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1.发明申请公开(公告)号：US20060193854A1
公开(公告)日：2006-08-31
申请号：US11429361
申请日：2006-05-05
申请人： Camellia Adams , Leonard Presta , Mark Sliwkowski
发明人： Camellia Adams , Leonard Presta , Mark Sliwkowski
IPC分类号： A61K39/395 , A61K31/525 , A61K31/7072 , A61K31/282 , A61K31/337 , A61K33/24
CPC分类号： A61K31/282 , A61K31/337 , A61K31/525 , A61K31/7072 , A61K33/24 , A61K39/395 , A61K45/06 , A61K47/6809 , A61K2039/505 , C07K16/32 , C07K2317/24 , C07K2317/55 , C07K2317/73 , C07K2317/76 , Y10S424/80 , Y10S424/801 , A61K2300/00
摘要： The present application describes humanized anti-ErbB2 antibodies and methods for treating cancer with anti-ErbB2 antibodies, such as humanized anti-ErbB2 antibodies.
摘要翻译： 本申请描述了人源化抗ErbB2抗体和用抗ErbB2抗体如人源化抗ErbB2抗体治疗癌症的方法。
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公开(公告)号：US20050208043A1
公开(公告)日：2005-09-22
申请号：US11044749
申请日：2005-01-27
申请人： Camellia Adams , Leonard Presta , Mark Sliwkowski
发明人： Camellia Adams , Leonard Presta , Mark Sliwkowski
IPC分类号： A61K47/48 , C07K16/32 , A61K39/395 , C07K16/44
CPC分类号： A61K31/282 , A61K31/337 , A61K31/525 , A61K31/7072 , A61K33/24 , A61K39/395 , A61K45/06 , A61K47/6809 , A61K2039/505 , C07K16/32 , C07K2317/24 , C07K2317/55 , C07K2317/73 , C07K2317/76 , Y10S424/80 , Y10S424/801 , A61K2300/00
摘要： The present application describes humanized anti-ErbB2 antibodies and methods for treating cancer with anti-ErbB2 antibodies, such as humanized anti-ErbB2 antibodies.
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公开(公告)号：US20060198843A1
公开(公告)日：2006-09-07
申请号：US11429043
申请日：2006-05-05
申请人： Camellia Adams , Leonard Presta , Mark Sliwkowski
发明人： Camellia Adams , Leonard Presta , Mark Sliwkowski
IPC分类号： A61K39/395 , A61K31/7072 , A61K31/337 , A61K31/282 , A61K33/24
CPC分类号： A61K31/282 , A61K31/337 , A61K31/525 , A61K31/7072 , A61K33/24 , A61K39/395 , A61K45/06 , A61K47/6809 , A61K2039/505 , C07K16/32 , C07K2317/24 , C07K2317/55 , C07K2317/73 , C07K2317/76 , Y10S424/80 , Y10S424/801 , A61K2300/00
摘要： The present application describes methods for treating cancer with anti-ErbB2 antibodies, such as humanized anti-ErbB2 antibodies, and chemotherapeutic agents.
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公开(公告)号：US20060073143A1
公开(公告)日：2006-04-06
申请号：US11222587
申请日：2005-09-09
申请人： Camellia Adams , Leonard Presta , Mark Sliwkowski
发明人： Camellia Adams , Leonard Presta , Mark Sliwkowski
IPC分类号： A61K39/395
CPC分类号： A61K31/282 , A61K31/337 , A61K31/525 , A61K31/7072 , A61K33/24 , A61K39/395 , A61K45/06 , A61K47/6809 , A61K2039/505 , C07K16/32 , C07K2317/24 , C07K2317/55 , C07K2317/73 , C07K2317/76 , Y10S424/80 , Y10S424/801 , A61K2300/00
摘要： The present application describes methods for treating cancer with anti-ErbB2 antibodies, such as humanized anti-ErbB2 antibodies, and anti-hormonal compounds, such as anti-estrogens.
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公开(公告)号：US20060034842A1
公开(公告)日：2006-02-16
申请号：US11223361
申请日：2005-09-09
申请人： Camellia Adams , Leonard Presta , Mark Sliwkowski
发明人： Camellia Adams , Leonard Presta , Mark Sliwkowski
IPC分类号： A61K39/395
CPC分类号： A61K31/282 , A61K31/337 , A61K31/525 , A61K31/7072 , A61K33/24 , A61K39/395 , A61K45/06 , A61K47/6809 , A61K2039/505 , C07K16/32 , C07K2317/24 , C07K2317/55 , C07K2317/73 , C07K2317/76 , Y10S424/80 , Y10S424/801 , A61K2300/00
摘要： The present application describes methods for treating ErbB-expressing cancer with anti-ErbB2 antibody combinations.
