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    ULTRASMALL NANOPARTICLES AND METHODS OF MAKING AND USING SAME
    1.
    发明申请
    ULTRASMALL NANOPARTICLES AND METHODS OF MAKING AND USING SAME 有权

    公开(公告)号：US20250114484A1

    公开(公告)日：2025-04-10

    申请号：US18908740

    申请日：2024-10-07

    Applicant: CORNELL UNIVERSITY

    Inventor： Ulrich B. Wiesner ,  Kai Ma ,  Carlie Mendoza

    IPC: C01B33/12 ,  B82Y40/00 ,  C01B33/26

    Abstract: An aqueous synthesis methodology for the preparation of silica nanoparticles (SNPs), core-shell SNPs having, for example, a size of 2 to 15 nm and narrow size-dispersion with size control below 1 nm, i.e. at the level of a single atomic layer. Different types of dyes, including near infrared (NIR) emitters, can be covalently encapsulated within and brightness can be enhanced via addition of extra silica shells. The surface may be functionalized with polyethylene glycol (PEG) groups and, optionally, specific surface ligands. This aqueous synthesis methodology also enables synthesis of 2 to 15 nm sized fluorescent core and core-shell aluminosilicate nanoparticles (ASNPs) which may also be surface functionalized. Encapsulation efficiency and brightness of highly negatively charged NIR fluorophores is enhanced relative to the corresponding SNPs without aluminum.

    Ultrasmall nanoparticles and methods of making and using same
    3.
    发明授权
    Ultrasmall nanoparticles and methods of making and using same 有权

    公开(公告)号：US12115231B2

    公开(公告)日：2024-10-15

    申请号：US17852242

    申请日：2022-06-28

    Applicant: CORNELL UNIVERSITY

    Inventor： Ulrich B. Wiesner ,  Kai Ma ,  Carlie Mendoza

    IPC: A61K49/00 ,  A61B5/00 ,  A61K9/14 ,  A61K9/51 ,  A61P35/00

    CPC classification number: A61K49/0093 ,  A61B5/0071 ,  A61K9/141 ,  A61K9/5115 ,  A61K9/5146 ,  A61K9/5192 ,  A61K49/0032 ,  A61P35/00

    Abstract: An aqueous synthesis methodology for the preparation of silica nanoparticles (SNPs), core-shell SNPs having, for example, a size of 2 to 15 nm and narrow size-dispersion with size control below 1 nm, i.e. at the level of a single atomic layer. Different types of dyes, including near infrared (NIR) emitters, can be covalently encapsulated within and brightness can be enhanced via addition of extra silica shells. The surface may be functionalized with polyethylene glycol (PEG) groups and, optionally, specific surface ligands. This aqueous synthesis methodology also enables synthesis of 2 to 15 nm sized fluorescent core and core-shell aluminosilicate nanoparticles (ASNPs) which may also be surface functionalized. Encapsulation efficiency and brightness of highly negatively charged NIR fluorophores is enhanced relative to the corresponding SNPs without aluminum.

    Ultrasmall nanoparticles and methods of making and using same
    4.
    发明授权
    Ultrasmall nanoparticles and methods of making and using same 有权

    公开(公告)号：US11291737B2

    公开(公告)日：2022-04-05

    申请号：US15571420

    申请日：2016-05-04

    Applicant: Cornell University

    Inventor： Ulrich B. Wiesner ,  Kai Ma ,  Carlie Mendoza

    IPC: A61K49/00 ,  A61K9/14 ,  A61P35/00 ,  A61B5/00 ,  A61K9/51

    Abstract: An aqueous synthesis methodology for the preparation of silica nanoparticles (SNPs), core-shell SNPs having, for example, a size of 2 to 15 nm and narrow size-dispersion with size control below 1 nm, i.e. at the level of a single atomic layer. Different types of dyes, including near infrared (NIR) emitters, can be covalently encapsulated within and brightness can be enhanced via addition of extra silica shells. The surface may be functionalized with polyethylene glycol (PEG) groups and, optionally, specific surface ligands. This aqueous synthesis methodology also enables synthesis of 2 to 15 nm sized fluorescent core and core-shell aluminosilicate nanoparticles (ASNPs) which may also be surface functionalized. Encapsulation efficiency and brightness of highly negatively charged NIR fluorophores is enhanced relative to the corresponding SNPs without aluminum.

    TWO-DIMENSIONAL MESOPOROUS SUPERLATTICES OF INORGANIC MATERIALS AND METHOD OF MAKING AND USING SAME
    8.
    发明申请
    TWO-DIMENSIONAL MESOPOROUS SUPERLATTICES OF INORGANIC MATERIALS AND METHOD OF MAKING AND USING SAME 有权

    公开(公告)号：US20220363553A1

    公开(公告)日：2022-11-17

    申请号：US17765766

    申请日：2020-10-05

    Applicant: CORNELL UNIVERSITY

    Inventor： Ulrich B. Wiesner ,  Kai Ma ,  Tangi Aubert

    IPC: C01B33/18 ,  C01B33/26

    Abstract: Porous compositions and methods of making and using same. The compositions may be one or more layer(s) of mesoporous inorganic materials. The mesoporous inorganic material(s) may be a plurality of inorganic nanocages, which may be microporous. A composition may include homostacks of layers of the same inorganic mesoporous materials. A composition may include heterostacks of layers of inorganic mesoporous materials, where at least two of the layers are different. The compositions may be surface functionalized. The compositions may be formed in a reaction mixture including one or more precursor(s), one or more surfactant(s), water, and one or more organic solvent(s). The compositions may be formed at the liquid-liquid interface between the water and the one or more organic solvent(s). A composition may be used as a catalyst, in a catalytic method, as a separation medium, in a separation method, in nanomedicine applications, or the like.

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