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公开(公告)号:US20160060592A1
公开(公告)日:2016-03-03
申请号:US14934434
申请日:2015-11-06
申请人: CPSI Holdings, LLC
发明人: John G. BAUST , Joshua T. SMITH , Kimberly L. SANTUCCI , Kristi K. SNYDER , Anthony T. ROBILOTTO , Robert G. VAN BUSKIRK , John M. BAUST , William L. CORWIN , Jennie F. MCKAIN
CPC分类号: C12M21/08 , C12M25/06 , C12M25/14 , C12M27/00 , C12M29/00 , C12N5/0062 , C12N5/0068 , C12N5/0697 , C12N2537/00 , G01N33/5008 , G01N33/5017
摘要: A tissue engineered model (TEM) structure, an apparatus and method for making a TEM structure, and methods of using a TEM structure are disclosed. In an embodiment, the TEM structure includes at least one TEM segment. Each TEM segment includes a frame defining a bounded area, the frame having a height, a first edge, and a second edge opposite the first edge, each of the first edge and the second edge defining a perimeter of the bounded area, and the height defining a distance between the first edge and the second edge; a membrane affixed to the first edge about a perimeter of the frame; and a solidified gel and cell matrix disposed within the bounded area within the frame, wherein the solidified gel and cell matrix substantially fills a volume defined by the bounded area and the height of the frame.
摘要翻译: 公开了一种组织工程模型(TEM)结构,用于制造TEM结构的装置和方法,以及使用TEM结构的方法。 在一个实施例中,TEM结构包括至少一个TEM段。 每个TEM段包括限定有界区域的框架,框架具有高度,第一边缘和与第一边缘相对的第二边缘,第一边缘和第二边缘中的每一个限定有界区域的周边,并且高度 限定所述第一边缘和所述第二边缘之间的距离; 围绕所述框架的周边固定到所述第一边缘的膜; 以及设置在框架内的有界区域内的凝固凝胶和细胞基质,其中凝固的凝胶和细胞基质基本上填充由界限区域和框架的高度限定的体积。
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公开(公告)号:US20140273063A1
公开(公告)日:2014-09-18
申请号:US14206533
申请日:2014-03-12
申请人: CPSI HOLDINGS LLC
发明人: John G. BAUST , Joshua T. SMITH , Kimberly L. SANTUCCI , Kristi K. SNYDER , Anthony T. ROBILOTTO , Robert G. VAN BUSKIRK , John M. BAUST , William L. CORWIN , Jennie F. MCKAIN
IPC分类号: G01N33/50
CPC分类号: C12M21/08 , C12M25/06 , C12M25/14 , C12M27/00 , C12M29/00 , C12N5/0062 , C12N5/0068 , C12N5/0697 , C12N2537/00 , G01N33/5008 , G01N33/5017
摘要: A tissue engineered model (TEM) structure, an apparatus and method for making a TEM structure, and methods of using a TEM structure are disclosed. In an embodiment, the TEM structure includes at least one TEM segment. Each TEM segment includes a frame defining a bounded area, the frame having a height, a first edge, and a second edge opposite the first edge, each of the first edge and the second edge defining a perimeter of the bounded area, and the height defining a distance between the first edge and the second edge; a membrane affixed to the first edge about a perimeter of the frame; and a solidified gel and cell matrix disposed within the bounded area within the frame, wherein the solidified gel and cell matrix substantially fills a volume defined by the bounded area and the height of the frame.
摘要翻译: 公开了一种组织工程模型(TEM)结构,用于制造TEM结构的装置和方法,以及使用TEM结构的方法。 在一个实施例中,TEM结构包括至少一个TEM段。 每个TEM段包括限定有界区域的框架,框架具有高度,第一边缘和与第一边缘相对的第二边缘,第一边缘和第二边缘中的每一个限定有界区域的周边,并且高度 限定所述第一边缘和所述第二边缘之间的距离; 围绕所述框架的周边固定到所述第一边缘的膜; 以及设置在框架内的有界区域内的凝固凝胶和细胞基质,其中凝固的凝胶和细胞基质基本上填充由界限区域和框架的高度限定的体积。
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公开(公告)号:US20170191011A1
公开(公告)日:2017-07-06
申请号:US15463448
申请日:2017-03-20
申请人: CPSI Holdings, LLC
发明人: John G. BAUST , Joshua T. SMITH , Kimberly L. SANTUCCI , Kristi K. SNYDER , Anthony T. ROBILOTTO , Robert G. VAN BUSKIRK , John M. BAUST , William L. CORWIN , Jennie F. MCKAIN
CPC分类号: C12M21/08 , C12M25/06 , C12M25/14 , C12M27/00 , C12M29/00 , C12N5/0062 , C12N5/0068 , C12N5/0697 , C12N2537/00 , G01N33/5008 , G01N33/5017
摘要: A tissue engineered model (TEM) structure, an apparatus and method for making a TEM structure, and methods of using a TEM structure are disclosed. In an embodiment, the TEM structure includes at least one TEM segment. Each TEM segment includes a frame defining a bounded area, the frame having a height, a first edge, and a second edge opposite the first edge, each of the first edge and the second edge defining a perimeter of the bounded area, and the height defining a distance between the first edge and the second edge; a membrane affixed to the first edge about a perimeter of the frame; and a solidified gel and cell matrix disposed within the bounded area within the frame, wherein the solidified gel and cell matrix substantially fills a volume defined by the bounded area and the height of the frame.
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