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1.发明申请公开(公告)号：US20220404321A1
公开(公告)日：2022-12-22
申请号：US17772902
申请日：2020-11-17
申请人： Cytiva Sweden AB
发明人： Nils Stafstrom
摘要： Disclosed is a method for determining an operating flow rate for a chromatographic column (4) in an HPLC system (1). The method comprises: measuring/calculating a pressure of the system (1) without the chromatographic column (4) for one or more flow rates; fitting a function to the flow rate(s) and corresponding pressure(s), calculating from the function and a predetermined recommended flow rate for the chromatographic column (4) a system pressure drop at the predetermined recommended flow rate. An operating flow rate is determined by summing the system pressure drop and a maximal column pressure limit, and determining a contribution of the system pressure drop to the summed pressure. If this contribution exceeds 1% an operating flow rate for the column is determined to a flow rate that corresponds to a pressure at a pressure monitor arranged before the column that is lower than the predetermined maximum column pressure limit.
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公开(公告)号：US20230068163A1
公开(公告)日：2023-03-02
申请号：US17938303
申请日：2022-10-05
申请人： CYTIVA SWEDEN AB
摘要： The present invention relates to a nozzle for an air trapping device configured to remove air from a fluid, the nozzle comprising a body having an input opening configured to receive the fluid and an output opening configured to distribute the fluid along an edge of the output opening, wherein the edge comprises a control element configured to reduce surface tension of the fluid. The present invention further relates to an air trapping device configured to remove air from a fluid and comprising the nozzle.
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公开(公告)号：US20220001300A1
公开(公告)日：2022-01-06
申请号：US17280425
申请日：2019-10-09
申请人： Cytiva Sweden AB
发明人： Nils Stafstrom
摘要： A method for fraction collection and a fraction collection system (100) comprising: —a dispensing device (23) including an outlet (24) configured for dispensing fractions of a liquid received from a connected system; —plural receptacles (25) configured for receiving one or more of said fractions, wherein the receptacles (25) and the dispensing device (23) are movable in relation to each other into a number of different positions such that the dispensing device (23) is capable of dispensing a respective fraction of said liquid into one or more of the receptacles (25); —a waste collection device (27), which is arranged in the fraction collection system (100) such that it is movable into at least a first and a second position wherein, in said first position, an inlet (29) of the waste collection device (27) is positioned below the outlet (24) of the dispensing device (23) such that liquid being dispensed from the outlet (24) of the dispensing device (23) is received in the waste collection device (27) and wherein, in the second position, the inlet (29) of the waste collection device (27) is not positioned below the outlet (24) of the dispensing device (23) such that fractions being dispensed from the dispensing device (23) can be received in one or more of the receptacles (25).
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公开(公告)号：US11237130B2
公开(公告)日：2022-02-01
申请号：US15738361
申请日：2016-06-30
申请人： Cytiva Sweden AB
发明人： Lennart Bjorkesten , Nils Stafstrom
IPC分类号： G01N27/447 , G01N30/86 , G01N21/64 , G06F17/15
摘要： The present invention relates to a method for determining size of biomolecules separated in a medium by an electric field using marker molecules of known size, comprising —(101) detecting a plurality of bands and forming a detected marker sequence and a detected unknown sequence based on a separation criterion, —(102) determining band properties for each detected band, —(103) comparing the band properties of the detected bands of the detected marker sequence with known band properties for a plurality of marker molecules forming a known marker sequence and assigning a score to each comparison, said score being based on at least one of relative distance, relative intensity, expected distance and expected intensity between bands, —(104) selecting the comparison with the highest score and associating all or a subset of the detected bands of the detected marker sequence with said plurality of marker molecules of the known marker sequence in accordance with said comparison to determine size of the all or a subset of the detected marker sequence, and —(105) comparing the bands of the detected marker sequence with the bands of the detected unknown sequence to determine a size of biomolecules for each identified band of the detected unknown sequence based on the known sizes of the marker molecules. The invention also relates to software configured to perform the method and to a computer readable medium for storing said software.
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