公开(公告)号：US20210052632A1

公开(公告)日：2021-02-25

申请号：US16959519

申请日：2019-01-16

Applicant: Cambridge Enterprise Limited

Inventor： Melinda DUER ,  David REID ,  Uliana BASHTANOVA

IPC: A61K31/7135 ,  A61K31/28

Abstract: The disclosure provides a selective inhibitor of DNA-binding to poly (ADP-ribose) polymerase 1 (PARP1), or a pharmaceutically acceptable salt or solvate thereof, for use in treating, ameliorating or preventing cancer. The treatment may be given to a subject suffering from or at risk of osteoporosis or a subject requiring a long-term therapy.

公开(公告)号：US20230116113A1

公开(公告)日：2023-04-13

申请号：US17799320

申请日：2021-02-12

Applicant: CAMBRIDGE ENTERPRISE LIMITED

Inventor： Melinda Jane DUER ,  Uliana BASHTANOVA ,  Rakesh RAJAN

IPC: A61K31/352 ,  A61K31/11 ,  A61K31/525 ,  A61K31/5415 ,  A61K31/132 ,  A61K31/728 ,  A61K41/00 ,  A61P35/00

Abstract: The present invention relates to the field of cancer progression. The invention provides in vivo methods for preventing or inhibiting the migration of cancer cells away from the site of a tumour or a resected tumour, thus inhibiting invasion and metastasis, by contacting all or part of the tumour or resected tumour, or all or part of the vicinity of the tumour, with an agent which impedes the migration and/or proliferation of cancer cells, such as a cross-linking agent.

公开(公告)号：US20240335397A1

公开(公告)日：2024-10-10

申请号：US18682559

申请日：2022-08-10

Applicant: CAMBRIDGE ENTERPRISE LIMITED

Inventor： Melinda Jane DUER ,  Uliana BASHTANOVA

IPC: A61K31/132 ,  A61K31/722 ,  A61K31/785 ,  A61P35/00

CPC classification number: A61K31/132 ,  A61K31/722 ,  A61K31/785 ,  A61P35/00

Abstract: The present invention relates to the field of brain tumour treatment. The invention provides methods of killing brain tumour cells in these tissues using high concentrations of cytotoxic agents which are capable of binding strongly to normal brain extracellular matrix (ECM), but less strongly to extracellular matrix components in the tumour environment. The cytotoxic agent is a polyamine, e.g. spermidine or putrescine.