8/73 ,  A61Q11/00

Abstract: This application provides, among other things, oral care compositions where the addition of a stabilizing amount of a nonionic gelling and thickening agent, (e.g., hydroxyethyl cellulose (HEC)) and an effective amount of a zwitterionic surfactant (e.g., a betaine zwitterionic surfactant) (e.g., cocamidopropyl betaine), to formulations comprising a bisbiguanide (e.g., chlorhexidine (CHX)) agent, and optionally an effective amount of abrasive silica, allows for proper structure and consistency to the formulation and to allow it to be used as a gel or a toothpaste to facility delivery of chlorhexidine, among other actives, to the teeth or gums with acceptable stability and foaming.

公开(公告)号：US20210275413A1

公开(公告)日：2021-09-09

申请号：US17249588

申请日：2021-03-05

Applicant: Colgate-Palmolive Company

Inventor： Enzo UTIMA ,  Erico PRAT ,  Abraham CAZES ,  Paulo FOCASSIO ,  Murilo Nogueira NAKAJIMA

IPC: A61K8/21 ,  A61K8/24 ,  A61K8/27 ,  A61K8/34 ,  A61K8/46 ,  A61K8/44 ,  A61K8/73 ,  A61K8/86 ,  A61K8/81 ,  A61K8/04 ,  A61Q11/00

Abstract: The present invention provides calcium carbonate-based oral care compositions, in particular toothpastes comprising a thickening system comprising 0.2-0.5 wt. % xanthan gum and 0.2-0.5 wt. % synthetic polyacrylic acid polymer, as well as methods of using these compositions.

公开(公告)号：US20200306158A1

公开(公告)日：2020-10-01

申请号：US16822195

申请日：2020-03-18

Applicant: Colgate-Palmolive Company

Inventor： Enzo UTIMA ,  Abraham CAZES ,  Erico PRAT

IPC: A61K8/44 ,  A61Q11/00 ,  A61K8/21 ,  A61K8/34

Abstract: This invention relates to high-water oral care compositions comprising a basic amino acid or salt thereof, together with a precipitated calcium carbonate, glycerol, and to methods of using and of making these compositions.