公开(公告)号：US11229809B2

公开(公告)日：2022-01-25

申请号：US15912359

申请日：2018-03-05

Applicant: California Institute of Technology

Inventor： David Reza Mittelstein ,  Morteza Gharib ,  Stefanie Heyden ,  Michael Ortiz ,  Mikhail G. Shapiro

IPC: A61N7/00 ,  A61M37/00 ,  A61B8/08 ,  A61B17/3205 ,  A61B5/055 ,  A61B18/00 ,  A61B90/00 ,  A61B17/00

Abstract: Systems and methods for targeting specific cell types by selective application of ultrasonic harmonic excitation at a resonance frequency (“oncotripsy”) for the specific cell types are presented. The systems and the methods result in permeabilization, lysis, and/or death of the targeted specific cell types by using ultrasonic harmonic excitations that have a frequency and a pulse duration specifically tuned to disrupt nuclear membranes of the targeted specific cell types by inducing a destructive vibrational response therein while leaving non-targeted cell types intact. Target cells may be neoplastic.

公开(公告)号：US20180256922A1

公开(公告)日：2018-09-13

申请号：US15912359

申请日：2018-03-05

Applicant: California Institute of Technology

Inventor： David Reza Mittelstein ,  Morteza Gharib ,  Stefanie Heyden ,  Michael Ortiz ,  Mikhail G. Shapiro

IPC: A61N7/00 ,  A61M37/00

CPC classification number: A61N7/00 ,  A61B5/055 ,  A61B8/485 ,  A61B8/5261 ,  A61B17/3205 ,  A61B2017/00154 ,  A61B2018/00642 ,  A61B2018/0066 ,  A61B2018/00732 ,  A61B2090/374 ,  A61B2090/378 ,  A61M37/0092

Abstract: Systems and methods for targeting specific cell types by selective application of ultrasonic harmonic excitation at their resonance frequency (“oncotripsy”) are presented. The systems and methods result in the permeabilization, lysis, and/or death of targeted cell types by using ultrasonic harmonic excitations that have their frequency and pulse duration specifically tuned to disrupt the nuclear membrane of the targeted cells types by inducing a destructive vibrational response therein while leaving non-targeted cell types intact. Target cells may be neoplastic.