公开(公告)号：US11078480B2

公开(公告)日：2021-08-03

申请号：US16575124

申请日：2019-09-18

Applicant: California Institute of Technology

Inventor： Mitchell Guttman ,  Sofia A. Quinodoz ,  Mario R. Blanco ,  Devdoot Majumdar

IPC: C12N15/10 ,  G01N33/53 ,  G01N33/68

Abstract: Methods of detecting an interaction between a macromolecule and an interaction partner are described. Kits are also described.

公开(公告)号：US20200087657A1

公开(公告)日：2020-03-19

申请号：US16575124

申请日：2019-09-18

Applicant: California Institute of Technology

Inventor： Mitchell Guttman ,  Sofia A. Quinodoz ,  Mario R. Blanco ,  Devdoot Majumdar

IPC: C12N15/10 ,  G01N33/68 ,  G01N33/53

Abstract: Methods of detecting an interaction between a macromolecule and an interaction partner are described. Kits are also described.

公开(公告)号：US20200088729A1

公开(公告)日：2020-03-19

申请号：US16573673

申请日：2019-09-17

Applicant: California Institute of Technology

Inventor： Mitchell Guttman ,  Mario R. Blanco

IPC: G01N33/573 ,  C12N15/90

Abstract: In some embodiments, methods of detecting an association between a query protein and a target moiety are described. In some embodiments, compositions are described. In some embodiments, kits are described.

公开(公告)号：US20240125783A1

公开(公告)日：2024-04-18

申请号：US18491255

申请日：2023-10-20

Applicant: California Institute of Technology

Inventor： Mitchell Guttman ,  Mario R. Blanco ,  Ward Walkup, IV

IPC: G01N33/573 ,  C12N15/90

CPC classification number: G01N33/573 ,  C12N15/907 ,  C12Y201/01043

Abstract: In some embodiments, methods of detecting an association between a query protein and a target moiety are described. In some embodiments, compositions are described. In some embodiments, kits are described.

公开(公告)号：US20230408504A1

公开(公告)日：2023-12-21

申请号：US18167362

申请日：2023-02-10

Applicant: California Institute of Technology

Inventor： Mitchell Guttman ,  Andrew A. Perez ,  Mario R. Blanco ,  Isabel N. Goronzy ,  James K. Guo

IPC: G01N33/543

CPC classification number: G01N33/54353 ,  G01N33/54326 ,  G01N33/54346

Abstract: Disclosed herein include methods, compositions, and kits suitable for use in generating barcoded detection particles. Each barcoded detection particle can comprise a particle associated with an antigen-binding protein and a plurality of barcoding oligonucleotides. The plurality of barcoding oligonucleotides can comprise a first ligand. The particle can comprise a second ligand. The plurality of barcoding oligonucleotides can be associated with the particle via a multivalent binding agent comprising two or more binding moieties capable of binding the first ligand and/or the second ligand. There are provided, in some embodiments, methods for detecting interactions between nucleic acid molecules and proteins of interest. Methods for detecting interactions between ribonucleic acid molecules and RNA-binding proteins (RBPs) are also provided herein.

公开(公告)号：US11828684B2

公开(公告)日：2023-11-28

申请号：US16573673

申请日：2019-09-17

Applicant: California Institute of Technology

Inventor： Mitchell Guttman ,  Mario R. Blanco ,  Ward Walkup, IV

IPC: G01N33/573 ,  C12N15/90

CPC classification number: G01N33/573 ,  C12N15/907 ,  C12Y201/01043

Abstract: In some embodiments, methods of detecting an association between a query protein and a target moiety are described. In some embodiments, compositions are described. In some embodiments, kits are described.