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1.发明申请公开(公告)号：US20060193854A1
公开(公告)日：2006-08-31
申请号：US11429361
申请日：2006-05-05
申请人： Camellia Adams , Leonard Presta , Mark Sliwkowski
发明人： Camellia Adams , Leonard Presta , Mark Sliwkowski
IPC分类号： A61K39/395 , A61K31/525 , A61K31/7072 , A61K31/282 , A61K31/337 , A61K33/24
CPC分类号： A61K31/282 , A61K31/337 , A61K31/525 , A61K31/7072 , A61K33/24 , A61K39/395 , A61K45/06 , A61K47/6809 , A61K2039/505 , C07K16/32 , C07K2317/24 , C07K2317/55 , C07K2317/73 , C07K2317/76 , Y10S424/80 , Y10S424/801 , A61K2300/00
摘要： The present application describes humanized anti-ErbB2 antibodies and methods for treating cancer with anti-ErbB2 antibodies, such as humanized anti-ErbB2 antibodies.
摘要翻译： 本申请描述了人源化抗ErbB2抗体和用抗ErbB2抗体如人源化抗ErbB2抗体治疗癌症的方法。
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公开(公告)号：US20060198843A1
公开(公告)日：2006-09-07
申请号：US11429043
申请日：2006-05-05
申请人： Camellia Adams , Leonard Presta , Mark Sliwkowski
发明人： Camellia Adams , Leonard Presta , Mark Sliwkowski
IPC分类号： A61K39/395 , A61K31/7072 , A61K31/337 , A61K31/282 , A61K33/24
CPC分类号： A61K31/282 , A61K31/337 , A61K31/525 , A61K31/7072 , A61K33/24 , A61K39/395 , A61K45/06 , A61K47/6809 , A61K2039/505 , C07K16/32 , C07K2317/24 , C07K2317/55 , C07K2317/73 , C07K2317/76 , Y10S424/80 , Y10S424/801 , A61K2300/00
摘要： The present application describes methods for treating cancer with anti-ErbB2 antibodies, such as humanized anti-ErbB2 antibodies, and chemotherapeutic agents.
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公开(公告)号：US20060073143A1
公开(公告)日：2006-04-06
申请号：US11222587
申请日：2005-09-09
申请人： Camellia Adams , Leonard Presta , Mark Sliwkowski
发明人： Camellia Adams , Leonard Presta , Mark Sliwkowski
IPC分类号： A61K39/395
CPC分类号： A61K31/282 , A61K31/337 , A61K31/525 , A61K31/7072 , A61K33/24 , A61K39/395 , A61K45/06 , A61K47/6809 , A61K2039/505 , C07K16/32 , C07K2317/24 , C07K2317/55 , C07K2317/73 , C07K2317/76 , Y10S424/80 , Y10S424/801 , A61K2300/00
摘要： The present application describes methods for treating cancer with anti-ErbB2 antibodies, such as humanized anti-ErbB2 antibodies, and anti-hormonal compounds, such as anti-estrogens.
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公开(公告)号：US20060034842A1
公开(公告)日：2006-02-16
申请号：US11223361
申请日：2005-09-09
申请人： Camellia Adams , Leonard Presta , Mark Sliwkowski
发明人： Camellia Adams , Leonard Presta , Mark Sliwkowski
IPC分类号： A61K39/395
CPC分类号： A61K31/282 , A61K31/337 , A61K31/525 , A61K31/7072 , A61K33/24 , A61K39/395 , A61K45/06 , A61K47/6809 , A61K2039/505 , C07K16/32 , C07K2317/24 , C07K2317/55 , C07K2317/73 , C07K2317/76 , Y10S424/80 , Y10S424/801 , A61K2300/00
摘要： The present application describes methods for treating ErbB-expressing cancer with anti-ErbB2 antibody combinations.
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公开(公告)号：US20050208043A1
公开(公告)日：2005-09-22
申请号：US11044749
申请日：2005-01-27
申请人： Camellia Adams , Leonard Presta , Mark Sliwkowski
发明人： Camellia Adams , Leonard Presta , Mark Sliwkowski
IPC分类号： A61K47/48 , C07K16/32 , A61K39/395 , C07K16/44
CPC分类号： A61K31/282 , A61K31/337 , A61K31/525 , A61K31/7072 , A61K33/24 , A61K39/395 , A61K45/06 , A61K47/6809 , A61K2039/505 , C07K16/32 , C07K2317/24 , C07K2317/55 , C07K2317/73 , C07K2317/76 , Y10S424/80 , Y10S424/801 , A61K2300/00
摘要： The present application describes humanized anti-ErbB2 antibodies and methods for treating cancer with anti-ErbB2 antibodies, such as humanized anti-ErbB2 antibodies.
