公开(公告)号：US10342835B2

公开(公告)日：2019-07-09

申请号：US15969762

申请日：2018-05-02

申请人： COMPREHENSIVE AND INTEGRATIVE MEDICINE INSTITUTE

发明人： Chang Hyeong Lee ,  Sang Gyung Kim ,  Im Hee Shin ,  Seung Mo Kim ,  Joon Seok Byun ,  Ki Cheul Sohn ,  Sae Kwang Ku

IPC分类号： A61K38/19 ,  A61K36/232

摘要： The present invention relates to a composition for promoting proliferation of bone marrow derived stem cells using an angelicae gigantis radix extract, and more particularly, to a composition which administers a granulocyte colony-stimulating factor into an object, and administers the angelicae gigantis radix extract to the object to promote the proliferation of the bone marrow derived stem cells. The composition of the present invention solves side effects such as splenomegaly which were caused by a method of administering only the G-CSF for proliferation and differentiation of the stem cells, thereby significantly mitigating the side effects through co-administration of the angelicae gigantis radix extract, and further promoting the proliferation and the differentiation of the stem cells.

公开(公告)号：US10286040B2

公开(公告)日：2019-05-14

申请号：US15854613

申请日：2017-12-26

申请人： COMPREHENSIVE AND INTEGRATIVE MEDICINE INSTITUTE

发明人： Chang Hyeong Lee ,  Sang Gyung Kim ,  Im Hee Shin ,  Seung Mo Kim ,  Joon Seok Byun ,  Ki Cheul Sohn ,  Sae Kwang Ku

IPC分类号： A61K38/00 ,  A61K38/19 ,  C12N5/0789 ,  A61K36/804 ,  A61K36/076 ,  A61K36/232 ,  A61K36/234 ,  A61K36/258 ,  A61K36/284 ,  A61K36/484 ,  A61K36/65 ,  A61K36/07 ,  A61K36/64

摘要： The present invention relates to a composition for promoting the proliferation of stem cells derived from bone marrow using a palmultang extract, and more specifically, to a composition for promoting the proliferation of stem cells derived from bone marrow by administering a granulocyte colony-stimulating factor to a subject and then administering the palmultang extract to the subject. The composition of the present invention remarkably reduces side effects, such as enlargement of the spleen, which are caused by the administration of G-CSF alone for proliferation and differentiation of the stem cells, through administration in combination with the palmultang extract, thereby further promoting the proliferation and differentiation of stem cells.