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公开(公告)号：US20220033750A1
公开(公告)日：2022-02-03
申请号：US17296726
申请日：2019-12-10
Applicant: Cytiva Sweden AB
Inventor： Andreas Lundin , Bjorn Olovsson , Klaus Gebauer , Tim Francois , Kerstin Erickson
Abstract: A flow distribution device for bioprocess systems, comprising: a flow distribution manifold (12; 112) comprising: at least four fluid connection conduits (14), wherein each fluid connection conduit (14) comprises a first end (18) for fluid connection and an opposite second end (20), and wherein at least three of the fluid connection conduits comprise a membrane (19a) and a valve seat (19b), which membrane (19a) can be put in at least two different positions in relation to the valve seat (19b) for allowing or preventing fluid flow between the first end (18) and the second end (20) of the fluid connection conduit (14); and a central common compartment (30) to which the second ends (20) of each of the fluid connection conduits (14) are connected, whereby the first ends (18) of each of the fluid connection conduits (14) can be in fluid communication with the central common compartment (30) and wherein the fluid connection conduits (14) are entering the central common compartment (30) from at least three different directions; wherein said flow distribution device (10) further comprises at least three membrane actuation members (41) which are provided in connection with one membrane (19a) of the flow distribution manifold (12; 112) each, wherein each of said membrane actuation members (41) is configured for actuating the membrane (19a) to be in at least two different positions in relation to the valve seat (19b), wherein a first position of the membrane (19a) allows flow between the first end (18) and the second end (20) of the fluid connection conduit (14) and a second position of the membrane (19a) prevents flow between the first end (18) and the second end (20) of the fluid connection conduit (14).
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公开(公告)号：US11547956B2
公开(公告)日：2023-01-10
申请号：US16622524
申请日：2018-06-28
Applicant: Cytiva Sweden AB
Inventor： Mats Lundkvist , Bjorn A. Johansson , Tim Francois
IPC: B01D15/22 , F16L37/138 , F16L37/56 , G01N30/60 , G01N30/02
Abstract: Disclosed are chromatography systems employing a releasable coupling (100) for holding a fluid tubing to a spigot, the coupling comprising: a cylindrical inner component (110) for accepting a fluid tubing (30), said inner component including a resiliently deflectable portion (118) arranged to urge an outer surface of the tubing toward a spigot; and a cylindrical collar (130) having and internal through-aperture (132) for slideably accepting the inner component, the aperture and resilient portion having complementary surface formations which in a first position of the collar mounted to the inner component provide for said resilient deflection in use, and which in a second different position do not cause said deflection, the coupling being characterized in that the collar comprises a collar flange (134) extending outwardly away from the aperture of a size allowing manual manipulation of the collar between the first and second positions. Chromatography systems employing said couplings is disclosed also.
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Patent Agency Ranking
公开(公告)号：US20230349867A1
公开(公告)日：2023-11-02
申请号：US18350588
申请日：2023-07-11
Applicant: Cytiva Sweden AB
Inventor： Nils Stafstrom , Lars Olof Nils Rosengren , Kerstin Elisabet Erickson , Tomas Yngve Agren , Yngve L. Hareland , Tim Francois , Anita Jonsson , Jeanne Cheng , Anna Andersson
CPC classification number: G01N30/44 , G01N30/32 , G01N30/46 , G01N30/6052 , G01N30/8696 , G01N2030/326
Abstract: Disclosed is a chromatography system (100) comprising: plural modules (1-25) including at least one pump and a column valve unit (8) connectable to plural chromatography columns; and a controller (600), the controller being operable to control the or each pump and the column valve to perform different chromatographic processes, including chromatography employing just one column, as well as chromatography employing just one column, as well as chromatography employing two or more columns by selective valve opening in said unit. The system includes a housing (110) into which the plural modules (1-25) are interchangeably mountable in apertures of one generally vertical face of housing, the modules are adapted for selective fluidic interconnection by tubing substantially at said one face such that in use the modules and tubing occupy a generally vertically extending volume to minimize the footprint of the system.
