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公开(公告)号：US12129272B2
公开(公告)日：2024-10-29
申请号：US18104297
申请日：2023-02-01
Inventor： William M. Clemons , Michio Kurosu
IPC: C07H19/06 , A61K31/337 , A61K31/7072 , C07H1/00
CPC classification number: C07H19/06 , C07H1/00 , A61K31/337 , A61K31/7072
Abstract: The present invention relates to methods of treating bacterial infections and cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of at least one compound provided herein.
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2.发明公开公开(公告)号：US20230340006A1
公开(公告)日：2023-10-26
申请号：US18013403
申请日：2021-06-30
Inventor： Michio KUROSU , Katsuhiko MITACHI , William M. Clemons
IPC: C07H19/067 , A61K45/06
CPC classification number: C07H19/067 , A61K45/06
Abstract: Provided herein are compounds and methods of using these compounds to treat disorders related to DPAGT1 function, including cancer and bacterial infections.
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公开(公告)号：US20250092081A1
公开(公告)日：2025-03-20
申请号：US18903537
申请日：2024-10-01
Inventor： William M. Clemons , Michio Kurosu
IPC: C07H19/06 , A61K31/337 , A61K31/7072 , C07H1/00
Abstract: The present invention relates to methods of treating breast cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of at least one compound provided herein. In some embodiments the subject can be receiving chemotherapy with a conventional chemotherapy drug and/or a therapeutic monoclonal antibody or drug conjugate thereof.
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Patent Agency Ranking
4.发明授权公开(公告)号：US11545236B2
公开(公告)日：2023-01-03
申请号：US15444247
申请日：2017-02-27
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Shyam M. Saladi , William M. Clemons
Abstract: Membrane protein expression can be predicted using statistical frameworks to provide an enhanced subset of sequences, out of an initial larger set of potentially expressing sequences, by using features derived from sequences and a model parameterized through a dataset of known expression levels. Also, membrane protein experimentation protocols can be designed using the statistical frameworks in concert known outcomes to identify which laboratory conditions are most likely to produce successful results.
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公开(公告)号：US20240199677A1
公开(公告)日：2024-06-20
申请号：US18104297
申请日：2023-02-01
Inventor： William M. Clemons , Michio Kurosu
CPC classification number: C07H19/06 , C07H1/00 , A61K31/337
Abstract: The present invention relates to methods of treating bacterial infections and cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of at least one compound provided herein.
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公开(公告)号：US11597743B2
公开(公告)日：2023-03-07
申请号：US16960608
申请日：2019-01-11
Inventor： William M. Clemons , Michio Kurosu
IPC: C07H19/06 , A61K31/7072 , C07H1/00 , A61K31/337
Abstract: The present invention relates to methods of treating bacterial infections and cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula I. Also provided are methods of inhibiting dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of a compound of Formula I:
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7.发明授权公开(公告)号：US09541558B2
公开(公告)日：2017-01-10
申请号：US14017744
申请日：2013-09-04
Applicant: California Institute of Technology
Inventor： William M. Clemons , Kyoung-Soon Jang , Roger Nani , Sergiy Levin , Sarah Reisman
IPC: G01N33/68
CPC classification number: G01N33/6848 , G01N33/6842 , Y10T436/143333
Abstract: A cysteine hydrazide nicotinamide (Cyhn) reagent designed for the enrichment of bacterial glycoproteins is provided. Methods for purification of free oligosaccharides and their analysis are also provided.
Abstract translation: 提供了设计用于富集细菌糖蛋白的半胱氨酸酰肼烟酰胺（Cyhn）试剂。 还提供了纯化游离寡糖的方法及其分析。
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公开(公告)号：US20140072981A1
公开(公告)日：2014-03-13
申请号：US14017744
申请日：2013-09-04
Applicant: California Institute of Technology
Inventor： William M. Clemons , Kyoung-Soon Jang , Roger Nani , Sergiy Levin , Sarah Reisman
IPC: G01N33/68
CPC classification number: G01N33/6848 , G01N33/6842 , Y10T436/143333
Abstract: A cysteine hydrazide nicotinamide (Cyhn) reagent designed for the enrichment of bacterial glycoproteins is provided. Methods for purification of free oligosaccharides and their analysis are also provided.
Abstract translation: 提供了设计用于富集细菌糖蛋白的半胱氨酸酰肼烟酰胺（Cyhn）试剂。 还提供了纯化游离寡糖的方法及其分析。
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