公开(公告)号：US20230347024A1

公开(公告)日：2023-11-02

申请号：US18303912

申请日：2023-04-20

申请人： CORTRONIK GmbH

发明人： Martin Thoebe ,  Angela Podssun-Soldan ,  Alexander Rzany ,  Carsten Momma ,  Heinz Mueller

IPC分类号： A61L31/04 ,  A61L31/16 ,  A61L31/00

CPC分类号： A61L31/044 ,  A61L31/005 ,  A61L31/16 ,  A61L2430/40

摘要： A method for producing a biological cover includes providing a first material having a main body in a cylindrical configuration with at least one fold in the first material. A second material is arranged within the at least one fold. The first material is a biological material. The first material with the arranged second material is pressed onto a counter member arranged outside the cylindrical configuration. A crosslinking agent is applied to the first material. A biological cover is formed of a biological material having a main body in a cylindrical configuration having a first cylinder diameter. There is at least one fold in the main body. The at least one fold is configured to at least partially unfold upon radial dilation of the biological material to permit enlargement of the cylindrical configuration to a second cylinder diameter.

公开(公告)号：US20230001056A1

公开(公告)日：2023-01-05

申请号：US17781084

申请日：2020-11-27

申请人： CORTRONIK GMBH

发明人： Stefan Oschatz ,  Sabine Illner ,  Jonathan Ortelt ,  Daniela Arbeiter ,  Michael Teske ,  Heinz Mueller ,  Niels Grabow ,  Carsten Momma ,  Klaus-Peter Schmitz

IPC分类号： A61L31/06 ,  D04H1/728 ,  D06M10/10

摘要： A material includes nonwoven fibers and a surface modification that crosslinks the nonwoven fibers together. The surface modification can include chemical reactive groups. The reactive groups can be selected from diisocyanates, alcohols, epoxides, imides, amides, imines, amines, diacrylates, disiloxanes and disilazanes. A method of forming the material electrospins fiber material in the form of fibers into a nonwoven material. A surface modification is introduced to the fibers either by modifying the fiber material before the electrospinning or by modifying the fiber surface after the electrospinning. The fibers are crosslinked to form the crosslinked nonwoven material.

公开(公告)号：US20230009211A1

公开(公告)日：2023-01-12

申请号：US17780144

申请日：2020-11-24

申请人： CORTRONIK GMBH

发明人： Stefanie Kohse ,  Kerstin Lebahn ,  Niels Grabow ,  Dalibor Bajer ,  Swen Grossmann ,  Klaus-Peter Schmitz ,  Heinz Mueller ,  Carsten Momma ,  Sabine Illner ,  Daniela Arbeiter ,  Thomas Eickner

IPC分类号： A61L31/02 ,  A61L31/10 ,  A61L31/14 ,  C08L67/04 ,  A61L31/16

摘要： An intraluminal endoprosthesis such as a stent has a metallic supporting structure and a sleeve surrounding the supporting structure. The sleeve can include fibres which are applied to an outer side of the supporting structure. The fibres each have a polymer core and a hydrogel casing connected thereto. The sleeve can also be formed from a fibre mixture of polymer and hydrogel fibres.

公开(公告)号：US20230372103A1

公开(公告)日：2023-11-23

申请号：US17918810

申请日：2021-04-09

申请人： CORTRONIK GmbH

发明人： Michael Stiehm ,  Wolfram Schmidt ,  Niels Grabow ,  Jonas Keiler ,  Maria Reumann ,  Andreas Wree ,  Andreas Hof ,  Heinz Mueller ,  Carsten Momma ,  Klaus-Peter Schmitz ,  Karsten Koop ,  Julia Schubert ,  Kerstin Lebahn ,  Sabine Illner ,  Sabine Kischkel ,  Jonathan Ortelt

IPC分类号： A61F2/24

CPC分类号： A61F2/2475 ,  A61F2230/0017

摘要： A venous valve prosthesis for transporting a flow of body fluid in a vessel in a predetermined direction includes
includes a hollow-cylindrical support structure. A skirt is connected to the support structure and forms a closed, circumferential jacket of the support structure. The prosthesis also includes a valve leaflet arrangement with a first valve leaflet and a second valve leaflet, each being connected to the skirt. A downstream edge of the first valve leaflet and a downstream edge of the second valve leaflet are opposite to each other and configured in such a manner that in a first state of the valve leaflet arrangement they form an opening for blood to flow through in the predetermined direction and in a second state of the valve leaflet arrangement the opening is closed and to prevent a backflow of blood in a direction opposite to the predetermined direction. A ratio of the inner diameter of the support structure to its length in the predetermined direction is at most 1.

公开(公告)号：US20230024499A1

公开(公告)日：2023-01-26

申请号：US17779490

申请日：2020-11-18

申请人： CORTRONIK GMBH

发明人： Stefanie Kohse ,  Kerstin Lebahn ,  Niels Grabow ,  Dalibor Bajer ,  Swen Grossmann ,  Klaus-Peter Schmitz ,  Heinz Mueller ,  Carsten Momma ,  Sabine Illner ,  Daniela Arbeiter ,  Thomas Eickner

IPC分类号： A61L31/14 ,  A61L31/02 ,  A61L31/10 ,  A61L31/06 ,  A61L31/16 ,  D01D5/00 ,  D01D5/34

摘要： An intraluminal endoprosthesis has a biodegradable metallic supporting structure and a biodegradable sleeve surrounding the supporting structure. The sleeve includes fibres applied to the outer side of the supporting structure. The sleeve can be formed from fibres that each have a polymer core and a hydrogel casing. The sleeve can the sleeve be formed from a fibre mixture of polymer fibres and hydrogel fibres.

公开(公告)号：US20220411966A1

公开(公告)日：2022-12-29

申请号：US17779535

申请日：2020-11-17

申请人： CORTRONIK GMBH

发明人： Stefanie Kohse ,  Kerstin Lebahn ,  Niels Grabow ,  Dalibor Bajer ,  Swen Grossmann ,  Klaus-Peter Schmitz ,  Heinz Mueller ,  Carsten Momma

IPC分类号： D01D11/06 ,  A61F2/90 ,  D01D5/00

摘要： A method for producing an intraluminal endoprosthesis. The method forms a sheath on a support structure of the endoprosthesis from polymer fibres. A polymer solution is dispensed from a nozzle by f electrospinning. The polymer solution includes at least one biodegradable polymer polymer and at least one additive. The additive is selected from the group consisting of: 1,3-dioxan-2-one, 1,4-dioxan-2-one, triethyl citrate, glycerol triacetate, n-butyryl tri-n-hexyl citrate, polyethylene glycol, L-α phosphatidylcholine.