公开(公告)号：US20240360397A1

公开(公告)日：2024-10-31

申请号：US18647679

申请日：2024-04-26

Applicant: CORNING INCORPORATED

Inventor： Ye Fang ,  Anthony Glenn Frutos ,  Vasiliy Nikolaevich Goral ,  Joel Andrew Schultes ,  Elena Ravilievna Streltsova ,  Todd Michael Upton ,  Jennifer Lynn Weber

IPC: C12M1/12 ,  C12M1/00 ,  C12M1/34

CPC classification number: C12M25/18 ,  C12M29/04 ,  C12M41/36

Abstract: A cell culture bioreactor is disclosed that has a cell culture vessel with an interior reservoir to contain a cell substrate, an inlet fluidly connected to the reservoir, and an outlet fluidly connect to the reservoir. The bioreactor also has a sensor system for measuring impedance within the reservoir. The sensor system includes a pair of electrodes that are spaced apart from each other with at least a portion of the cell substrate disposed between the pair of electrodes. Each electrode of the pair of electrodes includes a plurality of pores to allow at least one of cells and culture media to flow through the electrode.