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公开(公告)号：US20180017444A1
公开(公告)日：2018-01-18
申请号：US15517809
申请日：2015-10-08
Inventor： Valerio PINI , Priscila MONTEIRO KOSAKA , Francisco Javier TAMAYO DE MIGUEL , Montserrat CALLEJA GOMEZ , Daniel RAMOS VEGA , Oscar MALVAR VIDAL , Jose Jaime RUZ MARTINEZ , Mario ENCINAR DEL POZO
CPC classification number: G01J3/2803 , G01J3/0208 , G01J3/12 , G01J3/28 , G01J3/2823 , G01J2003/104 , G01J2003/106 , G01J2003/2813 , G01J2003/282 , G01J2003/2826 , G01N21/27 , G02B21/00
Abstract: The invention relates to a spectrophotometer, especially a spectrophotometer that can carry out simultaneous analysis at different points on the same sample (4), with a high spatial resolution and without requiring a mechanical system for physical scanning along the sample. This is obtained by the provision of means for processing the light received by the photodetectors (5), said processing means having a correlation wherein each of the photodetectors (5) corresponds to a spatial point on the sample (4).In the case of dark field applications, the present invention ensures the standardization of the data using the same measure.
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公开(公告)号：US20210223208A1
公开(公告)日：2021-07-22
申请号：US17058038
申请日：2019-05-27
Inventor： Eduardo GIL SANTOS , Jose Jaime RUZ MARTINEZ , Oscar MALVAR VIDAL , Javier TAMAYO DE MIGUEL , Montserrat CALLEJA GOMEZ
IPC: G01N29/02 , G01N29/036 , G01N29/24 , G01N29/34 , G02B6/293
Abstract: The invention relates to a method and a system of mechanical resonance transduction for analyte analysis, suitable for its use in the identification of nanoparticles in the range between 1 MHz and 300 GHz, said method being characterized in that it comprises the following steps: a) disposing at least one analyte, possessing at least one mechanical vibration mode, on at least one mechanical resonator sensor that possesses at least one mechanical vibration mode, selectable in a plurality of working frequencies; b) monitoring the mechanical spectra of the of the analyte and the resonator sensor; c) varying the at least one mechanical vibration mode until at least one mechanical vibration mode reaches a strong coupling situation with the at least one mechanical vibration mode; d) collecting the frequency data at which the strong coupling occurs; e) estimating the resonance frequency and quality factor of the at least one mechanical vibration mode from the strong coupling frequency data obtained in step d).
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公开(公告)号：US20200072829A1
公开(公告)日：2020-03-05
申请号：US16668005
申请日：2019-10-30
Inventor： Francisco Javier TAMAYO DE MIGUEL , Priscila MONTEIRO KOSAKA , Valerio PINI , Montserrat CALLEJA GOMÉZ , Jose Jaime RUZ MARTINEZ , Daniel RAMOS VEGA , Maria Ujue GONZALEZ SAGARDOY
IPC: G01N33/543 , G01N21/47 , G01N21/59 , G01N21/77 , G01N21/65 , G01N21/552
Abstract: The present invention relates to a system for biodetection applications comprising two basic elements, a substrate with a functionalized surface and a nanoparticle, the system being capable of enhancing the plasmonic effect of the nanoparticle. The invention also relates to a biosensor incorporating such system, in addition to the method for detecting and quantifying a target analyte selected in a sample using such system. Finally, the invention relates to a device which can detect the enhanced optoplasmonic effect of the nanoparticles by means of the system of the invention or by combining the detection of such optoplasmonic effect with the analysis of the changes in the mechanical characteristics in the substrate.
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公开(公告)号：US20170205405A1
公开(公告)日：2017-07-20
申请号：US15315029
申请日：2015-06-02
Inventor： Francisco Javier TAMAYO DE MIGUEL , Priscila MONTEIRO KOSAKA , Valerio PINI , Montserrat CALLEJA GOMÉZ , Jose Jaime RUZ MARTINEZ , Daniel RAMOS VEGA , Maria Ujue GONZALEZ SAGARDOY
IPC: G01N33/543 , G01N21/47 , G01N21/59 , G01N21/77
CPC classification number: G01N33/54346 , G01N21/47 , G01N21/554 , G01N21/59 , G01N21/658 , G01N21/77 , G01N21/7703 , G01N33/54373 , G01N2021/5903
Abstract: The present invention relates to a system for biodetection applications comprising two basic elements, a substrate with a functionalized surface and a nanoparticle, the system being capable of enhancing the plasmonic effect of the nanoparticle. The invention also relates to a biosensor incorporating such system, in addition to the method for detecting and quantifying a target analyte selected in a sample using such system. Finally, the invention relates to a device which can detect the enhanced optoplasmonic effect of the nanoparticles by means of the system of the invention or by combining the detection of such optoplasmonic effect with the analysis of the changes in the mechanical characteristics in the substrate.
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