公开(公告)号：US20180030026A1

公开(公告)日：2018-02-01

申请号：US15724596

申请日：2017-10-04

申请人： CURADEV PHARMA PRIVATE LTD.

发明人： Monali Banerjee ,  Sandip Middya ,  Ritesh Shrivastava ,  Sushil Raina ,  Arjun Surya ,  Dharmendra B. Yadav ,  Veejendra K. Yadav ,  Kamal Kishore Kapoor ,  Aranapakam Venkatesan ,  Roger A. Smith ,  Scott K. Thompson

IPC分类号： C07D333/66 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/704 ,  A61K31/381 ,  C07D409/12 ,  A61K31/4436 ,  C07D491/048 ,  C12Q1/26 ,  C07D307/82 ,  C07D495/04 ,  C07D491/04 ,  A61K31/343 ,  C07D409/04

CPC分类号： C07D333/66 ,  A61K31/343 ,  A61K31/381 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/704 ,  C07D307/82 ,  C07D409/04 ,  C07D409/12 ,  C07D491/04 ,  C07D491/048 ,  C07D495/04 ,  C12Q1/26 ,  G01N2333/90241 ,  Y02A50/411

摘要： The present application provides novel inhibitors of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase, metabolites thereof, and pharmaceutically acceptable salts or prodrugs thereof. Also provided are methods for preparing these compounds. A therapeutically effective amount of one or more of the compounds of formula (I) is useful in treating diseases resulting from dysregulation of the kynurenine pathway. Compounds of formula (I) act by inhibiting the enzymatic activity or expression of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxy-genase.

公开(公告)号：US20160046596A1

公开(公告)日：2016-02-18

申请号：US14774383

申请日：2014-03-12

申请人： CURADEV PHARMA PRIVATE LTD.

发明人： Monali Banerjee ,  Sandip Middya ,  Ritesh Shrivastava ,  Sushil Raina ,  Arjun Surya ,  Dharmendra B. Yadav ,  Veejendra K. Yadav ,  Kamal Kishore Kapoor ,  Aranapakam Venkatesan ,  Roger A. Smith ,  Scott K. Thompson

IPC分类号： C07D333/66 ,  A61K31/4355 ,  A61K31/704 ,  A61K31/444 ,  C07D307/82 ,  A61K31/343 ,  C07D495/04 ,  A61K31/4365 ,  A61K31/381 ,  C07D409/04 ,  A61K31/4436 ,  A61K31/5377 ,  A61K31/4545 ,  C07D409/12 ,  C12Q1/26 ,  C07D491/048

CPC分类号： C07D333/66 ,  A61K31/343 ,  A61K31/381 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/704 ,  C07D307/82 ,  C07D409/04 ,  C07D409/12 ,  C07D491/04 ,  C07D491/048 ,  C07D495/04 ,  C12Q1/26 ,  G01N2333/90241 ,  Y02A50/411

摘要： The present application provides novel inhibitors of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase, metabolites thereof, and pharmaceutically acceptable salts or prodrugs thereof. Also provided are methods for preparing these compounds. A therapeutically effective amount of one or more of the compounds of formula (I) is useful in treating diseases resulting from dysregulation of the kynurenine pathway. Compounds of formula (I) act by inhibiting the enzymatic activity or expression of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase.

摘要翻译： 本申请提供吲哚胺2,3-双加氧酶-1和/或吲哚胺2,3-双加氧酶-2和/或色氨酸2,3-双加氧酶及其药学上可接受的盐或前药的新型抑制剂。 还提供了制备这些化合物的方法。 治疗有效量的一种或多种式（I）化合物可用于治疗由犬尿氨酸途径失调引起的疾病。 式（I）化合物通过抑制吲哚胺2,3-双加氧酶-1和/或吲哚胺2,3-双加氧酶-2和/或色氨酸2,3-双加氧酶的酶活性或表达而起作用。

公开(公告)号：US09815811B2

公开(公告)日：2017-11-14

申请号：US14774383

申请日：2014-03-12

申请人： CURADEV PHARMA PRIVATE LTD.

发明人： Monali Banerjee ,  Sandip Middya ,  Ritesh Shrivastava ,  Sushil Raina ,  Arjun Surya ,  Dharmendra B. Yadav ,  Veejendra K. Yadav ,  Kamal Kishore Kapoor ,  Aranapakam Venkatesan ,  Roger A. Smith ,  Scott K. Thompson

IPC分类号： C07D491/048 ,  C07D333/66 ,  C07D307/82 ,  C07D491/04 ,  C07D495/04 ,  A61K31/343 ,  A61K31/381 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/704 ,  C07D409/04 ,  C07D409/12 ,  C12Q1/26

CPC分类号： C07D333/66 ,  A61K31/343 ,  A61K31/381 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/704 ,  C07D307/82 ,  C07D409/04 ,  C07D409/12 ,  C07D491/04 ,  C07D491/048 ,  C07D495/04 ,  C12Q1/26 ,  G01N2333/90241 ,  Y02A50/411

摘要： The present application provides novel inhibitors of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase, metabolites thereof, and pharmaceutically acceptable salts or prodrugs thereof. Also provided are methods for preparing these compounds. A therapeutically effective amount of one or more of the compounds of formula (I) is useful in treating diseases resulting from dysregulation of the kynurenine pathway. Compounds of formula (I) act by inhibiting the enzymatic activity or expression of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase.

公开(公告)号：US10294212B2

公开(公告)日：2019-05-21

申请号：US15724596

申请日：2017-10-04

申请人： CURADEV PHARMA PRIVATE LTD.

发明人： Monali Banerjee ,  Sandip Middya ,  Ritesh Shrivastava ,  Sushil Raina ,  Arjun Surya ,  Dharmendra B. Yadav ,  Veejendra K. Yadav ,  Kamal Kishore Kapoor ,  Aranapakam Venkatesan ,  Roger A. Smith ,  Scott K. Thompson

IPC分类号： C07D333/66 ,  C07D307/82 ,  C07D491/04 ,  C07D495/04 ,  A61K31/343 ,  A61K31/381 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/704 ,  C07D409/04 ,  C07D409/12 ,  C07D491/048 ,  C12Q1/26

摘要： The present application provides novel inhibitors of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase, metabolites thereof, and pharmaceutically acceptable salts or prodrugs thereof. Also provided are methods for preparing these compounds. A therapeutically effective amount of one or more of the compounds of formula (I) is useful in treating diseases resulting from dysregulation of the kynurenine pathway. Compounds of formula (I) act by inhibiting the enzymatic activity or expression of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxy-genase.