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    Pharmaceutical composition for preventing and treating chronic obstructive pulmonary diseases, containing Phyllostachys nigra Munro var. henosis stapf extract as active ingredient
    6.
    发明授权
    Pharmaceutical composition for preventing and treating chronic obstructive pulmonary diseases, containing Phyllostachys nigra Munro var. henosis stapf extract as active ingredient 有权
    用于预防和治疗慢性阻塞性肺疾病的药物组合物，其含有Phyllostachys nigra Munro var。 乙肝提取物作为活性成分

    公开(公告)号：US09511108B2

    公开(公告)日：2016-12-06

    申请号：US14491785

    申请日：2014-09-19

    申请人： UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY

    发明人： Jinju Kim ,  Eunjung Ko ,  Eui Jeong Lee

    IPC分类号： A61K36/899 ,  A61K36/804 ,  A61K36/074

    CPC分类号： A61K36/899 ,  A23L33/105 ,  A61K36/074 ,  A61K36/804

    摘要： The present invention relates to a method for treating chronic obstructive pulmonary disease (COPD) comprising the step of administering the extract of Phyllostachys nigra Munro var. henosis Stapf as an active ingredient. Particularly, the extract of Phyllostachys nigra Munro var. henosis Stapf of the present invention can reduce the numbers of macrophages and neutrophils increased in bronchoalveolar lavage fluid (BALF) and is effective in preventing weight loss caused by chronic obstructive pulmonary disease and is effective in down-regulating significantly IL-6, TNF-α, IL-1β, MCP-1, and MMP-12, which are rapidly increased in bronchoalveolar lavage fluid, intrapulmonary tissue, and serum according to the development of chronic obstructive pulmonary disease. In addition, the extract of Phyllostachys nigra Munro var. henosis Stapf of the present invention has the effect of blocking the activation of NF-κB signal in intrapulmonary tissue and significantly reduces inflammatory cells in the tissues around alveoli as well as significantly reduces the size of the enlarged alveola. Therefore, the extract of Phyllostachys nigra Munro var. henosis Stapf of the present invention can be effectively used as an active ingredient of medicines and health food for the prevention and treatment of chronic obstructive pulmonary disease.

    摘要翻译： 本发明涉及一种治疗慢性阻塞性肺病（COPD）的方法，包括以下步骤：施用黑曲霉木瓜提取物 会阴Stapf作为活性成分。 特别是黑叶木麻黄提取物 本发明的发音Stapf可以减少支气管肺泡灌洗液（BALF）中增加的巨噬细胞和嗜中性粒细胞的数量，有效预防慢性阻塞性肺疾病引起的体重减轻，有效下调IL-6，TNF-α ，IL-1β，MCP-1和MMP-12，根据慢性阻塞性肺疾病的发展，其在支气管肺泡灌洗液，肺内组织和血清中迅速增加。 此外，Phyllostachys nigra Munro var。 本发明的发音Stapf具有阻断肺内组织中NF-κB信号的活化并显着减少肺泡周围组织中的炎症细胞的作用，并且显着减小扩大的肺泡的大小。 因此，Phyllostachys nigra Munro var。 本发明的发音Stapf可以有效地用作预防和治疗慢性阻塞性肺疾病的药物和保健食品的活性成分。