公开(公告)号：US20240076605A1

公开(公告)日：2024-03-07

申请号：US18272249

申请日：2022-02-01

Applicant: CYTIVA SWEDEN AB

Inventor： ANDREAS AXÉN ,  HELENA VESTERBERG ,  MAGNUS WETTERHALL ,  CAMILLA ESTMER NILSSON

IPC: C12M1/36 ,  C12M1/00 ,  C12M1/34

CPC classification number: C12M41/48 ,  C12M29/10 ,  C12M29/24 ,  C12M41/12 ,  C12M41/26 ,  C12M41/30 ,  C12M41/46 ,  C12M47/10

Abstract: The present invention relates to a method for controlling process parameters in a bioreactor when producing a target product with a pre-determined critical to quality, CTQ, profile. The method comprises: monitoring (S20) at least one product quality attribute, PQA, for the target product; identifying (S30) trends and/or deviations by comparing the monitored at least one PQA to the CTQ profile of the target product; and controlling (S40) process parameters of the bioreactor based on the identified trends and/or deviations to maintain the target product within the CTQ profile.