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    THERAPEUTIC AGENT FOR CANCER
    1.
    发明申请
    THERAPEUTIC AGENT FOR CANCER 有权

    公开(公告)号：US20220241315A1

    公开(公告)日：2022-08-04

    申请号：US17596137

    申请日：2020-05-29

    Applicant: CancerStem Tech Inc. ,  OSAKA UNIVERSITY

    Inventor： Hirofumi Yamamoto ,  Xin Wu

    IPC: A61K31/713 ,  A61P35/00

    Abstract: An object of the present invention is to provide a nucleic acid medicine for cancer treatment that makes it possible to treat cancer effectively. miR-4711-5p can suppress the expression of KLF5, TFDP1, and MDM2, as a result suppressing the proliferation, infiltration, and migration of cancer cells effectively, inducing apoptosis and G1 arrest, and also lowering stemness.

    CANCER STEM CELL GROWTH INHIBITOR USING miRNA
    2.
    发明申请
    CANCER STEM CELL GROWTH INHIBITOR USING miRNA 有权

    公开(公告)号：US20210052627A1

    公开(公告)日：2021-02-25

    申请号：US16498986

    申请日：2018-03-30

    Applicant: CancerStem Tech Inc.

    Inventor： Xin Wu ,  Masaki Mori ,  Hirofumi Yamamoto

    IPC: A61K31/7105 ,  A61P35/00 ,  C12N15/113

    Abstract: The purpose of the present invention is to provide a nucleic acid medication for cancer treatment, the medication being capable of suppressing the growth of cancer stem cells and thus effectively treating cancer. hsa-miR-136-5p, hsa-miR-3065-3p, hsa-miR-4727-5p, hsa-miR-378g, hsa-miR-181a-5p, hsa-miR-362-5p, and hsa-miR-608 have remarkably excellent growth inhibitory action on cancer stem cells and are thus useful as a nucleic acid medication for the treatment of various cancers.

    CANCER STEM CELL
    4.
    发明申请
    CANCER STEM CELL 审中-公开

    公开(公告)号：US20200040307A1

    公开(公告)日：2020-02-06

    申请号：US16499094

    申请日：2018-03-30

    Applicant: CancerStem Tech Inc.

    Inventor： Xin Wu ,  Masaki Mori ,  Hirofumi Yamamoto

    IPC: C12N5/095 ,  C12N15/86 ,  G01N33/15 ,  G01N33/50

    Abstract: The purpose of the present invention is to provide: a cancer stem cell having an excellent ability to form tumor tissue; and a method for establishing the cancer stem cell. Cells having a low metabolic function of 26S proteasome are isolated and concentrated from a cancer stem cell group containing cancer stem cells, thereby obtaining cancer stem cells which can form tumor tissue in a living body even when the number of cells is 200 or less.

    Image analysis method, image analysis device, image analysis system, and storage medium
    5.
    发明授权
    Image analysis method, image analysis device, image analysis system, and storage medium 有权

    公开(公告)号：US11321841B2

    公开(公告)日：2022-05-03

    申请号：US16766333

    申请日：2018-11-05

    Applicant: OSAKA UNIVERSITY

    Inventor： Kazuaki Nakane ,  Hirofumi Yamamoto ,  Mizuho Nishio

    IPC: G06T7/00 ,  G06T7/187 ,  G06T7/136 ,  G06T7/11 ,  A61B5/00 ,  A61B6/03

    Abstract: In order to assess, with high accuracy, a degree of a change having occurred in a structure, the present invention includes: a Betti number calculating section (42) configured to (I) generate, with respect to a single captured image obtained by capturing an image of a structure, a plurality of binarized images having respective binarization reference values different from each other and (II) calculate, for each of the plurality of binarized images, a first characteristic numerical value indicative of the number of connected regions each of which is obtained by connecting pixels each having one of pixel values obtained by binarization; and a prediction score determining section (44) configured to determine, in accordance with a result of a comparison, information on a change having occurred in the structure, the comparison having been made between (i) a pattern indicative of a relationship between (a) the respective binarization reference values and (b) the first characteristic numerical value and (ii) a predetermined reference pattern.

    Image analysis method, storage medium, image analysis device, and image analysis system
    7.
    发明授权
    Image analysis method, storage medium, image analysis device, and image analysis system 有权

    公开(公告)号：US12039722B2

    公开(公告)日：2024-07-16

    申请号：US17442499

    申请日：2020-02-12

    Applicant: OSAKA UNIVERSITY

    Inventor： Kazuaki Nakane ,  Hirofumi Yamamoto ,  Sachiko Nankumo ,  Yasuyoshi Tsutsumi

    IPC: G06T7/00 ,  G16H30/40 ,  G16H50/80

    CPC classification number: G06T7/0012 ,  G16H30/40 ,  G16H50/80 ,  G06T2207/30024 ,  G06T2207/30096

    Abstract: By analyzing an image of a cell sample, whether a cell shown in the image is cancerous or not, the type of cancer, etc. are objectively and appropriately determined. An image analyzing device (1) includes: a binarizing section (41) which carries out a binarizing process a plurality of times with respect to a single captured image so as to generate a plurality of binarized images, the binarizing section carrying out the binarizing process each time the binarizing section varies a binarization reference value; a Betti number calculating section (42) which calculates a region number, which indicates the number of hole-shaped regions, with respect to each of the plurality of binarized images which have been generated; and a cancer determining section (43) which determines a type of cancer occurring in a cell included in tissue, on the basis of the binarization reference value which has been applied at a time of generation of one of the plurality of binarized images with respect to which one the region number has a given value.

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