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公开(公告)号：US20060216285A1
公开(公告)日：2006-09-28
申请号：US11429363
申请日：2006-05-05
申请人： Camellia Adams , Leonard Presta , Mark Sliwkowski
发明人： Camellia Adams , Leonard Presta , Mark Sliwkowski
IPC分类号： A61K39/395
CPC分类号： A61K31/282 , A61K31/337 , A61K31/525 , A61K31/7072 , A61K33/24 , A61K39/395 , A61K45/06 , A61K47/6809 , A61K2039/505 , C07K16/32 , C07K2317/24 , C07K2317/55 , C07K2317/73 , C07K2317/76 , Y10S424/80 , Y10S424/801 , A61K2300/00
摘要： The present application describes humanized anti-ErbB2 antibodies and methods for treating cancer with anti-ErbB2 antibodies, such as humanized anti-ErbB2 antibodies.
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公开(公告)号：US20120014969A1
公开(公告)日：2012-01-19
申请号：US13181115
申请日：2011-07-12
申请人： Robert Akita , Mark Sliwkowski
发明人： Robert Akita , Mark Sliwkowski
IPC分类号： A61K39/395 , C07K16/46 , C12N5/16 , G01N33/573 , A61P25/00 , C12N1/21 , C12N1/15 , C12N5/10 , A61P35/00 , A61P29/00 , C07K16/40 , C12N1/19
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/32 , C07K2317/55 , C07K2317/76 , G01N33/74 , G01N2333/71
摘要： Antibodies are disclosed which bind to ErbB3 protein and further possess any one or more of the following properties: an ability to reduce heregulin-induced formation of an ErbB2-ErbB3 protein complex in a cell which expresses ErbB2 and ErbB3; the ability to increase the binding affinity of heregulin for ErbB3 protein; and the characteristic of reducing heregulin-induced ErbB2 activation in a cell which expresses ErbB2 and ErbB3.
摘要翻译： 公开了结合ErbB3蛋白并且还具有以下特性中的一种或多种的抗体：在表达ErbB2和ErbB3的细胞中减少asgulin诱导的ErbB2-ErbB3蛋白复合物形成的能力; 增加蛋白对ErbB3蛋白结合亲和力的能力; 以及在表达ErbB2和ErbB3的细胞中减少鸟嘌呤诱导的ErbB2激活的特征。
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公开(公告)号：US20110293614A1
公开(公告)日：2011-12-01
申请号：US13130789
申请日：2009-11-24
申请人： Klaus Elenius , Maija Hollmen , Mark Sliwkowski
发明人： Klaus Elenius , Maija Hollmen , Mark Sliwkowski
IPC分类号： A61K39/395 , A61P35/00 , G01N33/566 , C07K16/40 , C12N5/09
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/32 , C07K2317/30 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/57492 , G01N2333/71
摘要： Compositions and methods useful for detecting and treating cancers which express the HER4 JM-a isoform are disclosed.
摘要翻译： 公开了用于检测和治疗表达HER4 JM-a同种型的癌症的组合物和方法。
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9.发明授权公开(公告)号：US07862817B2
公开(公告)日：2011-01-04
申请号：US11044749
申请日：2005-01-27
IPC分类号： A61K39/395 , C07K16/28 , C12P21/08 , C07K14/705
CPC分类号： A61K31/282 , A61K31/337 , A61K31/525 , A61K31/7072 , A61K33/24 , A61K39/395 , A61K45/06 , A61K47/6809 , A61K2039/505 , C07K16/32 , C07K2317/24 , C07K2317/55 , C07K2317/73 , C07K2317/76 , Y10S424/80 , Y10S424/801 , A61K2300/00
摘要： The present application describes humanized anti-ErbB2 antibodies and methods for treating cancer with anti-ErbB2 antibodies, such as humanized anti-ErbB2 antibodies.
摘要翻译： 本申请描述了人源化抗ErbB2抗体和用抗ErbB2抗体如人源化抗ErbB2抗体治疗癌症的方法。
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10.发明申请公开(公告)号：US20100136033A1
公开(公告)日：2010-06-03
申请号：US12609737
申请日：2009-10-30
IPC分类号： A61K39/395 , C07K16/00 , A61P35/00
CPC分类号： C07K16/3015 , A01K67/0271 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/052 , A01K2227/105 , A01K2267/0331 , A61K9/0019 , A61K39/39558 , A61K47/6803 , A61K47/6855 , A61K47/6871 , A61K2039/505 , C07K16/2863 , C07K16/32 , C07K2317/24 , C12N15/8509
摘要： The application concerns methods of treatment using anti-ErbB receptor antibody-maytansinoid conjugates, and articles of manufacture suitable for use in such methods. In particular, the invention concerns ErbB receptor-directed cancer therapies, using anti-ErbB receptor antibody-maytansinoid conjugates.
摘要翻译： 该应用涉及使用抗ErbB受体抗体 - 美登木素生物碱结合物的治疗方法以及适用于这种方法的制品。 特别地，本发明涉及使用抗ErbB受体抗体 - 美登木素生物碱结合物的ErbB受体指导的癌症治疗。
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