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公开(公告)号：US20220025313A1
公开(公告)日：2022-01-27
申请号：US17296711
申请日：2019-12-10
Applicant: Cytiva Sweden AB
Inventor： Bjorn Olovsson , Andreas Lundin , Klaus Gebauer , Tim Francois , Kerstin Erickson
IPC: C12M1/00
Abstract: A flow distribution device for bioprocess systems, comprising: ⋅—a flow distribution manifold (12; 112; 212; 312) comprising: ⋅o at least four fluid connection tubes (14), wherein each fluid connection tube (14) comprises a first end (18) for fluid connection and an opposite second end (20) ⋅o a central common compartment (30; 130; 230; 330) to which the second ends (20) of each of the fluid connection tubes (14) are connected, whereby the first ends (18) of each of the fluid connection tubes (14) can be in fluid communication with the central common compartment (30; 130; 230; 330) ⋅—at least three pinching members (41) which are provided in connection with one fluid connection tube (14) of the flow distribution manifold (12; 112; 212; 312) each, wherein each of said pinching members (41) can be controlled into at least a first and a second position, wherein in the first position for each of the pinching members (41) the pinching member pinches one of the fluid connection tubes (14) such that fluid flow is prevented between the first end (18) and the second end (20) of this fluid connection tube (14)
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公开(公告)号：US20240150697A1
公开(公告)日：2024-05-09
申请号：US18550075
申请日：2022-04-25
Applicant: CYTIVA SWEDEN AB
Inventor： Klaus Gebauer , Tim Francois , Andreas Lundin , Bjorn Markus Olovsson , Kerstin Erickson , Tomas Dalmo
Abstract: The present invention relates to a reconfigurable bioprocessing system (80) operable to perform a predetermined set of bioprocessing operations therein. The reconfigurable bioprocessing system (80) comprises a base unit (60) comprising a plurality of valve actuators (102). At least one of the plurality of valve actuators (102) is operable to releasably engage with at least part of a pinch valve cassette (103, 203) to control fluid flow through the pinch valve cassette (103, 203). At least part of the pinch valve cassette (103, 203) is removably attachable to the base unit (60) and the pinch valve cassette (103, 203) is provided adjacent to said plurality of valve actuators (102). The reconfigurable bioprocessing system (80) also includes a control system operable to selectively actuate respective of said plurality of valve actuators (102) to provide a valve configuration within the pinch valve cassette (103, 203) to enable the base unit (60) and the pinch valve cassette (103, 203) together to perform one of the predetermined set of bioprocessing operations. A flow kit (107) for use in reconfigurable bioprocessing systems (80) and various methods (1000) for reconfiguring bioprocessing systems (80) (e.g. automatically) are also disclosed.
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公开(公告)号：US20230304974A1
公开(公告)日：2023-09-28
申请号：US18326838
申请日：2023-05-31
Applicant: Cytiva Sweden AB
Inventor： Lars Olof Nils Rosengren , Kerstin Elisabet Erickson , Tim Francois
CPC classification number: G01N30/20 , G01N30/468 , G01N2030/201 , G01N2030/205 , B01D15/1821
Abstract: The present invention relates to a valve unit for a chromatography apparatus, the valve unit comprising a fluid inlet configured to receive an input fluid, a fluid outlet configured to provide an output fluid, a first pair of fluid ports configured to be coupled to a first column, a second pair of fluid ports configured to be coupled to a second column, a coupling valve assembly configured to direct fluid between a selection of the fluid inlet, the fluid outlet, the first pair of fluid ports and the second pair of fluid ports in response to one or more control signals, wherein the coupling valve assembly is configured to direct fluid using a selection of membrane valves coupled by fluid channels comprised in a body of the coupling valve assembly. The invention further relates to a chromatography apparatus comprising the valve unit and a membrane valve comprised in the valve unit.
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公开(公告)号：US20230102761A1
公开(公告)日：2023-03-30
申请号：US18047190
申请日：2022-10-17
Applicant: Cytiva Sweden AB
Inventor： Mats Lundkvist , Bjorn A. Johansson , Tim Francois
Abstract: Disclosed are chromatography systems employing a releasable coupling 100 for holding a fluid tubing to a spigot, the coupling comprising: a cylindrical inner component 110 for accepting a fluid tubing 30, said inner component including a resiliently deflectable portion 118 arranged to urge an outer surface of the tubing toward a spigot; and a cylindrical collar 130 having and internal through-aperture 132 for slideably accepting the inner component, the aperture and resilient portion having complementary surface formations which in a first position of the collar mounted to the inner component provide for said resilient deflection in use, and which in a second different position do not cause said deflection, the coupling being characterized in that the collar comprises a collar flange 134 extending outwardly away from the aperture of a size allowing manual manipulation of the collar between the first and second positions. Chromatography systems employing said couplings is disclosed also.
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