公开(公告)号：US20230140770A1

公开(公告)日：2023-05-04

申请号：US17852242

申请日：2022-06-28

Applicant: CORNELL UNIVERSITY

Inventor： Ulrich B. Wiesner ,  Kai MA ,  Carlie Mendoza

IPC: A61K49/00 ,  A61K9/14 ,  A61P35/00 ,  A61B5/00 ,  A61K9/51

Abstract: An aqueous synthesis methodology for the preparation of silica nanoparticles (SNPs), core-shell SNPs having, for example, a size of 2 to 15 nm and narrow size-dispersion with size control below 1 nm, i.e. at the level of a single atomic layer. Different types of dyes, including near infrared (NIR) emitters, can be covalently encapsulated within and brightness can be enhanced via addition of extra silica shells. The surface may be functionalized with polyethylene glycol (PEG) groups and, optionally, specific surface ligands. This aqueous synthesis methodology also enables synthesis of 2 to 15 nm sized fluorescent core and core-shell aluminosilicate nanoparticles (ASNPs) which may also be surface functionalized. Encapsulation efficiency and brightness of highly negatively charged NIR fluorophores is enhanced relative to the corresponding SNPs without aluminum.

公开(公告)号：US20250114484A1

公开(公告)日：2025-04-10

申请号：US18908740

申请日：2024-10-07

Applicant: CORNELL UNIVERSITY

Inventor： Ulrich B. Wiesner ,  Kai Ma ,  Carlie Mendoza

IPC: C01B33/12 ,  B82Y40/00 ,  C01B33/26

Abstract: An aqueous synthesis methodology for the preparation of silica nanoparticles (SNPs), core-shell SNPs having, for example, a size of 2 to 15 nm and narrow size-dispersion with size control below 1 nm, i.e. at the level of a single atomic layer. Different types of dyes, including near infrared (NIR) emitters, can be covalently encapsulated within and brightness can be enhanced via addition of extra silica shells. The surface may be functionalized with polyethylene glycol (PEG) groups and, optionally, specific surface ligands. This aqueous synthesis methodology also enables synthesis of 2 to 15 nm sized fluorescent core and core-shell aluminosilicate nanoparticles (ASNPs) which may also be surface functionalized. Encapsulation efficiency and brightness of highly negatively charged NIR fluorophores is enhanced relative to the corresponding SNPs without aluminum.

公开(公告)号：US12115231B2

公开(公告)日：2024-10-15

申请号：US17852242

申请日：2022-06-28

Applicant: CORNELL UNIVERSITY

Inventor： Ulrich B. Wiesner ,  Kai Ma ,  Carlie Mendoza

IPC: A61K49/00 ,  A61B5/00 ,  A61K9/14 ,  A61K9/51 ,  A61P35/00

CPC classification number: A61K49/0093 ,  A61B5/0071 ,  A61K9/141 ,  A61K9/5115 ,  A61K9/5146 ,  A61K9/5192 ,  A61K49/0032 ,  A61P35/00

Abstract: An aqueous synthesis methodology for the preparation of silica nanoparticles (SNPs), core-shell SNPs having, for example, a size of 2 to 15 nm and narrow size-dispersion with size control below 1 nm, i.e. at the level of a single atomic layer. Different types of dyes, including near infrared (NIR) emitters, can be covalently encapsulated within and brightness can be enhanced via addition of extra silica shells. The surface may be functionalized with polyethylene glycol (PEG) groups and, optionally, specific surface ligands. This aqueous synthesis methodology also enables synthesis of 2 to 15 nm sized fluorescent core and core-shell aluminosilicate nanoparticles (ASNPs) which may also be surface functionalized. Encapsulation efficiency and brightness of highly negatively charged NIR fluorophores is enhanced relative to the corresponding SNPs without aluminum.

公开(公告)号：US11291737B2

公开(公告)日：2022-04-05

申请号：US15571420

申请日：2016-05-04

Applicant: Cornell University

Inventor： Ulrich B. Wiesner ,  Kai Ma ,  Carlie Mendoza

IPC: A61K49/00 ,  A61K9/14 ,  A61P35/00 ,  A61B5/00 ,  A61K9/51

Abstract: An aqueous synthesis methodology for the preparation of silica nanoparticles (SNPs), core-shell SNPs having, for example, a size of 2 to 15 nm and narrow size-dispersion with size control below 1 nm, i.e. at the level of a single atomic layer. Different types of dyes, including near infrared (NIR) emitters, can be covalently encapsulated within and brightness can be enhanced via addition of extra silica shells. The surface may be functionalized with polyethylene glycol (PEG) groups and, optionally, specific surface ligands. This aqueous synthesis methodology also enables synthesis of 2 to 15 nm sized fluorescent core and core-shell aluminosilicate nanoparticles (ASNPs) which may also be surface functionalized. Encapsulation efficiency and brightness of highly negatively charged NIR fluorophores is enhanced relative to the corresponding SNPs without aluminum.