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公开(公告)号：US20060216285A1
公开(公告)日：2006-09-28
申请号：US11429363
申请日：2006-05-05
申请人： Camellia Adams , Leonard Presta , Mark Sliwkowski
发明人： Camellia Adams , Leonard Presta , Mark Sliwkowski
IPC分类号： A61K39/395
CPC分类号： A61K31/282 , A61K31/337 , A61K31/525 , A61K31/7072 , A61K33/24 , A61K39/395 , A61K45/06 , A61K47/6809 , A61K2039/505 , C07K16/32 , C07K2317/24 , C07K2317/55 , C07K2317/73 , C07K2317/76 , Y10S424/80 , Y10S424/801 , A61K2300/00
摘要： The present application describes humanized anti-ErbB2 antibodies and methods for treating cancer with anti-ErbB2 antibodies, such as humanized anti-ErbB2 antibodies.
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公开(公告)号：US20060034835A1
公开(公告)日：2006-02-16
申请号：US11147780
申请日：2005-06-07
申请人： Camellia Adams , Andrew Chan , Craig Crowley , Henry Lowman , Gerald Nakamura , Leonard Presta
发明人： Camellia Adams , Andrew Chan , Craig Crowley , Henry Lowman , Gerald Nakamura , Leonard Presta
IPC分类号： A61K39/395 , C07K16/44
CPC分类号： C07K16/2887 , A61K2039/505 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/522 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/75 , C07K2317/92
摘要： The invention provides humanized and chimeric anti-CD20 antibodies for treatment of CD20 positive malignancies and autoimmune diseases.
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公开(公告)号：US20060024300A1
公开(公告)日：2006-02-02
申请号：US11190364
申请日：2005-07-26
申请人： Camellia Adams , Andrew Chan , Craig Crowley , Henry Lowman , Gerald Nakamura , Leonard Presta
发明人： Camellia Adams , Andrew Chan , Craig Crowley , Henry Lowman , Gerald Nakamura , Leonard Presta
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2887 , A61K2039/505 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/522 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/75 , C07K2317/92
摘要： The invention provides humanized and chimeric anti-CD20 antibodies for treatment of CD20 positive malignancies and autoimmune diseases.
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公开(公告)号：US20050276802A1
公开(公告)日：2005-12-15
申请号：US11096046
申请日：2005-03-31
申请人： Camellia Adams , Napoleone Ferrara , Ellen Filvaroff , Weiguang Mao , Leonard Presta , Max Tejada
发明人： Camellia Adams , Napoleone Ferrara , Ellen Filvaroff , Weiguang Mao , Leonard Presta , Max Tejada
IPC分类号： A61K39/395 , C07H21/04 , C07K16/22 , C07K16/28 , C12N5/06
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/73 , C07K2317/76 , Y10S435/81
摘要： Humanized anti-TGF-beta antibodies are provided, as well as methods for their preparation and use, including methods for treating TGF-beta disorders, for example, cancer. Also provided are articles of manufacture designed for various uses that contain the humanized antibodies.
摘要翻译： 提供人源化抗TGF-β抗体，以及其制备和使用方法，包括治疗TGF-β病症例如癌症的方法。 还提供了针对包含人源化抗体的各种用途设计的制品。
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公开(公告)号：US20110293632A1
公开(公告)日：2011-12-01
申请号：US11947982
申请日：2007-11-30
申请人： Leonard Presta
发明人： Leonard Presta
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/28 , C07K16/2839 , C07K16/2887 , C07K16/4291 , C07K2317/14 , C07K2317/21 , C07K2317/52 , C07K2317/524 , C07K2317/71 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C07K2319/00 , C07K2319/30 , C12N2799/022
摘要： The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function as a consequence of one or more amino acid modifications in the Fc region thereof.
摘要翻译： 本发明涉及包含变体Fc区的多肽。 更具体地，本发明涉及由于Fc区中一个或多个氨基酸修饰而具有改变的效应子功能的含Fc区的多肽。
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